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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1970 1
1972 1
1973 3
1974 7
1975 6
1976 2
1977 6
1978 7
1979 9
1980 4
1981 4
1982 2
1983 6
1984 12
1985 14
1986 7
1987 7
1988 8
1989 10
1990 2
1991 8
1992 14
1993 7
1994 10
1995 4
1996 6
1997 10
1998 7
1999 8
2000 12
2001 14
2002 12
2003 8
2004 6
2005 18
2006 34
2007 30
2008 28
2009 25
2010 33
2011 23
2012 28
2013 21
2014 61
2015 56
2016 96
2017 69
2018 56
2019 69
2020 65
2021 61
2022 54
2023 50
2024 25

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1,021 results

Results by year

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Page 1
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Schubart A, Anderson K, Mainolfi N, Sellner H, Ehara T, Adams CM, Mac Sweeney A, Liao SM, Crowley M, Littlewood-Evans A, Sarret S, Wieczorek G, Perrot L, Dubost V, Flandre T, Zhang Y, Smith RJH, Risitano AM, Karki RG, Zhang C, Valeur E, Sirockin F, Gerhartz B, Erbel P, Hughes N, Smith TM, Cumin F, Argikar UA, Haraldsson B, Mogi M, Sedrani R, Wiesmann C, Jaffee B, Maibaum J, Flohr S, Harrison R, Eder J. Schubart A, et al. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931. doi: 10.1073/pnas.1820892116. Epub 2019 Mar 29. Proc Natl Acad Sci U S A. 2019. PMID: 30926668 Free PMC article.
Here we describe the discovery of a highly potent, reversible, and selective small-molecule inhibitor of factor B, a serine protease that drives the central amplification loop of the AP. ...These data demonstrate the potential therapeutic value of using a factor B i …
Here we describe the discovery of a highly potent, reversible, and selective small-molecule inhibitor of factor B, a serine protease …
Drugging an undruggable pocket on KRAS.
Kessler D, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, Mayer M, Gollner A, Covini D, Fischer S, Gerstberger T, Gmaschitz T, Goodwin C, Greb P, Häring D, Hela W, Hoffmann J, Karolyi-Oezguer J, Knesl P, Kornigg S, Koegl M, Kousek R, Lamarre L, Moser F, Munico-Martinez S, Peinsipp C, Phan J, Rinnenthal J, Sai J, Salamon C, Scherbantin Y, Schipany K, Schnitzer R, Schrenk A, Sharps B, Siszler G, Sun Q, Waterson A, Wolkerstorfer B, Zeeb M, Pearson M, Fesik SW, McConnell DB. Kessler D, et al. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15823-15829. doi: 10.1073/pnas.1904529116. Epub 2019 Jul 22. Proc Natl Acad Sci U S A. 2019. PMID: 31332011 Free PMC article.
A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis.
Ramesh A, Schubert RD, Greenfield AL, Dandekar R, Loudermilk R, Sabatino JJ Jr, Koelzer MT, Tran EB, Koshal K, Kim K, Pröbstel AK, Banerji D; University of California, San Francisco MS-EPIC Team; Guo CY, Green AJ, Bove RM, DeRisi JL, Gelfand JM, Cree BAC, Zamvil SS, Baranzini SE, Hauser SL, Wilson MR. Ramesh A, et al. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22932-22943. doi: 10.1073/pnas.2008523117. Epub 2020 Aug 28. Proc Natl Acad Sci U S A. 2020. PMID: 32859762 Free PMC article.
Independent analyses across technologies demonstrated that nuclear factor kappa B (NF-kappaB) and cholesterol biosynthesis pathways were activated, and specific cytokine and chemokine receptors were up-regulated in CSF memory B cells. ...Clonally expanded, somatical …
Independent analyses across technologies demonstrated that nuclear factor kappa B (NF-kappaB) and cholesterol biosynthesis pathways w …
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, Werbeck ND, Briem H, Boemer U, Weiske J, Badock V, Mastouri J, Petersen K, Siemeister G, Kahmann JD, Wegener D, Böhnke N, Eis K, Graham K, Wortmann L, von Nussbaum F, Bader B. Hillig RC, et al. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25. Proc Natl Acad Sci U S A. 2019. PMID: 30683722 Free PMC article.
Outcomes of gynecologic cancer surgery during the COVID-19 pandemic: an international, multicenter, prospective CovidSurg-Gynecologic Oncology Cancer study.
