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1956 1
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1999 12
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498 results

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Page 1
A holin/peptidoglycan hydrolase-dependent protein secretion system.
Palmer T, Finney AJ, Saha CK, Atkinson GC, Sargent F. Palmer T, et al. Mol Microbiol. 2021 Mar;115(3):345-355. doi: 10.1111/mmi.14599. Epub 2020 Oct 12. Mol Microbiol. 2021. PMID: 32885520 Free article. Review.
Gram-negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein secretion system that uses a holin membrane protein in tandem with a cell wall-editing enzyme to mediate the secretion of substrate pr …
Gram-negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein s …
A Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL in Paeniclostridiumsordellii.
Vidor CJ, Hamiot A, Wisniewski J, Mathias RA, Dupuy B, Awad M, Lyras D. Vidor CJ, et al. Toxins (Basel). 2022 Feb 8;14(2):124. doi: 10.3390/toxins14020124. Toxins (Basel). 2022. PMID: 35202151 Free PMC article.
Here, we confirm that each of the LCGT-producing clostridia encode functional holin-like proteins in close proximity to the toxin genes. To characterise the respective roles of these holin-like proteins in the release of the LCGTs, P. sordellii and its lethal toxin, …
Here, we confirm that each of the LCGT-producing clostridia encode functional holin-like proteins in close proximity to the toxin gen …
Bactericidal activity of a holin-endolysin system derived from Vibrio alginolyticus phage HH109.
Li X, Zhang C, Wei F, Yu F, Zhao Z. Li X, et al. Microb Pathog. 2021 Oct;159:105135. doi: 10.1016/j.micpath.2021.105135. Epub 2021 Aug 12. Microb Pathog. 2021. PMID: 34390766
Our data revealed that the endolysin of the phage HH109 has stronger bactericidal activity than the holin, as evidenced by observing more cell death and severe structural damage of cells in the endolysin-expressing E. coli. ...Transmission electron microscopy observation r …
Our data revealed that the endolysin of the phage HH109 has stronger bactericidal activity than the holin, as evidenced by observing …
Phage Lysis: Multiple Genes for Multiple Barriers.
Cahill J, Young R. Cahill J, et al. Adv Virus Res. 2019;103:33-70. doi: 10.1016/bs.aivir.2018.09.003. Epub 2018 Nov 28. Adv Virus Res. 2019. PMID: 30635077 Free PMC article. Review.
For Caudovirales of Gram-negative hosts, there are two different systems: the holin-endolysin and pinholin-SAR endolysin pathways. In the former, lysis is initiated when the holin forms micron-scale holes in the inner membrane, releasing active endolysin into the pe …
For Caudovirales of Gram-negative hosts, there are two different systems: the holin-endolysin and pinholin-SAR endolysin pathways. In …
A Cytoplasmic Antiholin Is Embedded In Frame with the Holin in a Lactobacillus fermentum Bacteriophage.
Guo T, Xin Y, Zhang C, Kong J. Guo T, et al. Appl Environ Microbiol. 2018 Mar 1;84(6):e02518-17. doi: 10.1128/AEM.02518-17. Print 2018 Mar 15. Appl Environ Microbiol. 2018. PMID: 29305511 Free PMC article.
In double-stranded DNA bacteriophages, infection cycles are ended by host cell lysis through the action of phage-encoded endolysins and holins. The precise timing of lysis is regulated by the holin inhibitors, named antiholins. ...As a prominent biological group in …
In double-stranded DNA bacteriophages, infection cycles are ended by host cell lysis through the action of phage-encoded endolysins and h
Regulation and Functionality of a Holin/Endolysin Pair Involved in Killing of Galleria mellonella and Caenorhabditis elegans by Yersinia enterocolitica.
Sänger PA, Knüpfer M, Kegel M, Spanier B, Liebler-Tenorio EM, Fuchs TM. Sänger PA, et al. Appl Environ Microbiol. 2023 Jun 28;89(6):e0003623. doi: 10.1128/aem.00036-23. Epub 2023 May 15. Appl Environ Microbiol. 2023. PMID: 37184385 Free PMC article.
In this study, we investigated the regulation and functionality of a phage-related holin/endolysin (HE) cassette located within the insecticidal pathogenicity island Tc-PAI(Ye) of W22703. ...Oral infection of Caenorhabditis elegans with a HE deletion mutant attenuated the …
In this study, we investigated the regulation and functionality of a phage-related holin/endolysin (HE) cassette located within the i …
A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens.
Hamilton JJ, Marlow VL, Owen RA, Costa Mde A, Guo M, Buchanan G, Chandra G, Trost M, Coulthurst SJ, Palmer T, Stanley-Wall NR, Sargent F. Hamilton JJ, et al. J Cell Biol. 2014 Dec 8;207(5):615-26. doi: 10.1083/jcb.201404127. J Cell Biol. 2014. PMID: 25488919 Free PMC article.
In this work, genetic, biochemical, and proteomic approaches identified genes that were required for secretion of all three chitinases and Cbp21. A genetic screen identified a holin-like protein (ChiW) and a putative l-alanyl-d-glutamate endopeptidase (ChiX), and subsequen …
In this work, genetic, biochemical, and proteomic approaches identified genes that were required for secretion of all three chitinases and C …
Holin-assisted bacterial recombinant protein export.
Guo T, Cui Y, Zhang L, Xu X, Xu Z, Kong J. Guo T, et al. Biotechnol Bioeng. 2022 Oct;119(10):2908-2918. doi: 10.1002/bit.28179. Epub 2022 Jul 28. Biotechnol Bioeng. 2022. PMID: 35822237
A simple generic method for enhancing extracellular protein yields in engineered bacteria is still lacking. Here, we demonstrated that phage-encoded holin can be used to export proteins to the extracellular medium in both Gram-negative Escherichia coli and -positive Lactoc …
A simple generic method for enhancing extracellular protein yields in engineered bacteria is still lacking. Here, we demonstrated that phage …
Activity of a Holin-Endolysin System in the Insecticidal Pathogenicity Island of Yersinia enterocolitica.
Springer K, Reuter S, Knüpfer M, Schmauder L, Sänger PA, Felsl A, Fuchs TM. Springer K, et al. J Bacteriol. 2018 Jul 25;200(16):e00180-18. doi: 10.1128/JB.00180-18. Print 2018 Aug 15. J Bacteriol. 2018. PMID: 29866807 Free PMC article.
The island also harbors four phage-related and highly conserved genes of unknown functions, which are polycistronically transcribed. Two open reading frames showed significant homologies to holins and endolysins and exhibited lytic activity in Escherichia coli cells upon o …
The island also harbors four phage-related and highly conserved genes of unknown functions, which are polycistronically transcribed. Two ope …
Identification and Characterization of a New Type of Holin-Endolysin Lysis Cassette in Acidovorax oryzae Phage AP1.
Zhang M, Wang Y, Chen J, Hong X, Xu X, Wu Z, Ahmed T, Loh B, Leptihn S, Hassan S, Hassan MM, Sun G, Li B. Zhang M, et al. Viruses. 2022 Jan 18;14(2):167. doi: 10.3390/v14020167. Viruses. 2022. PMID: 35215761 Free PMC article.
We performed in silico bioinformatics analyses, which indicated that the lysis cassette contains a holin (HolAP) and endolysin (LysAP), which are encoded by two adjacent genes. ...
We performed in silico bioinformatics analyses, which indicated that the lysis cassette contains a holin (HolAP) and endolysin (LysAP …
498 results