The failure of health care professionals and providers to recognize and discuss end-of-life care continues to resonate across our heath care continuum. The value of the patient-clinician interaction is paramount in advocating for and establishing effective communication and care. A meaningful nurse-patient relationship is a key component to facilitate discussion of patient and family choices in how care can be managed throughout the dying process. This article describes how, using Virginia Henderson's nursing model of patientcentered care, a holistic and palliative approach to end-of-life care was successfully supported in the home.