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Did you mean yangpu duan (25 results)?
Lysine catabolism reprograms tumour immunity through histone crotonylation.
Yuan H, Wu X, Wu Q, Chatoff A, Megill E, Gao J, Huang T, Duan T, Yang K, Jin C, Yuan F, Wang S, Zhao L, Zinn PO, Abdullah KG, Zhao Y, Snyder NW, Rich JN. Yuan H, et al. Nature. 2023 May;617(7962):818-826. doi: 10.1038/s41586-023-06061-0. Epub 2023 May 17. Nature. 2023. PMID: 37198486 Free PMC article.
CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.
Liu D, Duan L, Rodda LB, Lu E, Xu Y, An J, Qiu L, Liu F, Looney MR, Yang Z, Allen CDC, Li Z, Marson A, Cyster JG. Liu D, et al. Science. 2022 Feb 11;375(6581):eabi5965. doi: 10.1126/science.abi5965. Epub 2022 Feb 11. Science. 2022. PMID: 35143305 Free PMC article.
CD55 is a CD97 ligand, and cDC2 interaction with CD55-expressing red blood cells (RBCs) under shear stress conditions caused extraction of the regulatory CD97 N-terminal fragment. Deficiency in CD55-CD97 signaling led to loss of splenic cDC2s into the circulation and defec …
CD55 is a CD97 ligand, and cDC2 interaction with CD55-expressing red blood cells (RBCs) under shear stress conditions caused extraction of t …
Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury.
Yang HH, Jiang HL, Tao JH, Zhang CY, Xiong JB, Yang JT, Liu YB, Zhong WJ, Guan XX, Duan JX, Zhang YF, Liu SK, Jiang JX, Zhou Y, Guan CX. Yang HH, et al. Exp Mol Med. 2022 Nov;54(11):2077-2091. doi: 10.1038/s12276-022-00889-8. Epub 2022 Nov 28. Exp Mol Med. 2022. PMID: 36443565 Free PMC article.
We found an accumulation of mitochondrial citrate (citrate(mt)) in lipopolysaccharide (LPS)-treated AECs because of the downregulation of Idh3alpha and citrate carrier (CIC, also known as Slc25a1). shRNA- or inhibitor-mediated inhibition of Idh3alpha and Slc25a1 induced citrate(m …
We found an accumulation of mitochondrial citrate (citrate(mt)) in lipopolysaccharide (LPS)-treated AECs because of the downregulation of Id …
CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis.
Lv JJ, Wang H, Zhang C, Zhang TJ, Wei HL, Liu ZK, Ma YH, Yang Z, He Q, Wang LJ, Duan LL, Chen ZN, Bian H. Lv JJ, et al. Circ Res. 2024 Jan 19;134(2):165-185. doi: 10.1161/CIRCRESAHA.123.323223. Epub 2024 Jan 3. Circ Res. 2024. PMID: 38166463 Free article.
Consistent with the reduced size of the necrotic core, myeloid-specific CD147 deficiency diminished the susceptibility of iNOS-mediated late apoptosis, accompanied by enhanced efferocytotic capacity mediated by increased secretion of GAS6 (growth arrest-specific 6) in proi …
Consistent with the reduced size of the necrotic core, myeloid-specific CD147 deficiency diminished the susceptibility of iNOS-mediat …
The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease.
Chu H, Duan Y, Lang S, Jiang L, Wang Y, Llorente C, Liu J, Mogavero S, Bosques-Padilla F, Abraldes JG, Vargas V, Tu XM, Yang L, Hou X, Hube B, Stärkel P, Schnabl B. Chu H, et al. J Hepatol. 2020 Mar;72(3):391-400. doi: 10.1016/j.jhep.2019.09.029. Epub 2019 Oct 10. J Hepatol. 2020. PMID: 31606552 Free PMC article. Clinical Trial.
CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer.
Zhang M, Yang W, Wang P, Deng Y, Dong YT, Liu FF, Huang R, Zhang P, Duan YQ, Liu XD, Lin D, Chu Q, Zhong B. Zhang M, et al. Nat Commun. 2020 Nov 30;11(1):6119. doi: 10.1038/s41467-020-19973-6. Nat Commun. 2020. PMID: 33257678 Free PMC article.
CCL7 exhibits high expression in NSCLC tumor tissues and is positively correlated with the infiltration of cDC1 in the TME and the overall survival of NSCLC patients. CCL7 deficiency impairs the infiltration of cDC1 in the TME and the subsequent expansion of CD8(+) and CD4 …
CCL7 exhibits high expression in NSCLC tumor tissues and is positively correlated with the infiltration of cDC1 in the TME and the overall s …
Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer.
Yang H, Zhang X, Lao M, Sun K, He L, Xu J, Duan Y, Chen Y, Ying H, Li M, Guo C, Lu Q, Wang S, Su W, Liang T, Bai X. Yang H, et al. Cell Death Differ. 2023 Feb;30(2):560-575. doi: 10.1038/s41418-022-01102-z. Epub 2022 Dec 20. Cell Death Differ. 2023. PMID: 36539510 Free PMC article.
Clinically, the expression of USP8 showed a significant association with the tumor-node-metastasis stage in multiple patient-derived cohorts of pancreatic cancer. Meanwhile, USP8 deficiency could reduce tumor invasion and migration and tumor size in an immunity-dependent m …
Clinically, the expression of USP8 showed a significant association with the tumor-node-metastasis stage in multiple patient-derived cohorts …
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC. Zhang W, et al. Science. 2015 Jun 5;348(6239):1160-3. doi: 10.1126/science.aaa1356. Epub 2015 Apr 30. Science. 2015. PMID: 25931448 Free PMC article.
Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. Here, we report on the generation of a human WS model in human embryonic stem cells (ESCs). ...
Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. Here, we report on the generation of a human WS …
Deficiency of Transcription Factor Sp1 Contributes to Hypertrophic Cardiomyopathy.
Zhang F, Zhou H, Xue J, Zhang Y, Zhou L, Leng J, Fang G, Liu Y, Wang Y, Liu H, Wu Y, Qi L, Duan R, He X, Wang Y, Liu Y, Li L, Yang J, Liang D, Chen YH. Zhang F, et al. Circ Res. 2024 Feb 2;134(3):290-306. doi: 10.1161/CIRCRESAHA.123.323272. Epub 2024 Jan 10. Circ Res. 2024. PMID: 38197258 Free article.
Furthermore, SP1 overexpression suppressed the development of HCM in the mutant allele of Myh6 R404Q/+ mice and also reversed the hypertrophic phenotype of HCM hiPSC-CMs. CONCLUSIONS: Our study demonstrates that SP1 deficiency leads to HCM. SP1 overexpression exhibits sign …
Furthermore, SP1 overexpression suppressed the development of HCM in the mutant allele of Myh6 R404Q/+ mice and also reversed the hypertroph …
235 results