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Page 1
A CACNA1C variant associated with cardiac arrhythmias provides mechanistic insights in the calmodulation of L-type Ca2+ channels.
J Biol Chem. 2022 Dec;298(12):102632. doi: 10.1016/j.jbc.2022.102632. Epub 2022 Oct 21.
J Biol Chem. 2022.
PMID: 36273583
Free PMC article.
Novel Gain-of-Function Variant in CACNA1C Associated With Timothy Syndrome, Multiple Accessory Pathways, and Noncompaction Cardiomyopathy.
Kelu Bisabu K, Zhao J, Mokrane AE, Segura É, Marsolais M, Grondin S, Naas E, Gagnon J, Cadrin-Tourigny J, Aguilar M, Mongeon FP, Talajic M, Parent L, Tadros R.
Kelu Bisabu K, et al. Among authors: segura e.
Circ Genom Precis Med. 2020 Dec;13(6):e003123. doi: 10.1161/CIRCGEN.120.003123. Epub 2020 Nov 14.
Circ Genom Precis Med. 2020.
PMID: 33191761
No abstract available.
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An ancestral MAGUK protein supports the modulation of mammalian voltage-gated Ca2+ channels through a conserved CaVβ-like interface.
Segura E, Mehta A, Marsolais M, Quan XR, Zhao J, Sauvé R, Spafford JD, Parent L.
Segura E, et al.
Biochim Biophys Acta Biomembr. 2020 Nov 1;1862(11):183439. doi: 10.1016/j.bbamem.2020.183439. Epub 2020 Aug 16.
Biochim Biophys Acta Biomembr. 2020.
PMID: 32814116
Free article.
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Proteolytic cleavage of the hydrophobic domain in the CaVα2δ1 subunit improves assembly and activity of cardiac CaV1.2 channels.
Segura E, Bourdin B, Tétreault MP, Briot J, Allen BG, Mayer G, Parent L.
Segura E, et al.
J Biol Chem. 2017 Jun 30;292(26):11109-11124. doi: 10.1074/jbc.M117.784355. Epub 2017 May 11.
J Biol Chem. 2017.
PMID: 28495885
Free PMC article.
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Investigating the Impact of Electrostatic Interactions on Calmodulin Binding and Ca2+-Dependent Activation of the Calcium-Gated Potassium SK4 Channel.
Segura É, Zhao J, Broszczak M, Audet F, Sauvé R, Parent L.
Segura É, et al.
Int J Mol Sci. 2024 Apr 11;25(8):4255. doi: 10.3390/ijms25084255.
Int J Mol Sci. 2024.
PMID: 38673845
Free PMC article.
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Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry.
Bourdin B, Segura E, Tétreault MP, Lesage S, Parent L.
Bourdin B, et al. Among authors: segura e.
J Vis Exp. 2016 Sep 28;(115):54732. doi: 10.3791/54732.
J Vis Exp. 2016.
PMID: 27768059
Free PMC article.
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Identification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity.
Tétreault MP, Bourdin B, Briot J, Segura E, Lesage S, Fiset C, Parent L.
Tétreault MP, et al. Among authors: segura e.
J Biol Chem. 2016 Feb 26;291(9):4826-43. doi: 10.1074/jbc.M115.692178. Epub 2016 Jan 7.
J Biol Chem. 2016.
PMID: 26742847
Free PMC article.
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