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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1922 2
1923 41
1924 48
1925 23
1926 26
1927 33
1928 14
1929 13
1930 12
1931 13
1932 13
1933 16
1934 13
1935 13
1936 21
1937 18
1938 34
1939 22
1940 17
1941 14
1942 16
1943 10
1944 10
1945 37
1946 116
1947 152
1948 172
1949 165
1950 246
1951 293
1952 314
1953 352
1954 401
1955 317
1956 348
1957 314
1958 337
1959 362
1960 325
1961 368
1962 404
1963 734
1964 999
1965 788
1966 1030
1967 1224
1968 1634
1969 1777
1970 1876
1971 2062
1972 2209
1973 2223
1974 2365
1975 2430
1976 2615
1977 2538
1978 2709
1979 3090
1980 3418
1981 3577
1982 3836
1983 4158
1984 4499
1985 4594
1986 4727
1987 4880
1988 5381
1989 5845
1990 6083
1991 6473
1992 6543
1993 6886
1994 7105
1995 7282
1996 7563
1997 7994
1998 7789
1999 7852
2000 8081
2001 8303
2002 8909
2003 9357
2004 10521
2005 11462
2006 12326
2007 13107
2008 14063
2009 14661
2010 15472
2011 16076
2012 16869
2013 18000
2014 18066
2015 18221
2016 18004
2017 18021
2018 18153
2019 18023
2020 19526
2021 20023
2022 19119
2023 17607
2024 8184
2025 1

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482,098 results

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Page 1
Insulin structure and function.
Mayer JP, Zhang F, DiMarchi RD. Mayer JP, et al. Biopolymers. 2007;88(5):687-713. doi: 10.1002/bip.20734. Biopolymers. 2007. PMID: 17410596 Review.
How the structural and conformational dynamics of this endocrine hormone elicit its biological response remains a vigorous area of study. Numerous insulin analogs have served to coordinate structural biology and biochemical signaling to provide a first level understanding …
How the structural and conformational dynamics of this endocrine hormone elicit its biological response remains a vigorous area of study. Nu …
Basal insulin: physiology, pharmacology, and clinical implications.
Niswender KD. Niswender KD. Postgrad Med. 2011 Jul;123(4):17-26. doi: 10.3810/pgm.2011.07.2300. Postgrad Med. 2011. PMID: 21680985 Review.
This will be accomplished within a broader contextual discussion of the normal physiologic patterns of insulin secretion, which consist of sustained levels of basal insulin production throughout the day, superimposed with bursts of insulin secretion following …
This will be accomplished within a broader contextual discussion of the normal physiologic patterns of insulin secretion, which consi …
The discovery of insulin revisited: lessons for the modern era.
Lewis GF, Brubaker PL. Lewis GF, et al. J Clin Invest. 2021 Jan 4;131(1):e142239. doi: 10.1172/JCI142239. J Clin Invest. 2021. PMID: 33393501 Free PMC article. Review.
2021 to 2022 marks the one hundredth anniversary of ground-breaking research in Toronto that changed the course of what was, then, a universally fatal disease: type 1 diabetes. Some would argue that insulin's discovery by Banting, Best, Macleod, and Collip was the g …
2021 to 2022 marks the one hundredth anniversary of ground-breaking research in Toronto that changed the course of what was, then, a univers …
Insulin.
Thevis M, Thomas A, Schänzer W. Thevis M, et al. Handb Exp Pharmacol. 2010;(195):209-26. doi: 10.1007/978-3-540-79088-4_10. Handb Exp Pharmacol. 2010. PMID: 20020367 Review.
Various reports described the misuse of insulin to improve performance and muscle strength, and synthetic analogs were the subject of several studies describing the beneficial effects of biotechnologically modified insulins. Rapid- or long-acting insulins wer …
Various reports described the misuse of insulin to improve performance and muscle strength, and synthetic analogs were the subject of …
Insulin therapy.
