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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1999 1
2000 1
2002 2
2003 2
2004 5
2005 1
2007 1
2009 1
2010 4
2011 5
2012 1
2013 1
2014 5
2015 3
2017 1
2020 1
2021 1
2024 0

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32 results

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Page 1
Total syntheses of (-)-fructigenine A and (-)-5-N-acetylardeemin.
Takiguchi S, Iizuka T, Kumakura YS, Murasaki K, Ban N, Higuchi K, Kawasaki T. Takiguchi S, et al. J Org Chem. 2010 Feb 19;75(4):1126-31. doi: 10.1021/jo9023107. J Org Chem. 2010. PMID: 20073509
The key steps include highly enantioselective preparation of (+)-3 via domino olefination/isomerization/Claisen rearrangement (OIC) of 5, reductive cyclization (RC), and regioselective oxidation of (-)-4 and a novel assembly of the pyrazino ring of these alkaloids via Ugi three-c …
The key steps include highly enantioselective preparation of (+)-3 via domino olefination/isomerization/Claisen rearrangement (OIC) of 5, re …
4-Aminoquinolines: novel nociceptin antagonists with analgesic activity.
Shinkai H, Ito T, Iida T, Kitao Y, Yamada H, Uchida I. Shinkai H, et al. J Med Chem. 2000 Nov 30;43(24):4667-77. doi: 10.1021/jm0002073. J Med Chem. 2000. PMID: 11101358
Elucidation of structure-activity relationships eventually led to the optimum compounds. One of these compounds, N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide hydrochloride (11) not only antagonized nociceptin-induced allodynia in mice but also showed …
Elucidation of structure-activity relationships eventually led to the optimum compounds. One of these compounds, N-(4-amino-2-methylq …
Pharmacological characterization of diethyl-2-({3-dimethylcarbamoyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an intestine-specific inhibitor of microsomal triglyceride transfer protein.
Mera Y, Odani N, Kawai T, Hata T, Suzuki M, Hagiwara A, Katsushima T, Kakutani M. Mera Y, et al. J Pharmacol Exp Ther. 2011 Feb;336(2):321-7. doi: 10.1124/jpet.110.173807. Epub 2010 Oct 25. J Pharmacol Exp Ther. 2011. PMID: 20974698
To develop a specific inhibitor of intestinal MTP, JTT-130 [diethyl-2-({3-dimethylcarbamoyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate], was designed to be rapidly hydrolyzed in the absorption process. ...
To develop a specific inhibitor of intestinal MTP, JTT-130 [diethyl-2-({3-dimethylcarbamoyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)ami …
Molecular phylogenetic analyses support the monophyly of Hexapoda and suggest the paraphyly of Entognatha.
Sasaki G, Ishiwata K, Machida R, Miyata T, Su ZH. Sasaki G, et al. BMC Evol Biol. 2013 Oct 31;13:236. doi: 10.1186/1471-2148-13-236. BMC Evol Biol. 2013. PMID: 24176097 Free PMC article.
RESULTS: Phylogenetic analyses were conducted based on the inferred amino acid (aa) sequences (~3400 aa in total) of the three genes using the maximum likelihood (ML) method and Bayesian inference. ...
RESULTS: Phylogenetic analyses were conducted based on the inferred amino acid (aa) sequences (~3400 aa in total) of the three genes …
New class of corticotropin-releasing factor (CRF) antagonists: small peptides having high binding affinity for CRF receptor.
Yamada Y, Mizutani K, Mizusawa Y, Hantani Y, Tanaka M, Tanaka Y, Tomimoto M, Sugawara M, Imai N, Yamada H, Okajima N, Haruta J. Yamada Y, et al. J Med Chem. 2004 Feb 26;47(5):1075-8. doi: 10.1021/jm034180+. J Med Chem. 2004. PMID: 14971886
The discovery of small and potent peptide antagonists of the corticotropin-releasing factor (CRF) receptor is described. Through the structure-activity relationship studies of 12-amino acid peptide corresponding to the C-terminal residues of astressin, we assumed that a pa …
The discovery of small and potent peptide antagonists of the corticotropin-releasing factor (CRF) receptor is described. Through the structu …
Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease.
Murwantoko, Yano M, Ueta Y, Murasaki A, Kanda H, Oka C, Kawaichi M. Murwantoko, et al. Biochem J. 2004 Aug 1;381(Pt 3):895-904. doi: 10.1042/BJ20040435. Biochem J. 2004. PMID: 15101818 Free PMC article.
We searched for binding partners of the PDZ domain of mouse HtrA1 by yeast two-hybrid screening, and isolated proteins that were recognized by the HtrA1 PDZ domain through their C-terminal ends with a core consensus Phi-X-Phi-[V/L/F/A]-COOH sequence (where Phi is a hydrophobic/no …
We searched for binding partners of the PDZ domain of mouse HtrA1 by yeast two-hybrid screening, and isolated proteins that were recognized …
32 results