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Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis.
Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. Birrane G, et al. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1723-1732. doi: 10.1073/pnas.1817984116. Epub 2018 Dec 17. Proc Natl Acad Sci U S A. 2019. PMID: 30559189 Free PMC article.
Inspired by our recent discovery that GPIHBP1's acidic domain preserves LPL structure and activity, we crystallized an LPL-GPIHBP1 complex and solved its structure. GPIHBP1's LU domain binds to LPL's C-terminal domain, largely by hydrophobic interactions. Analysis of elect …
Inspired by our recent discovery that GPIHBP1's acidic domain preserves LPL structure and activity, we crystallized an LPL-GPIHBP1 complex a …
The W148L substitution in the Escherichia coli ammonium channel AmtB increases flux and indicates that the substrate is an ion.
Fong RN, Kim KS, Yoshihara C, Inwood WB, Kustu S. Fong RN, et al. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18706-11. doi: 10.1073/pnas.0709267104. Epub 2007 Nov 12. Proc Natl Acad Sci U S A. 2007. PMID: 17998534 Free PMC article.
A strain carrying AmtB(W148L) accumulates much larger amounts of both [(14)C]methylammonium and [(14)C]methylglutamine in a washed cell assay than a strain carrying wild-type AmtB. ...Concentration of methylammonium was most easily studied in strains that lack gluta …
A strain carrying AmtB(W148L) accumulates much larger amounts of both [(14)C]methylammonium and [(14)C]methylglutamine in a wa …
Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression.
DeLisser H, Liu Y, Desprez PY, Thor A, Briasouli P, Handumrongkul C, Wilfong J, Yount G, Nosrati M, Fong S, Shtivelman E, Fehrenbach M, Cao G, Moore DH, Nayak S, Liggitt D, Kashani-Sabet M, Debs R. DeLisser H, et al. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18616-21. doi: 10.1073/pnas.1004654107. Epub 2010 Oct 6. Proc Natl Acad Sci U S A. 2010. PMID: 20926749 Free PMC article.
cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium.
Haskill S, Martin G, Van Le L, Morris J, Peace A, Bigler CF, Jaffe GJ, Hammerberg C, Sporn SA, Fong S, et al. Haskill S, et al. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3681-5. doi: 10.1073/pnas.88.9.3681. Proc Natl Acad Sci U S A. 1991. PMID: 1827201 Free PMC article.
A cDNA encoding a receptor antagonist of interleukin 1 (IL-1ra), secreted from human monocytes, has recently been isolated and sequenced [Eisenberg, S. P., Evans, R. J., Arend, W. P., Verderber, E., Brewer, M. T., Hannum, C. H. & Thompson, R. C. (1990) Na …
A cDNA encoding a receptor antagonist of interleukin 1 (IL-1ra), secreted from human monocytes, has recently been isolated and sequenced [Ei …