Greco DS, Broussard JD, Peterson ME. Greco DS, et al. Vet Clin North Am Small Anim Pract. 1995 May;25(3):677-89. doi: 10.1016/s0195-5616(95)50062-2. Vet Clin North Am Small Anim Pract. 1995. PMID: 7660541 Review.
Since the discovery of insulin in 1921, a variety of insulin formulations have been developed. The purpose of this article is to describe the current sources, formulations, and types of insulins available for therapy of diabetes mellitus in small animals and …
Since the discovery of insulin in 1921, a variety of insulin formulations have been developed. The purpose of this article is …
Insulin analogues in type 1 diabetes mellitus: getting better all the time.
Mathieu C, Gillard P, Benhalima K. Mathieu C, et al. Nat Rev Endocrinol. 2017 Jul;13(7):385-399. doi: 10.1038/nrendo.2017.39. Epub 2017 Apr 21. Nat Rev Endocrinol. 2017. PMID: 28429780 Review.
This approach means that glucose sensing needs to be replaced and levels of insulin need to mimic physiological insulin-action profiles, including basal coverage and changes around meals. ...Insulin analogues enable patients to achieve this goal, as some have …
This approach means that glucose sensing needs to be replaced and levels of insulin need to mimic physiological insulin-action …
New Horizons: Next-Generation Insulin Analogues: Structural Principles and Clinical Goals.
Jarosinski MA, Chen YS, Varas N, Dhayalan B, Chatterjee D, Weiss MA. Jarosinski MA, et al. J Clin Endocrinol Metab. 2022 Mar 24;107(4):909-928. doi: 10.1210/clinem/dgab849. J Clin Endocrinol Metab. 2022. PMID: 34850005 Free PMC article. Review.
Design of "first-generation" insulin analogues over the past 3 decades has provided pharmaceutical formulations with tailored pharmacokinetic (PK) and pharmacodynamic (PD) properties. ...Smart insulin analogues and delivery systems promise to mitigate hypoglycemic r …
Design of "first-generation" insulin analogues over the past 3 decades has provided pharmaceutical formulations with tailored pharmac …
The future of insulin therapy.
Heise T. Heise T. Diabetes Res Clin Pract. 2021 May;175:108820. doi: 10.1016/j.diabres.2021.108820. Epub 2021 Apr 16. Diabetes Res Clin Pract. 2021. PMID: 33865915
This review summarises the available clinical data for some ongoing developments of new insulins and evaluates their potential for future insulin therapy. Once-weekly insulins will most likely be the next addition to the insulin armamentarium. ...
This review summarises the available clinical data for some ongoing developments of new insulins and evaluates their potential for fu …
The evolution of insulin therapy.
Home P. Home P. Diabetes Res Clin Pract. 2021 May;175:108816. doi: 10.1016/j.diabres.2021.108816. Epub 2021 Apr 20. Diabetes Res Clin Pract. 2021. PMID: 33862058
The nature of insulin was established serially, in 1928 as a polypeptide, in 1955 by amino acid sequence, and later by 3-dimensional structure (1969), laying foundations for understandings on routes of administration, and later the engineering of novel insulins. ... …
The nature of insulin was established serially, in 1928 as a polypeptide, in 1955 by amino acid sequence, and later by 3-dimensional …
A Century of Progress in Diabetes Care with Insulin: A History of Innovations and Foundation for the Future.
Lee SH, Yoon KH. Lee SH, et al. Diabetes Metab J. 2021 Sep;45(5):629-640. doi: 10.4093/dmj.2021.0163. Epub 2021 Sep 30. Diabetes Metab J. 2021. PMID: 34610718 Free PMC article. Review.
Since the 1980s, recombinant DNA technology has been employed to engineer insulin analogs by modifying their amino acid sequence, which has resulted in the production of insulins with various profiles that are currently used. However, unmet needs in insulin t …
Since the 1980s, recombinant DNA technology has been employed to engineer insulin analogs by modifying their amino acid sequence, whi …
482,098 results
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Searches related to "insulin"