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Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.
Dar HH, Mikulska-Ruminska K, Tyurina YY, Luci DK, Yasgar A, Samovich SN, Kapralov AA, Souryavong AB, Tyurin VA, Amoscato AA, Epperly MW, Shurin GV, Standley M, Holman TR, St Croix CM, Watkins SC, VanDemark AP, Rana S, Zakharov AV, Simeonov A, Marugan J, Mallampalli RK, Wenzel SE, Greenberger JS, Rai G, Bayir H, Bahar I, Kagan VE. Dar HH, et al. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2218896120. doi: 10.1073/pnas.2218896120. Epub 2023 Jun 16. Proc Natl Acad Sci U S A. 2023. PMID: 37327313 Free PMC article.
Proteolytic cleavage and PKA phosphorylation of alpha(1C) subunit are not required for adrenergic regulation of Ca(V)1.2 in the heart.
Katchman A, Yang L, Zakharov SI, Kushner J, Abrams J, Chen BX, Liu G, Pitt GS, Colecraft HM, Marx SO. Katchman A, et al. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9194-9199. doi: 10.1073/pnas.1706054114. Epub 2017 Aug 7. Proc Natl Acad Sci U S A. 2017. PMID: 28784807 Free PMC article.
Calcium influx through the voltage-dependent L-type calcium channel (Ca(V)1.2) rapidly increases in the heart during "fight or flight" through activation of the beta-adrenergic and protein kinase A (PKA) signaling pathway. ...Further, proteolytic cleavage of alpha(1C) is n …
Calcium influx through the voltage-dependent L-type calcium channel (Ca(V)1.2) rapidly increases in the heart during "fight or flight …
Differences in spatial versus temporal reaction norms for spring and autumn phenological events.
Delgado MDM, Roslin T, Tikhonov G, Meyke E, Lo C, Gurarie E, Abadonova M, Abduraimov O, Adrianova O, Akimova T, Akkiev M, Ananin A, Andreeva E, Andriychuk N, Antipin M, Arzamascev K, Babina S, Babushkin M, Bakin O, Barabancova A, Basilskaja I, Belova N, Belyaeva N, Bespalova T, Bisikalova E, Bobretsov A, Bobrov V, Bobrovskyi V, Bochkareva E, Bogdanov G, Bolshakov V, Bondarchuk S, Bukharova E, Butunina A, Buyvolov Y, Buyvolova A, Bykov Y, Chakhireva E, Chashchina O, Cherenkova N, Chistjakov S, Chuhontseva S, Davydov EA, Demchenko V, Diadicheva E, Dobrolyubov A, Dostoyevskaya L, Drovnina S, Drozdova Z, Dubanaev A, Dubrovsky Y, Elsukov S, Epova L, Ermakova OS, Ermakova O, Esengeldenova A, Evstigneev O, Fedchenko I, Fedotova V, Filatova T, Gashev S, Gavrilov A, Gaydysh I, Golovcov D, Goncharova N, Gorbunova E, Gordeeva T, Grishchenko V, Gromyko L, Hohryakov V, Hritankov A, Ignatenko E, Igosheva S, Ivanova U, Ivanova N, Kalinkin Y, Kaygorodova E, Kazansky F, Kiseleva D, Knorre A, Kolpashikov L, Korobov E, Korolyova H, Korotkikh N, Kosenkov G, Kossenko S, Kotlugalyamova E, Kozlovsky E, Kozsheechkin V, Kozurak A, Kozyr I, Krasnopevtseva A, Kruglikov S, Kuberskaya O, Kudryavtsev A, Kuleby… See abstract for full author list ➔ Delgado MDM, et al. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31249-31258. doi: 10.1073/pnas.2002713117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229550 Free PMC article.
Membrane-bound state of the colicin E1 channel domain as an extended two-dimensional helical array.
Zakharov SD, Lindeberg M, Griko Y, Salamon Z, Tollin G, Prendergast FG, Cramer WA. Zakharov SD, et al. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4282-7. doi: 10.1073/pnas.95.8.4282. Proc Natl Acad Sci U S A. 1998. PMID: 9539728 Free PMC article.
The average distance between helical segments is increased and interhelix interactions are weakened, as shown by a major loss of tertiary structure interactions, decreased efficiency of fluorescence resonance energy transfer from an energy donor on helix V of P190 to an ac …
The average distance between helical segments is increased and interhelix interactions are weakened, as shown by a major loss of tertiary st …