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Type I interferon is a therapeutic target for virus-induced lethal vascular damage.
Baccala R, Welch MJ, Gonzalez-Quintial R, Walsh KB, Teijaro JR, Nguyen A, Ng CT, Sullivan BM, Zarpellon A, Ruggeri ZM, de la Torre JC, Theofilopoulos AN, Oldstone MB. Baccala R, et al. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8925-30. doi: 10.1073/pnas.1408148111. Epub 2014 Jun 2. Proc Natl Acad Sci U S A. 2014. PMID: 24889626 Free PMC article.
The clone 13 (Cl13) variant of lymphocytic choriomeningitis virus--a prototype of Old World arenaviruses closely related to Lassa fever virus--elicits in C57BL/6 and BALB/c mice abundant negative immunoregulatory molecules, associated with T-cell exhaustion, negligible T-c …
The clone 13 (Cl13) variant of lymphocytic choriomeningitis virus--a prototype of Old World arenaviruses closely related to Lassa fever viru …
Family matters: Variation in the physiology of brooded Porites astreoides larvae is driven by parent colony effects.
Zhang Y, Million WC, Ruggeri M, Kenkel CD. Zhang Y, et al. Comp Biochem Physiol A Mol Integr Physiol. 2019 Dec;238:110562. doi: 10.1016/j.cbpa.2019.110562. Epub 2019 Sep 4. Comp Biochem Physiol A Mol Integr Physiol. 2019. PMID: 31493555
Family accounted for more variation than day of release and reef origin, with >60% of the variation in chlorophyll a and protein content explained by family. The survivorship of larvae under 36 C acute temperature stress was also tightly linked to what parent colony the …
Family accounted for more variation than day of release and reef origin, with >60% of the variation in chlorophyll a and protein content …
Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system.
Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R. Kallupi M, et al. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19567-72. doi: 10.1073/pnas.1004100107. Epub 2010 Oct 25. Proc Natl Acad Sci U S A. 2010. PMID: 20974945 Free PMC article.
Manipulation of the NPS receptor system did not modify cocaine self-administration. We also found that ICV NPS administration activates c-Fos expression in hypocretin-1/orexin-A (Hcrt-1/Ox-A) immunoreactive neurons in the lateral hypothalamus (LH) and in the perifornical a …
Manipulation of the NPS receptor system did not modify cocaine self-administration. We also found that ICV NPS administration activates c
Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding.
Cattaneo M, Zighetti ML, Lombardi R, Martinez C, Lecchi A, Conley PB, Ware J, Ruggeri ZM. Cattaneo M, et al. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1978-83. doi: 10.1073/pnas.0437879100. Epub 2003 Feb 10. Proc Natl Acad Sci U S A. 2003. PMID: 12578987 Free PMC article.
Analysis of the patient's P2Y(12) gene revealed a G-to-A transition in one allele, changing the codon for Arg-256 in the sixth transmembrane domain to Gln, and a C-to-T transition in the other allele, changing the codon for Arg-265 in the third extracellular loop to Trp. . …
Analysis of the patient's P2Y(12) gene revealed a G-to-A transition in one allele, changing the codon for Arg-256 in the sixth transmembrane …
Defective dimerization of von Willebrand factor subunits due to a Cys-> Arg mutation in type IID von Willebrand disease.
Schneppenheim R, Brassard J, Krey S, Budde U, Kunicki TJ, Holmberg L, Ware J, Ruggeri ZM. Schneppenheim R, et al. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3581-6. doi: 10.1073/pnas.93.8.3581. Proc Natl Acad Sci U S A. 1996. PMID: 8622978 Free PMC article.
The same heterozygous T -> C transition at nt 8567 of the von Willebrand factor (vWF) transcript was found in two unrelated patients with type III) von Willebrand disease, with no other apparent abnormality. ...
The same heterozygous T -> C transition at nt 8567 of the von Willebrand factor (vWF) transcript was found in two unrelated patien …