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Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials.
Mayer-Hamblett N, Ratjen F, Russell R, Donaldson SH, Riekert KA, Sawicki GS, Odem-Davis K, Young JK, Rosenbluth D, Taylor-Cousar JL, Goss CH, Retsch-Bogart G, Clancy JP, Genatossio A, O'Sullivan BP, Berlinski A, Millard SL, Omlor G, Wyatt CA, Moffett K, Nichols DP, Gifford AH; SIMPLIFY Study Group. Mayer-Hamblett N, et al. Lancet Respir Med. 2023 Apr;11(4):329-340. doi: 10.1016/S2213-2600(22)00434-9. Epub 2022 Nov 4. Lancet Respir Med. 2023. PMID: 36343646 Free PMC article. Clinical Trial.
The SIMPLIFY study aimed to assess the effects of discontinuing nebulised hypertonic saline or dornase alfa in individuals using the CFTR modulator elexacaftor plus tezacaftor plus ivacaftor (ETI). ...We included individuals with cystic fibrosis aged 12-17 years with perce …
The SIMPLIFY study aimed to assess the effects of discontinuing nebulised hypertonic saline or dornase alfa in individuals using the …
Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI.
Kilari S, Sharma A, Zhao C, Singh A, Cai C, Simeon M, van Wijnen AJ, Misra S. Kilari S, et al. Transl Res. 2021 Sep;235:32-47. doi: 10.1016/j.trsl.2021.03.005. Epub 2021 Mar 9. Transl Res. 2021. PMID: 33711514 Free PMC article.
Twenty eight days later, 100-L of iodinated contrast (CI group) or saline (S group) was given via the carotid artery. Whole-transcriptome RNA-sequencing (RNA-Seq) analysis of the kidneys was performed at day 2. Mice received either 50-L of saline ip or terazosin (2 …
Twenty eight days later, 100-L of iodinated contrast (CI group) or saline (S group) was given via the carotid artery. Whole-transcrip …
Increased fibrotic signaling in a murine model for intra-arterial contrast-induced acute kidney injury.
Sharma A, Kilari S, Cai C, Simeon ML, Misra S. Sharma A, et al. Am J Physiol Renal Physiol. 2020 May 1;318(5):F1210-F1219. doi: 10.1152/ajprenal.00004.2020. Epub 2020 Mar 23. Am J Physiol Renal Physiol. 2020. PMID: 32200666 Free PMC article.

Twenty-eight days later, 100 muL of contrast agent [iodixanol (320 mg/mL)] or saline were administered via the carotid artery. Two days after contrast administration, compared with saline, average serum creatinine was significantly elevated (P < 0.05). In the cor

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Twenty-eight days later, 100 muL of contrast agent [iodixanol (320 mg/mL)] or saline were administered via the carotid artery. Two da …
11C-Labeling of Aryl Ketones as Candidate Histamine Subtype-3 Receptor PET Radioligands through Pd(0)-Mediated 11C-Carbonylative Coupling.
Siméon FG, Culligan WJ, Lu S, Pike VW. Siméon FG, et al. Molecules. 2017 May 12;22(5):792. doi: 10.3390/molecules22050792. Molecules. 2017. PMID: 28498336 Free PMC article.
Radiosynthesis was successfully performed on a platform equipped with a mini-autoclave and a liquid handling robotic arm, within a lead-shielded hot-cell. Candidate radioligands were readily formulated in saline containing ethanol (10%, v/v) and ascorbic acid (0.5 mg/10 mL …
Radiosynthesis was successfully performed on a platform equipped with a mini-autoclave and a liquid handling robotic arm, within a lead-shie …
Intramyometrial vasopressin as a haemostatic agent during myomectomy.
Frederick J, Fletcher H, Simeon D, Mullings A, Hardie M. Frederick J, et al. Br J Obstet Gynaecol. 1994 May;101(5):435-7. doi: 10.1111/j.1471-0528.1994.tb11918.x. Br J Obstet Gynaecol. 1994. PMID: 8018617 Clinical Trial.
INTERVENTION: Myomectomy was performed after the intramyometrial injection of either 20 units vasopressin diluted to 20 ml in normal saline or placebo (20 ml normal saline). MAIN OUTCOME MEASURES: The efficacy of vasopressin was measured by comparing pre- and post-o …
INTERVENTION: Myomectomy was performed after the intramyometrial injection of either 20 units vasopressin diluted to 20 ml in normal sali …
Expression and activation of matrix metalloproteinases in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.
Siméon A, Monier F, Emonard H, Gillery P, Birembaut P, Hornebeck W, Maquart FX. Siméon A, et al. J Invest Dermatol. 1999 Jun;112(6):957-64. doi: 10.1046/j.1523-1747.1999.00606.x. J Invest Dermatol. 1999. PMID: 10383745 Free article.
Wound chambers were inserted under the skin of Sprague-Dawley rats and received serial injections of either 2 mg glycyl-L-histidyl-L-lysine-Cu(II) or the same volume of saline. The wound fluid and the neosynthetized connective tissue deposited in the chambers were collecte …
Wound chambers were inserted under the skin of Sprague-Dawley rats and received serial injections of either 2 mg glycyl-L-histidyl-L-lysine- …
Prevention of canine ocular thelaziosis (Thelazia callipaeda) with a combination of milbemycin oxime and afoxolaner (Nexgard Spectra®) in endemic areas in France and Spain.
Lebon W, Guillot J, Álvarez MJ, Antonio Bazaga J, Cortes-Dubly ML, Dumont P, Eberhardt M, Gómez H, Pennant O, Siméon N, Beugnet F, Halos L. Lebon W, et al. Parasite. 2019;26:1. doi: 10.1051/parasite/2019001. Epub 2019 Jan 15. Parasite. 2019. PMID: 30644355 Free PMC article.
When the presence of nematodes was confirmed, the conjunctival fornix was flushed with a saline solution for parasite recovery and counting, and the dogs were treated appropriately. ...
When the presence of nematodes was confirmed, the conjunctival fornix was flushed with a saline solution for parasite recovery …
A randomized comparison of vasopressin and tourniquet as hemostatic agents during myomectomy.
Fletcher H, Frederick J, Hardie M, Simeon D. Fletcher H, et al. Obstet Gynecol. 1996 Jun;87(6):1014-8. doi: 10.1016/0029-7844(96)00071-3. Obstet Gynecol. 1996. PMID: 8649682 Clinical Trial.
Myomectomy was performed after either the perivascular injection of 20 U of vasopressin diluted to 20 mL with normal saline or with the use of a Foley catheter tourniquet around both uterine vessels. ...
Myomectomy was performed after either the perivascular injection of 20 U of vasopressin diluted to 20 mL with normal saline or with t …