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Plant glycoengineering for designing next-generation vaccines and therapeutic proteins.
Strasser R. Strasser R. Biotechnol Adv. 2023 Oct;67:108197. doi: 10.1016/j.biotechadv.2023.108197. Epub 2023 Jun 12. Biotechnol Adv. 2023. PMID: 37315875 Free article. Review.
Glycoengineering approaches are used to eliminate unwanted glycan modifications and to facilitate the coordinated expression of glycosylation enzymes or whole metabolic pathways to furnish glycans with distinct modifications. The formation of tailored glycans enables struc …
Glycoengineering approaches are used to eliminate unwanted glycan modifications and to facilitate the coordinated expression of glycosylatio …
Distinct patterns of SARS-CoV-2 BA.2.87.1 and JN.1 variants in immune evasion, antigenicity, and cell-cell fusion.
Li P, Liu Y, Faraone JN, Hsu CC, Chamblee M, Zheng Y-M, Carlin C, Bednash JS, Horowitz JC, Mallampalli RK, Saif LJ, Oltz EM, Jones D, Li J, Gumina RJ, Liu S-L. Li P, et al. mBio. 2024 May 8;15(5):e0075124. doi: 10.1128/mbio.00751-24. Epub 2024 Apr 9. mBio. 2024. PMID: 38591890 Free PMC article.
Antigenic differences between BA.2.87.1 and other earlier variants yield critical information not only for antibody evasion but also for viral evolution. In conclusion, this study furnishes timely insights into the spike biology and immune escape of the emerging variants B …
Antigenic differences between BA.2.87.1 and other earlier variants yield critical information not only for antibody evasion but also for vir …
The Anglo-Saxon migration and the formation of the early English gene pool.
Gretzinger J, Sayer D, Justeau P, Altena E, Pala M, Dulias K, Edwards CJ, Jodoin S, Lacher L, Sabin S, Vågene ÅJ, Haak W, Ebenesersdóttir SS, Moore KHS, Radzeviciute R, Schmidt K, Brace S, Bager MA, Patterson N, Papac L, Broomandkhoshbacht N, Callan K, Harney É, Iliev L, Lawson AM, Michel M, Stewardson K, Zalzala F, Rohland N, Kappelhoff-Beckmann S, Both F, Winger D, Neumann D, Saalow L, Krabath S, Beckett S, Van Twest M, Faulkner N, Read C, Barton T, Caruth J, Hines J, Krause-Kyora B, Warnke U, Schuenemann VJ, Barnes I, Dahlström H, Clausen JJ, Richardson A, Popescu E, Dodwell N, Ladd S, Phillips T, Mortimer R, Sayer F, Swales D, Stewart A, Powlesland D, Kenyon R, Ladle L, Peek C, Grefen-Peters S, Ponce P, Daniels R, Spall C, Woolcock J, Jones AM, Roberts AV, Symmons R, Rawden AC, Cooper A, Bos KI, Booth T, Schroeder H, Thomas MG, Helgason A, Richards MB, Reich D, Krause J, Schiffels S. Gretzinger J, et al. Nature. 2022 Oct;610(7930):112-119. doi: 10.1038/s41586-022-05247-2. Epub 2022 Sep 21. Nature. 2022. PMID: 36131019 Free PMC article.
We show that women with immigrant ancestry were more often furnished with grave goods than women with local ancestry, whereas men with weapons were as likely not to be of immigrant ancestry. ...
We show that women with immigrant ancestry were more often furnished with grave goods than women with local ancestry, whereas men wit …
ImageJ for Partially and Fully Automated Analysis of Trypanosome Micrographs.
Wheeler RJ. Wheeler RJ. Methods Mol Biol. 2020;2116:385-408. doi: 10.1007/978-1-0716-0294-2_24. Methods Mol Biol. 2020. PMID: 32221933
These are not presented as strict methods, but are instead described in detail with the intention of furnishing the reader with the ability to "hack" the scripts for their own needs or write their own scripts for partially and fully automated quantitation of trypanosomes f …
These are not presented as strict methods, but are instead described in detail with the intention of furnishing the reader with the a …
Late-stage modification of peptides and proteins at cysteine with diaryliodonium salts.
