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1990 1
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2008 1
2009 2
2010 3
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2014 2
2015 8
2016 5
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68 results

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Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial.
Cortes J, Cescon DW, Rugo HS, Nowecki Z, Im SA, Yusof MM, Gallardo C, Lipatov O, Barrios CH, Holgado E, Iwata H, Masuda N, Otero MT, Gokmen E, Loi S, Guo Z, Zhao J, Aktan G, Karantza V, Schmid P; KEYNOTE-355 Investigators. Cortes J, et al. Lancet. 2020 Dec 5;396(10265):1817-1828. doi: 10.1016/S0140-6736(20)32531-9. Lancet. 2020. PMID: 33278935 Clinical Trial.
METHODS: In this randomised, placebo-controlled, double-blind, phase 3 trial, done in 209 sites in 29 countries, we randomly assigned patients 2:1 with untreated locally recurrent inoperable or metastatic triple-negative breast cancer using a block method (block size of six) and …
METHODS: In this randomised, placebo-controlled, double-blind, phase 3 trial, done in 209 sites in 29 countries, we randomly assigned patien …
The Methods of Choice for Extracellular Vesicles (EVs) Characterization.
Szatanek R, Baj-Krzyworzeka M, Zimoch J, Lekka M, Siedlar M, Baran J. Szatanek R, et al. Int J Mol Sci. 2017 May 29;18(6):1153. doi: 10.3390/ijms18061153. Int J Mol Sci. 2017. PMID: 28555055 Free PMC article. Review.
These membrane-enclosed spherical structures are secreted by almost every cell type and are engaged in the transport of cellular content (cargo) from parental to target cells. ...
These membrane-enclosed spherical structures are secreted by almost every cell type and are engaged in the transport of cellular cont …
Management of patients with advanced prostate cancer-metastatic and/or castration-resistant prostate cancer: Report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022.
Gillessen S, Bossi A, Davis ID, de Bono J, Fizazi K, James ND, Mottet N, Shore N, Small E, Smith M, Sweeney CJ, Tombal B, Antonarakis ES, Aparicio AM, Armstrong AJ, Attard G, Beer TM, Beltran H, Bjartell A, Blanchard P, Briganti A, Bristow RG, Bulbul M, Caffo O, Castellano D, Castro E, Cheng HH, Chi KN, Chowdhury S, Clarke CS, Clarke N, Daugaard G, De Santis M, Duran I, Eeles R, Efstathiou E, Efstathiou J, Ekeke ON, Evans CP, Fanti S, Feng FY, Fonteyne V, Fossati N, Frydenberg M, George D, Gleave M, Gravis G, Halabi S, Heinrich D, Herrmann K, Higano C, Hofman MS, Horvath LG, Hussain M, Jereczek-Fossa BA, Jones R, Kanesvaran R, Kellokumpu-Lehtinen PL, Khauli RB, Klotz L, Kramer G, Leibowitz R, Logothetis C, Mahal B, Maluf F, Mateo J, Matheson D, Mehra N, Merseburger A, Morgans AK, Morris MJ, Mrabti H, Mukherji D, Murphy DG, Murthy V, Nguyen PL, Oh WK, Ost P, O'Sullivan JM, Padhani AR, Pezaro CJ, Poon DMC, Pritchard CC, Rabah DM, Rathkopf D, Reiter RE, Rubin MA, Ryan CJ, Saad F, Sade JP, Sartor O, Scher HI, Sharifi N, Skoneczna I, Soule H, Spratt DE, Srinivas S, Sternberg CN, Steuber T, Suzuki H, Sydes MR, Taplin ME, Tilki D, Türkeri L, Turco F, Uemura H, Uemura H, Ürün Y, Vale CL, … See abstract for full author list ➔ Gillessen S, et al. Eur J Cancer. 2023 May;185:178-215. doi: 10.1016/j.ejca.2023.02.018. Epub 2023 Mar 3. Eur J Cancer. 2023. PMID: 37003085 Free article.
Metabolic networks of the human gut microbiota.
Selber-Hnatiw S, Sultana T, Tse W, Abdollahi N, Abdullah S, Al Rahbani J, Alazar D, Alrumhein NJ, Aprikian S, Arshad R, Azuelos JD, Bernadotte D, Beswick N, Chazbey H, Church K, Ciubotaru E, D'Amato L, Del Corpo T, Deng J, Di Giulio BL, Diveeva D, Elahie E, Frank JGM, Furze E, Garner R, Gibbs V, Goldberg-Hall R, Goldman CJ, Goltsios FF, Gorjipour K, Grant T, Greco B, Guliyev N, Habrich A, Hyland H, Ibrahim N, Iozzo T, Jawaheer-Fenaoui A, Jaworski JJ, Jhajj MK, Jones J, Joyette R, Kaudeer S, Kelley S, Kiani S, Koayes M, Kpata AJAL, Maingot S, Martin S, Mathers K, McCullogh S, McNamara K, Mendonca J, Mohammad K, Momtaz SA, Navaratnarajah T, Nguyen-Duong K, Omran M, Ortiz A, Patel A, Paul-Cole K, Plaisir PA, Porras Marroquin JA, Prevost A, Quach A, Rafal AJ, Ramsarun R, Rhnima S, Rili L, Safir N, Samson E, Sandiford RR, Secondi S, Shahid S, Shahroozi M, Sidibé F, Smith M, Sreng Flores AM, Suarez Ybarra A, Sénéchal R, Taifour T, Tang L, Trapid A, Tremblay Potvin M, Wainberg J, Wang DN, Weissenberg M, White A, Wilkinson G, Williams B, Wilson JR, Zoppi J, Zouboulakis K, Gamberi C. Selber-Hnatiw S, et al. Microbiology (Reading). 2020 Feb;166(2):96-119. doi: 10.1099/mic.0.000853. Microbiology (Reading). 2020. PMID: 31799915 Free article. Review.
