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1963 1
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18 results

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Page 1
Immune Privilege and Eye-Derived T-Regulatory Cells.
Keino H, Horie S, Sugita S. Keino H, et al. J Immunol Res. 2018 May 20;2018:1679197. doi: 10.1155/2018/1679197. eCollection 2018. J Immunol Res. 2018. PMID: 29888291 Free PMC article. Review.
In this review, we summarize current knowledge regarding the molecular mechanism responsible for the development and maintenance of ocular immune privilege via regulatory T cells (Tregs), which are generated by the anterior chamber-associated immune deviation (ACAID), and ocular …
In this review, we summarize current knowledge regarding the molecular mechanism responsible for the development and maintenance of ocular i …
Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1+ T helper 1 cells by a contact-dependent mechanism.
Sugita S, Usui Y, Horie S, Futagami Y, Yamada Y, Ma J, Kezuka T, Hamada H, Usui T, Mochizuki M, Yamagami S. Sugita S, et al. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):263-72. doi: 10.1167/iovs.08-2536. Epub 2008 Sep 4. Invest Ophthalmol Vis Sci. 2009. PMID: 18775867
PURPOSE: This study was designed to determine whether human corneal endothelial (HCE) cells could regulate the activation of bystander T cells in vitro. ...HCE efficiently inhibited the proliferation of Th1 cells that overexpressed PD-1 among various activated T-cell lines …
PURPOSE: This study was designed to determine whether human corneal endothelial (HCE) cells could regulate the activation of bystande …
The effect of sodium hyaluronate on the growth of rabbit corneal epithelial cells in vitro.
Miyazaki T, Miyauchi S, Nakamura T, Takeshita S, Horie K. Miyazaki T, et al. J Ocul Pharmacol Ther. 1996 Winter;12(4):409-15. doi: 10.1089/jop.1996.12.409. J Ocul Pharmacol Ther. 1996. PMID: 8951677
The effect of sodium hyaluronate (Na-HA) on the growth of rabbit corneal epithelial cells was investigated in vitro by using MTT assay and [3H]-thymidine incorporation. ...These results suggest that Na-HA binds to the CD44-like molecule associated with FN and then enhances …
The effect of sodium hyaluronate (Na-HA) on the growth of rabbit corneal epithelial cells was investigated in vitro by using MTT assa …
Induction of T regulatory cells by cytotoxic T-lymphocyte antigen-2alpha on corneal endothelial cells.
Sugita S, Yamada Y, Horie S, Nakamura O, Ishidoh K, Yamamoto Y, Yamagami S, Mochizuki M. Sugita S, et al. Invest Ophthalmol Vis Sci. 2011 Apr 20;52(5):2598-605. doi: 10.1167/iovs.10-6322. Invest Ophthalmol Vis Sci. 2011. PMID: 21245393
PURPOSE: To determine whether murine corneal endothelial (CE) cells can promote the generation of T regulatory (Treg) cells in vitro. ...
PURPOSE: To determine whether murine corneal endothelial (CE) cells can promote the generation of T regulatory (Treg) cells in vitro. …
Protective efficacy of sodium hyaluronate on the corneal endothelium against the damage induced by sonication.
Miyauchi S, Horie K, Morita M, Nagahara M, Shimizu K. Miyauchi S, et al. J Ocul Pharmacol Ther. 1996 Spring;12(1):27-34. doi: 10.1089/jop.1996.12.27. J Ocul Pharmacol Ther. 1996. PMID: 8925393
The protective efficacy of sodium hyaluronate (Na-HA) on the corneal endothelium against the damage induced by sonication was investigated using enucleated rabbit eyes and Na-HA fluorescence labeled with 5-aminofluorescein (FA-HA). ...The protective efficacy was evaluated …
The protective efficacy of sodium hyaluronate (Na-HA) on the corneal endothelium against the damage induced by sonication was investi …
Inhibitory effect of corneal endothelial cells on IL-17-producing Th17 cells.
Sugita S, Kawazoe Y, Yamada Y, Imai A, Horie S, Yamagami S, Mochizuki M. Sugita S, et al. Br J Ophthalmol. 2012 Feb;96(2):293-9. doi: 10.1136/bjophthalmol-2011-300769. Epub 2011 Nov 17. Br J Ophthalmol. 2012. PMID: 22096139
AIM: To determine whether cultured corneal endothelial (CE) cells suppress interleukin 17 (IL-17)-producing effector T cells in vitro. ...CONCLUSION: CE cells impair the effector functions and activation of IL-17-producing helper T cells in a cell-contact-dependent mechani …
AIM: To determine whether cultured corneal endothelial (CE) cells suppress interleukin 17 (IL-17)-producing effector T cells in vitro …
[Functions of the transforming growth factor-beta superfamily in eyes].
Yamashita H, Tobari I, Sawa M, Hori S, Miyazono K, Heldin CH, Heldin P, Dijke PT, Sampath TK, Suiryu T, Eguchi S, Kitano S, Suzuki S, Ichijo H, Kato M, Yamamoto T, Funazu E, Suzuki M, Ikegami Y, Kato S, Obata H, Horie K, Mogi Y, Seiya K, Sakai H, et al. Yamashita H, et al. Nippon Ganka Gakkai Zasshi. 1997 Dec;101(12):927-47. Nippon Ganka Gakkai Zasshi. 1997. PMID: 9436357 Review. Japanese.
TGF-beta family members and the TGF-beta superfamily receptor family are expressed in ocular tissues including the cornea, ciliary epithelium, lens epithelium, retina, and blood vessels. ...TGF-beta is involved in the formation of abnormal connective tissue in corneal …
TGF-beta family members and the TGF-beta superfamily receptor family are expressed in ocular tissues including the cornea, ciliary ep …
Hyaluronan and chondroitin sulfate in rabbit tears.
Miyauchi S, Morita M, Kuramoto K, Horie K. Miyauchi S, et al. Curr Eye Res. 1996 Feb;15(2):131-5. doi: 10.3109/02713689608997405. Curr Eye Res. 1996. PMID: 8670720
The concentrations of hyaluronan (HA) and chondroitin sulfate (CS) in rabbit tears were determined using high performance liquid chromatography. The tears were taken from both normal eyes and eyes with a corneal epithelial defect. The concentration of CS was 7.61 times hig …
The concentrations of hyaluronan (HA) and chondroitin sulfate (CS) in rabbit tears were determined using high performance liquid chromatogra …
Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice.
Lennikov A, Kitaichi N, Kase S, Noda K, Horie Y, Nakai A, Ohno S, Ishida S. Lennikov A, et al. Int J Mol Sci. 2013 Jan 22;14(1):2175-89. doi: 10.3390/ijms14012175. Int J Mol Sci. 2013. PMID: 23340653 Free PMC article.

