Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.
Loryan I, Reichel A, Feng B, Bundgaard C, Shaffer C, Kalvass C, Bednarczyk D, Morrison D, Lesuisse D, Hoppe E, Terstappen GC, Fischer H, Di L, Colclough N, Summerfield S, Buckley ST, Maurer TS, Fridén M.
Loryan I, et al.
Pharm Res. 2022 Jul;39(7):1321-1341. doi: 10.1007/s11095-022-03246-6. Epub 2022 Apr 11.
Pharm Res. 2022.
PMID: 35411506
Free PMC article.
PURPOSE: More than 15 years have passed since the first description of the unbound brain-to-plasma partition coefficient (K(p,uu,brain)) by Prof. Margareta Hammarlund-Udenaes, which was enabled by advancements in experimental methodologies including cerebral microdialysis. …
PURPOSE: More than 15 years have passed since the first description of the unbound brain-to-plasma partition coefficient (K(p,uu,brain)) by …