With the development of activated sludge model, the simulation software for the design and operation of wastewater treatment plant (WWTP) was produced and has been widely used. The dynamic change of the quality and flow of influent are major factors causing the unstable operation of wastewater treatment process. As a basic model, ASM1 model was used for the simulation of activated sludge process, and double exponential model was selected for the simulation of secondary sedimentation tank. The influences of influent change to the aeration tank and secondary sedimentation tank were investigated, and the relationship among influent change, the quality of effluent and the level of sludge blanket in secondary sedimentation tank was established. On the basis of the simulation results, the operation of the WWTP could be adjusted under the dynamic change of the influent. Furthermore, the controlling strategy combined the feed-forward on the influent flow and the feedback on the level of sludge blanket in the secondary sedimentation tank was studied.