Significantly fewer TUNEL-positive cells were observed in the eyes of GGA-treated mice than controls after irradiation (p < 0.01). Corneal HSP70 levels were significantly elevated in corneas of mice treated with GGA (p < 0.05). ...GGA-treatment induced HSP70 expressi

…

Significantly fewer TUNEL-positive cells were observed in the eyes of GGA-treated mice than controls after irradiation (p < 0.01). Cor

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Mechanisms of immune suppression for CD8+ T cells by human corneal endothelial cells via membrane-bound TGFbeta.
Yamada Y, Sugita S, Horie S, Yamagami S, Mochizuki M. Yamada Y, et al. Invest Ophthalmol Vis Sci. 2010 May;51(5):2548-57. doi: 10.1167/iovs.09-4233. Epub 2009 Dec 10. Invest Ophthalmol Vis Sci. 2010. PMID: 20007827
PURPOSE: To determine whether CD8(+) T cells in vitro are suppressed or converted into regulators (Treg cells) by human corneal endothelial (HCE) cells. METHODS: HCE cell lines were established from primary HCE cells, and allogeneic CD8(+) T cells were isolated from periph …
PURPOSE: To determine whether CD8(+) T cells in vitro are suppressed or converted into regulators (Treg cells) by human corneal endot …
18 results