Post-surgical thyroid bed myofibroma simulating a recurrent papillary thyroid carcinoma: A case report and review of the literature

Medicine (Baltimore). 2024 Jan 12;103(2):e36945. doi: 10.1097/MD.0000000000036945.

Abstract

Rationale: Myofibromas are rare benign spindle cell tumors of the soft tissue, bone, or internal organs that occur at any age. Here, we report a post-surgical thyroid bed myofibroma that mimicked a papillary thyroid carcinoma.

Patient concerns: A 56-year-old male presented with a mass in the thyroid surgical bed, detected 3 years post thyroidectomy following papillary carcinoma.

Diagnosis: Thyroid ultrasonography revealed a well-defined, lobulated, hypoechoic, solid nodule, with large rod-like echogenic foci in the thyroid surgical bed. The development of a postoperative suture granuloma was considered. However, ultrasonography performed 12 months later showed a marked increase in the lesion size. Two fine needle aspiration cytology yielded nondiagnostic results.

Intervention: Considering the possibility of local tumor recurrence, surgical resection was performed.

Outcome: The diagnosis of a myofibroma was confirmed, and no additional treatment was administered.

Lessons: It is challenging to differentiate lesions occurring on the thyroid surgical bed after surgery, from recurrent thyroid cancer. A lesion measuring 6 mm, with a degree of punctate echogenicity, suggests tumor recurrence. Moreover, myofibromas are extremely rare. This case highlights that it is advisable to perform a core needle biopsy in cases of nondiagnostic fine needle aspiration results.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Humans
  • Leiomyoma* / surgery
  • Male
  • Middle Aged
  • Myofibroma* / surgery
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery
  • Thyroid Cancer, Papillary / diagnosis
  • Thyroid Cancer, Papillary / surgery
  • Thyroid Neoplasms* / diagnosis
  • Thyroid Neoplasms* / pathology
  • Thyroid Neoplasms* / surgery
  • Thyroidectomy / methods