Formation of memory assemblies through the DNA-sensing TLR9 pathway.
Jovasevic V, Wood EM, Cicvaric A, Zhang H, Petrovic Z, Carboncino A, Parker KK, Bassett TE, Moltesen M, Yamawaki N, Login H, Kalucka J, Sananbenesi F, Zhang X, Fischer A, Radulovic J.
Jovasevic V, et al.
Nature. 2024 Apr;628(8006):145-153. doi: 10.1038/s41586-024-07220-7. Epub 2024 Mar 27.
Nature. 2024.
PMID: 38538785
Free PMC article.
Following these early events, some neurons acquired an inflammatory phenotype involving activation of TLR9 signalling and accumulation of centrosomal DNA damage repair complexes(6). Neuron-specific knockdown of Tlr9 impaired memory while blunting contextual fear conditioni …
Following these early events, some neurons acquired an inflammatory phenotype involving activation of TLR9 signalling and accumulation of ce …