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Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration.
Karunarathne WK, Giri L, Patel AK, Venkatesh KV, Gautam N. Karunarathne WK, et al. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1575-83. doi: 10.1073/pnas.1220755110. Epub 2013 Apr 8. Proc Natl Acad Sci U S A. 2013. PMID: 23569254 Free PMC article.
There is a dearth of approaches to experimentally direct cell migration by continuously varying signal input to a single cell, evoking all possible migratory responses and quantitatively monitoring the cellular and molecular response dynamics. Here we used a visual blue opsin to …
There is a dearth of approaches to experimentally direct cell migration by continuously varying signal input to a single cell, evoking all p …
Variation in sequence and organization of splicing regulatory elements in vertebrate genes.
Yeo G, Hoon S, Venkatesh B, Burge CB. Yeo G, et al. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15700-5. doi: 10.1073/pnas.0404901101. Epub 2004 Oct 25. Proc Natl Acad Sci U S A. 2004. PMID: 15505203 Free PMC article.
However, another class of splicing regulatory elements, the intronic splicing enhancers, appears to differ substantially between mammals and fish, with G triples (GGG) very abundant in mammalian introns but comparatively rare in fish. ...
However, another class of splicing regulatory elements, the intronic splicing enhancers, appears to differ substantially between mammals and …