Byrne SA, Bedding MJ, Corcilius L, Ford DJ, Zhong Y, Franck C, Larance M, Mackay JP, Payne RJ. Byrne SA, et al. Chem Sci. 2021 Sep 30;12(42):14159-14166. doi: 10.1039/d1sc03127a. eCollection 2021 Nov 3. Chem Sci. 2021. PMID: 34760200 Free PMC article.
Herein, we report a novel method for the chemoselective late-stage modification of peptides and proteins at cysteine in aqueous buffer with suitably functionalised diaryliodonium salts, furnishing stable thioether-linked synthetic conjugates. The power of this new platform …
Herein, we report a novel method for the chemoselective late-stage modification of peptides and proteins at cysteine in aqueous buffer with …
The importance of high-density lipoproteins for paraoxonase-1 secretion, stability, and activity.
James RW, Deakin SP. James RW, et al. Free Radic Biol Med. 2004 Dec 15;37(12):1986-94. doi: 10.1016/j.freeradbiomed.2004.08.012. Free Radic Biol Med. 2004. PMID: 15544917 Review.
The association of paraoxonase-1 (PON1) with high-density lipoproteins (HDL) is a prerequisite for maintaining normal serum activity of the enzyme. The lipoprotein furnishes an amphipathic environment to shield the hydrophobic, N-terminal region of the enzyme, and such an …
The association of paraoxonase-1 (PON1) with high-density lipoproteins (HDL) is a prerequisite for maintaining normal serum activity of the …
Overcoming challenges to support us resumption of high specific activity cobalt-60.
Howard RH, Reichenberger MA, Urban-Klaehn JM, Peterson-Droogh JL, Brookman JV, Gross B, Tyler C, Navarro J, Lillo M, Zillmer A. Howard RH, et al. Appl Radiat Isot. 2021 Mar;169:109494. doi: 10.1016/j.apradiso.2020.109494. Epub 2020 Dec 11. Appl Radiat Isot. 2021. PMID: 33360267
These efforts include performing accurate production predictions, experimentally validating predictions with assay measurements, shipping with the Orano-furnished Battelle Energy Alliance Research Reactor shipping package, and disassembling capsules at the isotope vendor s …
These efforts include performing accurate production predictions, experimentally validating predictions with assay measurements, shipping wi …
Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B'.
Procopiou G, Aggarwal P, Newton AF, Richards D, Mellor IR, Harbottle G, Stockman RA. Procopiou G, et al. Chem Commun (Camb). 2014 Dec 18;50(97):15355-7. doi: 10.1039/c4cc07287a. Epub 2014 Oct 28. Chem Commun (Camb). 2014. PMID: 25348081
A tandem cyclisation established the entire core of the structure in a single transformation as well as the required 2,5-anti stereochemistry. Two-directional synthesis was used to furnish the cyclisation precursor 2, as in each of the subsequent steps towards the natural …
A tandem cyclisation established the entire core of the structure in a single transformation as well as the required 2,5-anti stereochemistr …
Acrylamide formation in different foods and potential strategies for reduction.
Stadler RH. Stadler RH. Adv Exp Med Biol. 2005;561:157-69. doi: 10.1007/0-387-24980-X_13. Adv Exp Med Biol. 2005. PMID: 16438297 Review.
Decarboxylation of the resulting Schiff base is a key step, and the reaction product may either furnish acrylamide directly or via 3-aminopropionamide. An alternative proposal is that the corresponding decarboxylated Amadori compound may release acrylamide by a beta-elimin …
Decarboxylation of the resulting Schiff base is a key step, and the reaction product may either furnish acrylamide directly or via 3- …
Reproducibilty of partial weight bearing.
Malviya A, Richards J, Jones RK, Udwadia A, Doyle J. Malviya A, et al. Injury. 2005 Apr;36(4):556-9. doi: 10.1016/j.injury.2004.10.004. Epub 2005 Jan 22. Injury. 2005. PMID: 15755439
35 results