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Page 1
Formation of memory assemblies through the DNA-sensing TLR9 pathway.
Jovasevic V, Wood EM, Cicvaric A, Zhang H, Petrovic Z, Carboncino A, Parker KK, Bassett TE, Moltesen M, Yamawaki N, Login H, Kalucka J, Sananbenesi F, Zhang X, Fischer A, Radulovic J. Jovasevic V, et al. Nature. 2024 Apr;628(8006):145-153. doi: 10.1038/s41586-024-07220-7. Epub 2024 Mar 27. Nature. 2024. PMID: 38538785 Free PMC article.
Following these early events, some neurons acquired an inflammatory phenotype involving activation of TLR9 signalling and accumulation of centrosomal DNA damage repair complexes(6). Neuron-specific knockdown of Tlr9 impaired memory while blunting contextual fear conditioni …
Following these early events, some neurons acquired an inflammatory phenotype involving activation of TLR9 signalling and accumulation of ce …
Neonates undergoing pyloric stenosis repair are at increased risk of difficult airway management: secondary analysis of the NEonate and Children audiT of Anaesthesia pRactice IN Europe.
Disma N, Engelhardt T, Hansen TG, de Graaff JC, Virag K, Habre W; NECTARINE Group of the European Society of Anaesthesiology and Intensive; AUSTRIA (Maria Vittinghoff); BELGIUM (Francis Veyckemans); CROATIA (Sandra Kralik); CZECH REPUBLIC (Jiří Žurek); DENMARK (Tom Hansen); ESTONIA (Reet Kikas); FINLAND (Tuula Manner); FRANCE (Christophe Dadure, Anne Lafargue); GERMANY (Karin Becke, Claudia Hoehne); GREECE (Anna Malisiova); HUNGARY (Andrea Székely); IRELAND (Brendan O’Hare); ITALY (Nicola Disma); LATVIA (Zane Straume); LITHUANIA (Laura Lukosiene); LUXEMBOURG (Bernd Schmitz); MALTA (Francis Borg); NETHERLANDS (Jurgen de Graaff); NORWAY (Wenche B Boerke); POLAND (Marzena Zielinska); PORTUGAL (Maria Domingas Patuleia); ROMANIA (Radu Tabacaru); SERBIA (Dusica Simic); SLOVAKIA (Miloslav Hanula); SLOVENIA (Jelena Berger); SPAIN (Ignacio Gálvez Escalera); SWEDEN (Albert Castellheim); SWITZERLAND (Walid Habre); TURKEY (Dilek Özcengiz - Zehra Hatipoğlu); UKRAINE (Dmytro Dmytriiev); UNITED KINGDOM (Thomas Engelhardt, Suellen Walker); Management Team. Disma N, et al. Br J Anaesth. 2022 Nov;129(5):734-739. doi: 10.1016/j.bja.2022.07.041. Epub 2022 Sep 6. Br J Anaesth. 2022. PMID: 36085092 Free article. Clinical Trial.
The primary aim was to study whether or not the incidence of difficult airway management and of hypoxaemia in neonates undergoing pyloric stenosis repair was higher than that in neonates undergoing other surgeries. ...
The primary aim was to study whether or not the incidence of difficult airway management and of hypoxaemia in neonates undergoing pyloric st …
NOTCH1 modulates activity of DNA-PKcs.
Adamowicz M, d'Adda di Fagagna F, Vermezovic J. Adamowicz M, et al. Mutat Res. 2018 Mar;808:20-27. doi: 10.1016/j.mrfmmm.2018.01.003. Mutat Res. 2018. PMID: 29482073
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) controls one of the most frequently used DNA repair pathways in a cell, the non-homologous end joining (NHEJ) pathway. ...Surprisingly, NOTCH1-expressing cells do not display any significant impairment in the DNA da …
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) controls one of the most frequently used DNA repair pathways in a cell, the …
Transcriptional regulation of hepatic stellate cells.
Mann J, Mann DA. Mann J, et al. Adv Drug Deliv Rev. 2009 Jul 2;61(7-8):497-512. doi: 10.1016/j.addr.2009.03.011. Epub 2009 Apr 22. Adv Drug Deliv Rev. 2009. PMID: 19393271 Review.
Hepatic stellate cell (HSC) activation is a process of cellular transdifferentiation in which, upon liver injury, the quiescent vitamin A storing perisinusoidal HSC is converted into a wound-healing myofibroblast and acquires potent pro-inflammatory and pro-fibrogen …
Hepatic stellate cell (HSC) activation is a process of cellular transdifferentiation in which, upon liver injury, the quiescent vitamin A st …
Electric field-responsive nanoparticles and electric fields: physical, chemical, biological mechanisms and therapeutic prospects.