Fotopoulou C, Khan T, Bracinik J, Glasbey J, Abu-Rustum N, Chiva L, Fagotti A, Fujiwara K, Ghebre R, Gutelkin M, Konney TO, Ng J, Pareja R, Kottayasamy Seenivasagam R, Sehouli J, Surappa STS, Bhangu A, Leung E, Sundar S; CovidSurg Gynecological Cancer Collaborators. Fotopoulou C, et al. Am J Obstet Gynecol. 2022 Nov;227(5):735.e1-735.e25. doi: 10.1016/j.ajog.2022.06.052. Epub 2022 Jun 30. Am J Obstet Gynecol. 2022. PMID: 35779589 Free PMC article.
X(3)sigma(g)(-) b(1)sigma(g)(+) Absorption Spectra of Molecular Oxygen in Liquid Organic Solvents at Atmospheric Pressure.
Bregnhøj M, McLoughlin CK, Breitenbach T, Ogilby PR. Bregnhøj M, et al. J Phys Chem A. 2022 Jun 16;126(23):3839-3845. doi: 10.1021/acs.jpca.2c03053. Epub 2022 Jun 1. J Phys Chem A. 2022. PMID: 35649157
Spectra and absorption coefficients of the forbidden 765 nm X(3)sigma(g)(-) b(1)sigma(g)(+) transition of molecular oxygen dissolved in organic solvents at atmospheric pressure were recorded over a 5 m path length using a liquid waveguide capillary cel …
Spectra and absorption coefficients of the forbidden 765 nm X(3)sigma(g)(-) b(1)sigma(g)(+) transition of molecular oxy …
Raman spectroscopy studies of black phosphorus.
Liu Y, Zou J, Chen S, Zhong B, Wang Y, Wang H, Huang X. Liu Y, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2022 Apr 15;271:120861. doi: 10.1016/j.saa.2022.120861. Epub 2022 Jan 7. Spectrochim Acta A Mol Biomol Spectrosc. 2022. PMID: 35051798
We successfully distinguished the armchair and zigzag directions of black phosphorus by angle-resolved polarized Raman spectroscopy of A(g) mode in a less studied orthogonal polarization configuration. ...It is found that the first order temperature coefficients of its thr …
We successfully distinguished the armchair and zigzag directions of black phosphorus by angle-resolved polarized Raman spectroscopy of A( …
Is perioperative COVID-19 really associated with worse surgical outcomes? A nationwide COVIDSurg propensity-matched analysis.
Argandykov D, Dorken-Gallastegi A, El Moheb M, Gebran A, Proaño-Zamudio JA, Bokenkamp M, Renne AM, Nepogodiev D, Bhangu A, Kaafarani HMA; COVIDSurg Collaborative. Argandykov D, et al. J Trauma Acute Care Surg. 2023 Apr 1;94(4):513-524. doi: 10.1097/TA.0000000000003859. Epub 2023 Jan 19. J Trauma Acute Care Surg. 2023. PMID: 36949053 Free PMC article.
METHODS: Patients with perioperative COVID-19 diagnosed within 7 days before or 30 days after surgery between February and July 2020 from 68 US hospitals in COVIDSurg, an international multicenter database, were 1:1 propensity score matched to patients without COVID-19 undergoing …
METHODS: Patients with perioperative COVID-19 diagnosed within 7 days before or 30 days after surgery between February and July 2020 from 68 …
Seeing unique hues.
Abramov I, Gordon J. Abramov I, et al. J Opt Soc Am A Opt Image Sci Vis. 2005 Oct;22(10):2143-53. doi: 10.1364/josaa.22.002143. J Opt Soc Am A Opt Image Sci Vis. 2005. PMID: 16277284 Clinical Trial.
Hue can be described by four separate sensations of red (R), green (G), yellow (Y), and blue (B). These are combined in the spectrally opponent RG and YB mechanisms, whose null points correspond to the unique sensations of Y, G, B. ...The shifts in uni …
Hue can be described by four separate sensations of red (R), green (G), yellow (Y), and blue (B). These are combined in the sp …
Charge transport in DNA in solution: the role of polarons.
Conwell EM. Conwell EM. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8795-9. doi: 10.1073/pnas.0501406102. Epub 2005 Jun 14. Proc Natl Acad Sci U S A. 2005. PMID: 15956188 Free PMC article. Review.
Particularly influential experiments were carried out by Giese [Giese, B. (2000) Acc. Chem. Res. 33, 631-636] on the sequence G(A)(n)GGG, where G is guanine and A is adenine. ...Transport by these polarons could explain the results of Giese et al. [Giese, …
Particularly influential experiments were carried out by Giese [Giese, B. (2000) Acc. Chem. Res. 33, 631-636] on the sequence G …
1,021 results