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Page 1
Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus.
Caramia M, Romanov RA, Sideromenos S, Hevesi Z, Zhao M, Krasniakova M, Xu ZD, Harkany T, Hökfelt TGM. Caramia M, et al. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2222095120. doi: 10.1073/pnas.2222095120. Epub 2023 Jul 24. Proc Natl Acad Sci U S A. 2023. PMID: 37487094 Free PMC article.
We found that NE neurons expressed at least 19 neuropeptide transcripts, notably galanin (Gal) but not Npy, and >30 neuropeptide receptors. Among the galanin receptors, Galr1 was expressed in ~19% of NE neurons, as was also confirmed by in situ hybridization. ... …
We found that NE neurons expressed at least 19 neuropeptide transcripts, notably galanin (Gal) but not Npy, and >30 neuropeptide r …
A role for galanin in human and experimental inflammatory demyelination.
Wraith DC, Pope R, Butzkueven H, Holder H, Vanderplank P, Lowrey P, Day MJ, Gundlach AL, Kilpatrick TJ, Scolding N, Wynick D. Wraith DC, et al. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15466-71. doi: 10.1073/pnas.0903360106. Epub 2009 Aug 26. Proc Natl Acad Sci U S A. 2009. PMID: 19717462 Free PMC article.
Over-expression of galanin in transgenic mice (Gal-OE) abolishes disease in the EAE model, whilst loss-of-function mutations in galanin or galanin receptor-2 (GalR2) increase disease severity. ...Irrespective of the mechanism(s) by which galanin alters …
Over-expression of galanin in transgenic mice (Gal-OE) abolishes disease in the EAE model, whilst loss-of-function mutations in ga …
Galanin acts as a neuroprotective factor to the hippocampus.
Elliott-Hunt CR, Marsh B, Bacon A, Pope R, Vanderplank P, Wynick D. Elliott-Hunt CR, et al. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5105-10. doi: 10.1073/pnas.0304823101. Epub 2004 Mar 23. Proc Natl Acad Sci U S A. 2004. PMID: 15041741 Free PMC article.
We have recently demonstrated that peripheral sensory neurons depend on galanin for neurite extension after injury, mediated by activation of the second galanin receptor subtype (GALR2). ...These results demonstrate that galanin acts an endogenous neuroprotec …
We have recently demonstrated that peripheral sensory neurons depend on galanin for neurite extension after injury, mediated by activ …
Structural insights into galanin receptor signaling.
Jiang W, Zheng S. Jiang W, et al. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2121465119. doi: 10.1073/pnas.2121465119. Epub 2022 May 20. Proc Natl Acad Sci U S A. 2022. PMID: 35594396 Free PMC article.
Galanin is a biologically active neuropeptide, and functions through three distinct G protein-coupled receptors (GPCRs), namely GALR1, GALR2, and GALR3. ...Here, we report the cryoelectron microscopy structures of the GALR1-Go and the GALR2-Gq complexes bound to the endoge …
Galanin is a biologically active neuropeptide, and functions through three distinct G protein-coupled receptors (GPCRs), namely GALR1 …
Anticonvulsant activity of a nonpeptide galanin receptor agonist.
Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U. Saar K, et al. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7136-41. doi: 10.1073/pnas.102163499. Proc Natl Acad Sci U S A. 2002. PMID: 12011470 Free PMC article.
No nonpeptide ligands, capable of activating galanin receptors, are available today. Based on known pharmacophores of galanin, a combinatorial library was designed, synthesized, and screened at the rat hippocampal galanin receptor. ...These findings introduce …
No nonpeptide ligands, capable of activating galanin receptors, are available today. Based on known pharmacophores of galanin, …
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
Lu X, Barr AM, Kinney JW, Sanna P, Conti B, Behrens MM, Bartfai T. Lu X, et al. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):874-9. doi: 10.1073/pnas.0408891102. Epub 2005 Jan 12. Proc Natl Acad Sci U S A. 2005. PMID: 15647369 Free PMC article.
In the present study, we demonstrated that 14 days of FLX treatment up-regulated galanin mRNA levels by 100% and GalR2-binding sites by 50%, in the rat dorsal raphe nucleus, where galanin coexists with serotonin. ...Direct activation of galanin receptors by a …
In the present study, we demonstrated that 14 days of FLX treatment up-regulated galanin mRNA levels by 100% and GalR2-binding sites …
Synthesis of galmic: a nonpeptide galanin receptor agonist.
Ceide SC, Trembleau L, Haberhauer G, Somogyi L, Lu X, Bartfai T, Rebek J Jr. Ceide SC, et al. Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16727-32. doi: 10.1073/pnas.0407543101. Epub 2004 Nov 19. Proc Natl Acad Sci U S A. 2004. PMID: 15557002 Free PMC article.
Galanin is a neuropeptide with a wide variety of biological functions. Few nonpeptide ligands, capable of activating galanin receptors, are available today. Based on known pharmacophores of galanin and the tripeptidomimetic galnon, a combinatorial library was …
Galanin is a neuropeptide with a wide variety of biological functions. Few nonpeptide ligands, capable of activating galanin r …
Molecular cloning of a functional human galanin receptor.
Habert-Ortoli E, Amiranoff B, Loquet I, Laburthe M, Mayaux JF. Habert-Ortoli E, et al. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9780-3. doi: 10.1073/pnas.91.21.9780. Proc Natl Acad Sci U S A. 1994. PMID: 7524088 Free PMC article.
The cloned receptor expressed in COS cells specifically binds human, porcine, and rat galanin with high affinity (Kd in the nanomolar range) and mediates the galanin inhibition of adenylate cyclase. A 2.8-kb galanin receptor transcript was identified in sever …
The cloned receptor expressed in COS cells specifically binds human, porcine, and rat galanin with high affinity (Kd in the nanomolar …
Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 differentiate it from the brain/gut receptor.
Wynick D, Smith DM, Ghatei M, Akinsanya K, Bhogal R, Purkiss P, Byfield P, Yanaihara N, Bloom SR. Wynick D, et al. Proc Natl Acad Sci U S A. 1993 May 1;90(9):4231-5. doi: 10.1073/pnas.90.9.4231. Proc Natl Acad Sci U S A. 1993. PMID: 7683428 Free PMC article.
M15, a chimeric peptide comprising galanin 1-13 and substance P5-11, has recently been found to be a potent galanin antagonist. ...Addition of M15 produced no effect on basal or galanin-stimulated prolactin release. Galanin fragment 3-29 was fully acti …
M15, a chimeric peptide comprising galanin 1-13 and substance P5-11, has recently been found to be a potent galanin antagonist …
Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors.
Chen Y, Song Y, Wang H, Zhang Y, Hu X, Wang K, Lu Y, Zhang Z, Li S, Li A, Bao L, Xu F, Li C, Zhang X. Chen Y, et al. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2118501119. doi: 10.1073/pnas.2118501119. Epub 2022 Aug 9. Proc Natl Acad Sci U S A. 2022. PMID: 35943985 Free PMC article.
Here, we use the type 1 herpes simplex virus H129 strain to trace the neural networks derived from two types of dorsal root ganglia (DRG) neurons: one kind of polymodal nociceptors containing galanin (Gal) and one type of pruriceptors expressing neurotensin (Nts). ...
Here, we use the type 1 herpes simplex virus H129 strain to trace the neural networks derived from two types of dorsal root ganglia (DRG) ne …
86 results