Kolosnjaj-Tabi J, Gibot L, Fourquaux I, Golzio M, Rols MP. Kolosnjaj-Tabi J, et al. Adv Drug Deliv Rev. 2019 Jan 1;138:56-67. doi: 10.1016/j.addr.2018.10.017. Epub 2018 Nov 7. Adv Drug Deliv Rev. 2019. PMID: 30414494 Review.
Occurring endogenously or exogenously, the electric field can be used as a trigger for controlled drug release from electroresponsive drug delivery systems, can stimulate wound healing and cell proliferation, may enhance endocytosis or guide stem cell differentiatio …
Occurring endogenously or exogenously, the electric field can be used as a trigger for controlled drug release from electroresponsive drug d …
Characterization of gross genome rearrangements in Deinococcus radiodurans recA mutants.
Repar J, Zahradka D, Sović I, Zahradka K. Repar J, et al. Sci Rep. 2021 May 25;11(1):10939. doi: 10.1038/s41598-021-89173-9. Sci Rep. 2021. PMID: 34035321 Free PMC article.
Genome stability in radioresistant bacterium Deinococcus radiodurans depends on RecA, the main bacterial recombinase. Without RecA, gross genome rearrangements occur during repair of DNA double-strand breaks. Long repeated (insertion) sequences have been identified as hot …
Genome stability in radioresistant bacterium Deinococcus radiodurans depends on RecA, the main bacterial recombinase. Without RecA, gross ge …
Pseudevernia furfuracea inhibits migration and invasion of colorectal carcinoma cell lines.
Šeklić DS, Jovanović MM, Virijević KD, Grujić JN, Živanović MN, Marković SD. Šeklić DS, et al. J Ethnopharmacol. 2022 Feb 10;284:114758. doi: 10.1016/j.jep.2021.114758. Epub 2021 Oct 21. J Ethnopharmacol. 2022. PMID: 34688797
MATERIALS AND METHODS: Collective cell migration was assessed by Wound healing assay and single cell migration in real time by RTCA method. ...
MATERIALS AND METHODS: Collective cell migration was assessed by Wound healing assay and single cell migration in real time by …
High-Throughput Genotyping of CRISPR/Cas Edited Cells in 96-Well Plates.
Nussbaum L, Telenius JM, Hill S, Hirschfeld PP, Suciu MC; WIGWAM Consortium; Downes DJ, Hughes JR. Nussbaum L, et al. Methods Protoc. 2018 Aug 1;1(3):29. doi: 10.3390/mps1030029. Methods Protoc. 2018. PMID: 31164571 Free PMC article.
The emergence in recent years of DNA editing technologies-Zinc finger nucleases (ZFNs), transcription activator-like effector (TALE) guided nucleases (TALENs), clustered regularly interspaced short palindromic repeats (CRISPR)/Cas family enzymes, and Base-Editors-have greatly inc …
The emergence in recent years of DNA editing technologies-Zinc finger nucleases (ZFNs), transcription activator-like effector (TALE) guided …
Elevated Rate of Genome Rearrangements in Radiation-Resistant Bacteria.
Repar J, Supek F, Klanjscek T, Warnecke T, Zahradka K, Zahradka D. Repar J, et al. Genetics. 2017 Apr;205(4):1677-1689. doi: 10.1534/genetics.116.196154. Epub 2017 Feb 10. Genetics. 2017. PMID: 28188144 Free PMC article.
One of the challenges these species face is a potent environmental source of DNA double-strand breaks, potential drivers of genome structure evolution. Efficient and accurate DNA double-strand break repair systems have been demonstrated in several unrelated radiation-resis …
One of the challenges these species face is a potent environmental source of DNA double-strand breaks, potential drivers of genome structure …
Macrophages' contribution to ectopic osteogenesis in combination with blood clot and bone substitute: possibility for application in bone regeneration strategies.
Živković JM, Stojanović ST, Vukelić-Nikolić MĐ, Radenković MB, Najdanović JG, Ćirić M, Najman SJ. Živković JM, et al. Int Orthop. 2021 Apr;45(4):1087-1095. doi: 10.1007/s00264-020-04826-0. Epub 2020 Oct 6. Int Orthop. 2021. PMID: 33025084
PURPOSE: Given the great potential of macrophages in the processes of tissue repair and regeneration, the aim of our study was to examine the contribution that macrophages will have in osteogenic process when combined and implanted with blood clot (BC) and mineral bone sub …
PURPOSE: Given the great potential of macrophages in the processes of tissue repair and regeneration, the aim of our study was to exa …
16 results