APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis.
Farmer BC, Williams HC, Devanney NA, Piron MA, Nation GK, Carter DJ, Walsh AE, Khanal R, Young LEA, Kluemper JC, Hernandez G, Allenger EJ, Mooney R, Golden LR, Smith CT, Brandon JA, Gupta VA, Kern PA, Gentry MS, Morganti JM, Sun RC, Johnson LA.
Farmer BC, et al.
Mol Neurodegener. 2021 Sep 6;16(1):62. doi: 10.1186/s13024-021-00483-y.
Mol Neurodegener. 2021.
PMID: 34488832
Free PMC article.
While this clinical feature has been described for over two decades, the mechanism underlying these changes in cerebral glucose metabolism remains a critical knowledge gap in the field. METHODS: Here, we undertook a multi-omic approach by combining single-cell RNA sequenci …
While this clinical feature has been described for over two decades, the mechanism underlying these changes in cerebral glucose metabolism r …