SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes.
Wang L, Huang J, Moore DC, Zuo C, Wu Q, Xie L, von der Mark K, Yuan X, Chen D, Warman ML, Ehrlich MG, Yang W.
Wang L, et al.
Sci Rep. 2017 Oct 5;7(1):12699. doi: 10.1038/s41598-017-12767-9.
Sci Rep. 2017.
PMID: 28983104
Free PMC article.
Transdifferentiation of hypertrophic chondrocytes into bone-forming osteoblasts has been reported, yet the underlying molecular mechanism remains incompletely understood. ...Elevated and sustained SOX9 in SHP2-deficient hypertrophic chondrocytes impaired their differentiat …
Transdifferentiation of hypertrophic chondrocytes into bone-forming osteoblasts has been reported, yet the underlying molecular mecha …