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Page 1
Molecular coevolution of coagulation factor VIII and von Willebrand factor.
Zakas PM, Coyle CW, Brehm A, Bayer M, Solecka-Witulska B, Radford CE, Brown C, Nesbitt K, Dwyer C, Kannicht C, Spencer HT, Gaucher EA, Doering CB, Lillicrap D. Zakas PM, et al. Blood Adv. 2021 Feb 9;5(3):812-822. doi: 10.1182/bloodadvances.2020002971. Blood Adv. 2021. PMID: 33560395 Free PMC article.
Using sequence analysis and biochemical characterization of recombinant ancestral von Willebrand factor (VWF) and coagulation factor VIII (FVIII), we investigated the evolution of the essential macromolecular FVIII/VWF complex. ...
Using sequence analysis and biochemical characterization of recombinant ancestral von Willebrand factor (VWF) and coagulation factor …
Signaling events underlying thrombus formation.
Jackson SP, Nesbitt WS, Kulkarni S. Jackson SP, et al. J Thromb Haemost. 2003 Jul;1(7):1602-12. doi: 10.1046/j.1538-7836.2003.00267.x. J Thromb Haemost. 2003. PMID: 12871297 Free article. Review.
Recent in vivo studies have highlighted the dynamic and complex nature of platelet thrombus growth and the requirement for multiple adhesive receptor-ligand interactions in this process. In particular, the importance of von Willebrand factor (VWF) in promoting both primary …
Recent in vivo studies have highlighted the dynamic and complex nature of platelet thrombus growth and the requirement for multiple adhesive …
Elastomeric microvalve geometry affects haemocompatibility.
Szydzik C, Brazilek RJ, Khoshmanesh K, Akbaridoust F, Knoerzer M, Thurgood P, Muir I, Marusic I, Nandurkar H, Mitchell A, Nesbitt WS. Szydzik C, et al. Lab Chip. 2018 Jun 12;18(12):1778-1792. doi: 10.1039/c7lc01320e. Lab Chip. 2018. PMID: 29789838
Using a comprehensive investigation of blood function, we describe a hierarchy of haemocompatibility as a function of microvalve geometry and identify a "normally-closed" v-gate pneumatic microvalve design that minimally affects blood plasma fibrinogen and von Willebrand f …
Using a comprehensive investigation of blood function, we describe a hierarchy of haemocompatibility as a function of microvalve geometry an …
von Willebrand Factor Is a Critical Mediator of Deep Vein Thrombosis in a Mouse Model of Diet-Induced Obesity.
Michels A, Dwyer CN, Mewburn J, Nesbitt K, Kawecki C, Lenting P, Swystun LL, Lillicrap D. Michels A, et al. Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2860-2874. doi: 10.1161/ATVBAHA.120.314690. Epub 2020 Sep 24. Arterioscler Thromb Vasc Biol. 2020. PMID: 32967458 Free article.
OBJECTIVE: Obesity is characterized by chronic low-grade inflammation and consequentially a hypercoagulable state, associating with an increased incidence of venous thromboembolism. Increased VWF (von Willebrand factor) plasma concentration and procoagulant function are in …
OBJECTIVE: Obesity is characterized by chronic low-grade inflammation and consequentially a hypercoagulable state, associating with an incre …
The mechanistic and structural role of von Willebrand factor in endotoxemia-enhanced deep vein thrombosis in mice.
Choi SJ, Dwyer CN, Rapkin L, Cormier M, Hindmarch CCT, Nesbitt K, Michels A, Hopman W, Swystun LL, Lillicrap D. Choi SJ, et al. J Thromb Haemost. 2023 Mar;21(3):586-598. doi: 10.1016/j.jtha.2022.11.022. Epub 2022 Dec 22. J Thromb Haemost. 2023. PMID: 36696220 Free article.
OBJECTIVES: The objective of this study was to investigate the role of the von Willebrand factor (VWF) in inflammation-associated venous thrombosis. ...
OBJECTIVES: The objective of this study was to investigate the role of the von Willebrand factor (VWF) in inflammation-associated ven …
Abnormal von Willebrand factor secretion, factor VIII stabilization and thrombus dynamics in type 2N von Willebrand disease mice.
Swystun LL, Georgescu I, Mewburn J, Deforest M, Nesbitt K, Hebert K, Dwyer C, Brown C, Notley C, Lillicrap D. Swystun LL, et al. J Thromb Haemost. 2017 Aug;15(8):1607-1619. doi: 10.1111/jth.13749. Epub 2017 Jul 17. J Thromb Haemost. 2017. PMID: 28581694 Free article.
Essentials Type 2N von Willebrand disease involves impaired von Willebrand factor to factor VIII binding. ...Type 2N von Willebrand disease mice exhibit unstable venous hemostatic thrombi. ...
Essentials Type 2N von Willebrand disease involves impaired von Willebrand factor to factor VIII binding. ...Type 2N von …
Novel cysteine substitution p.(Cys1084Tyr) causes variable expressivity of qualitative and quantitative VWF defects.
Rawley O, Swystun LL, Brown C, Nesbitt K, Rand M, Hossain T, Klaassen R, James PD, Carcao MD, Lillicrap D. Rawley O, et al. Blood Adv. 2022 May 10;6(9):2908-2919. doi: 10.1182/bloodadvances.2021005928. Blood Adv. 2022. PMID: 35020809 Free PMC article.
von Willebrand factor (VWF) is an extremely cysteine-rich multimeric protein that is essential for maintaining normal hemostasis. ...In this study, we investigated and characterized the molecular and pathogenic mechanisms through which a novel cysteine variant p.(Cys1084Ty …
von Willebrand factor (VWF) is an extremely cysteine-rich multimeric protein that is essential for maintaining normal hemostasis. ... …
Application of a strain rate gradient microfluidic device to von Willebrand's disease screening.
Brazilek RJ, Tovar-Lopez FJ, Wong AKT, Tran H, Davis AS, McFadyen JD, Kaplan Z, Chunilal S, Jackson SP, Nandurkar H, Mitchell A, Nesbitt WS. Brazilek RJ, et al. Lab Chip. 2017 Jul 25;17(15):2595-2608. doi: 10.1039/c7lc00498b. Lab Chip. 2017. PMID: 28660968
Von Willebrand's disease (VWD) is the most common inherited bleeding disorder caused by either quantitative or qualitative defects of von Willebrand factor (VWF). ...
Von Willebrand's disease (VWD) is the most common inherited bleeding disorder caused by either quantitative or qualitative defects of …
An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients.
Zainal Abidin NA, Poon EKW, Szydzik C, Timofeeva M, Akbaridoust F, Brazilek RJ, Tovar Lopez FJ, Ma X, Lav C, Marusic I, Thompson PE, Mitchell A, Ooi ASH, Hamilton JR, Nesbitt WS. Zainal Abidin NA, et al. BMC Biol. 2022 Mar 24;20(1):73. doi: 10.1186/s12915-022-01274-7. BMC Biol. 2022. PMID: 35331224 Free PMC article.
RESULTS: Using a generalized Newtonian computational model in combination with microfluidic models of flow acceleration and quasi-homogenous extensional strain, we demonstrate that platelets directly mechano-sense acute changes in free-flow extensional strain independent of shear …
RESULTS: Using a generalized Newtonian computational model in combination with microfluidic models of flow acceleration and quasi-homogenous …
37 results