Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease.
Dehghan A, Pinto RC, Karaman I, Huang J, Durainayagam BR, Ghanbari M, Nazeer A, Zhong Q, Liggi S, Whiley L, Mustafa R, Kivipelto M, Solomon A, Ngandu T, Kanekiyo T, Aikawa T, Radulescu CI, Barnes SJ, Graça G, Chekmeneva E, Camuzeaux S, Lewis MR, Kaluarachchi MR, Ikram MA, Holmes E, Tzoulaki I, Matthews PM, Griffin JL, Elliott P.
Dehghan A, et al.
Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2206083119. doi: 10.1073/pnas.2206083119. Epub 2022 Oct 21.
Proc Natl Acad Sci U S A. 2022.
PMID: 36269859
Free PMC article.
Genome-wide association studies (GWASs) have identified genetic loci associated with the risk of Alzheimer's disease (AD), but the molecular mechanisms by which they confer risk are largely unknown. ...
Genome-wide association studies (GWASs) have identified genetic loci associated with the risk of Alzheimer's disease (AD), but the mo …