A systems-level framework for anti-epilepsy drug discovery.
Johnson MR, Kaminski RM. Johnson MR, et al. Neuropharmacology. 2020 Jun 15;170:107868. doi: 10.1016/j.neuropharm.2019.107868. Epub 2019 Nov 28. Neuropharmacology. 2020. PMID: 31785261 Review.
The approach offers an exciting and flexible framework for future drug discovery in epilepsy, and is applicable to any disease for which appropriate cell-type and disease-context specific data exist. This article is part of the special issue entitled 'New Epilepsy Therapie …
The approach offers an exciting and flexible framework for future drug discovery in epilepsy, and is applicable to any disease for which app …
Graphene-based tunable hyperbolic microcavity.
Dudek M, Kowerdziej R, Pianelli A, Parka J. Dudek M, et al. Sci Rep. 2021 Jan 8;11(1):74. doi: 10.1038/s41598-020-80022-9. Sci Rep. 2021. PMID: 33420197 Free PMC article.
Finally, numerical analysis indicated that a topological transition between elliptic and type II hyperbolic dispersion could be actively switched. The proposed scheme represents a remarkably versatile platform for the mid-infrared wave manipulation and may find application …
Finally, numerical analysis indicated that a topological transition between elliptic and type II hyperbolic dispersion could be activ …
Neuroprotective effects of PPARalpha in retinopathy of type 1 diabetes.
Pearsall EA, Cheng R, Matsuzaki S, Zhou K, Ding L, Ahn B, Kinter M, Humphries KM, Quiambao AB, Farjo RA, Ma JX. Pearsall EA, et al. PLoS One. 2019 Feb 4;14(2):e0208399. doi: 10.1371/journal.pone.0208399. eCollection 2019. PLoS One. 2019. PMID: 30716067 Free PMC article.
Diabetic retinopathy (DR) is a common neurovascular complication of type 1 diabetes. Current therapeutics target neovascularization characteristic of end-stage disease, but are associated with significant adverse effects. ...Here we reveal that activation of PPARalpha had …
Diabetic retinopathy (DR) is a common neurovascular complication of type 1 diabetes. Current therapeutics target neovascularization c …
Quasi-quantized Hall response in bulk InAs.
Wawrzyńczak R, Galeski S, Noky J, Sun Y, Felser C, Gooth J. Wawrzyńczak R, et al. Sci Rep. 2022 Feb 9;12(1):2153. doi: 10.1038/s41598-022-05916-2. Sci Rep. 2022. PMID: 35140258 Free PMC article.
Here, we compare the observation of quasi-quantized plateau-like features in the Hall conductivity of the n-type bulk semiconductor InAs with the predictions for the 3D QQHE in presence of parabolic electron bands. ...
Here, we compare the observation of quasi-quantized plateau-like features in the Hall conductivity of the n-type bulk semiconductor I …
Cell Fate Maintenance and Reprogramming During the Oocyte-to-Embryo Transition.
Fassnacht C, Ciosk R. Fassnacht C, et al. Results Probl Cell Differ. 2017;59:269-286. doi: 10.1007/978-3-319-44820-6_10. Results Probl Cell Differ. 2017. PMID: 28247053 Review.
Different animal models have been used to decipher the regulation of EGA. These models are often biased for the specific type of regulation, which is why we discuss the models ranging from invertebrates to mammals. ...
Different animal models have been used to decipher the regulation of EGA. These models are often biased for the specific type of regu …
High-density lipoprotein (HDL) cholesterol - more complicated than we think?
Nessler K, Windak A, Grzybczak R, Nessler MB, Siniarski A, Gajos G. Nessler K, et al. Ann Agric Environ Med. 2018 Sep 25;25(3):517-526. doi: 10.26444/aaem/92350. Epub 2018 Jul 12. Ann Agric Environ Med. 2018. PMID: 30260180 Free article. Review.
This study presents some possible directions for future research to bring us closer to the full understanding of the HDL particle and its role in patients with ischemic heart disease and type 2 diabetes....
This study presents some possible directions for future research to bring us closer to the full understanding of the HDL particle and its ro …
68 results