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1985 1
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2004 7
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226 results

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Page 1
Showing results for hampered simon
Search for hemperek simon instead (1 results)
Menstruation: science and society.
Critchley HOD, Babayev E, Bulun SE, Clark S, Garcia-Grau I, Gregersen PK, Kilcoyne A, Kim JJ, Lavender M, Marsh EE, Matteson KA, Maybin JA, Metz CN, Moreno I, Silk K, Sommer M, Simon C, Tariyal R, Taylor HS, Wagner GP, Griffith LG. Critchley HOD, et al. Am J Obstet Gynecol. 2020 Nov;223(5):624-664. doi: 10.1016/j.ajog.2020.06.004. Epub 2020 Jul 21. Am J Obstet Gynecol. 2020. PMID: 32707266 Free PMC article. Review.
Women's health concerns are generally underrepresented in basic and translational research, but reproductive health in particular has been hampered by a lack of understanding of basic uterine and menstrual physiology. ...
Women's health concerns are generally underrepresented in basic and translational research, but reproductive health in particular has been …
Inflammatory breast cancer defined: proposed common diagnostic criteria to guide treatment and research.
Jagsi R, Mason G, Overmoyer BA, Woodward WA, Badve S, Schneider RJ, Lang JE, Alpaugh M, Williams KP, Vaught D, Smith A, Smith K, Miller KD; Susan G. Komen-IBCRF IBC Collaborative in partnership with the Milburn Foundation. Jagsi R, et al. Breast Cancer Res Treat. 2022 Apr;192(2):235-243. doi: 10.1007/s10549-021-06434-x. Epub 2022 Jan 1. Breast Cancer Res Treat. 2022. PMID: 34973083 Free PMC article. Review.
A key challenge relates to the need for a more detailed, formal, objective definition of IBC, the lack of which compromises clinical care, hampers the conduct of clinical trials, and hinders the search for IBC-specific biomarkers and treatments because of the heterogeneity …
A key challenge relates to the need for a more detailed, formal, objective definition of IBC, the lack of which compromises clinical care, …
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.
Santos-Zas I, Lemarié J, Zlatanova I, Cachanado M, Seghezzi JC, Benamer H, Goube P, Vandestienne M, Cohen R, Ezzo M, Duval V, Zhang Y, Su JB, Bizé A, Sambin L, Bonnin P, Branchereau M, Heymes C, Tanchot C, Vilar J, Delacroix C, Hulot JS, Cochain C, Bruneval P, Danchin N, Tedgui A, Mallat Z, Simon T, Ghaleh B, Silvestre JS, Ait-Oufella H. Santos-Zas I, et al. Nat Commun. 2021 Mar 5;12(1):1483. doi: 10.1038/s41467-021-21737-9. Nat Commun. 2021. PMID: 33674611 Free PMC article.
Depletion of CD8(+) T lymphocytes decreases apoptosis within the ischemic myocardium, hampers inflammatory response, limits myocardial injury and improves heart function. ...
Depletion of CD8(+) T lymphocytes decreases apoptosis within the ischemic myocardium, hampers inflammatory response, limits myocardia …
Neurophysiology of Human Perceptual Decision-Making.
O'Connell RG, Kelly SP. O'Connell RG, et al. Annu Rev Neurosci. 2021 Jul 8;44:495-516. doi: 10.1146/annurev-neuro-092019-100200. Epub 2021 May 4. Annu Rev Neurosci. 2021. PMID: 33945693 Review.
For a long time, such signals were only accessible through direct animal brain recordings, and progress in human neuroscience was hampered by the limitations of noninvasive recording techniques. However, recent methodological advances are increasingly enabling the study of …
For a long time, such signals were only accessible through direct animal brain recordings, and progress in human neuroscience was hampere …
Human liver organoids for disease modeling of fibrolamellar carcinoma.
Narayan NJC, Requena D, Lalazar G, Ramos-Espiritu L, Ng D, Levin S, Shebl B, Wang R, Hammond WJ, Saltsman JA 3rd, Gehart H, Torbenson MS, Clevers H, LaQuaglia MP, Simon SM. Narayan NJC, et al. Stem Cell Reports. 2022 Aug 9;17(8):1874-1888. doi: 10.1016/j.stemcr.2022.06.003. Epub 2022 Jul 7. Stem Cell Reports. 2022. PMID: 35803261 Free PMC article.
Fibrolamellar carcinoma (FLC) is a rare, often lethal, liver cancer affecting adolescents and young adults, for which there are no approved therapeutics. The development of therapeutics is hampered by a lack of in vitro models. Organoids have shown utility as a model syste …
Fibrolamellar carcinoma (FLC) is a rare, often lethal, liver cancer affecting adolescents and young adults, for which there are no approved …
Targeting BCL-XL in fibrolamellar hepatocellular carcinoma.
Shebl B, Ng D, Lalazar G, Rosemore C, Finkelstein TM, Migler RD, Zheng G, Zhang P, Jiang CS, Qureshi A, Vaughan R, Yarchoan M, de Jong YP, Rice CM, Coffino P, Ortiz MV, Zhou D, Simon SM. Shebl B, et al. JCI Insight. 2022 Sep 8;7(17):e161820. doi: 10.1172/jci.insight.161820. JCI Insight. 2022. PMID: 36073545 Free PMC article.
As BCL-XL is physiologically expressed in platelets, prior efforts to leverage this vulnerability in other cancers have been hampered by severe thrombocytopenia. To overcome this toxicity, we treated FLC models with DT2216, a proteolysis targeting chimera (PROTAC) that dir …
As BCL-XL is physiologically expressed in platelets, prior efforts to leverage this vulnerability in other cancers have been hampered …
Change detection evokes a Simon-like effect.
Galfano G, Mazza V, Tamè L, Umiltà C, Turatto M. Galfano G, et al. Acta Psychol (Amst). 2008 Jan;127(1):186-96. doi: 10.1016/j.actpsy.2007.04.004. Epub 2007 Jun 14. Acta Psychol (Amst). 2008. PMID: 17573027
By contrast, no Simon-like effect was observed under conditions of change blindness, namely when attention shifting towards the change location was hampered. ...Overall, our findings show that a Simon-like effect can only be observed under conditions of expli …
By contrast, no Simon-like effect was observed under conditions of change blindness, namely when attention shifting towards the chang …
Repeated implantation failure: clinical approach.
Simon A, Laufer N. Simon A, et al. Fertil Steril. 2012 May;97(5):1039-43. doi: 10.1016/j.fertnstert.2012.03.010. Epub 2012 Mar 30. Fertil Steril. 2012. PMID: 22464086 Free article. Review.
Successful embryo implantation depends on a well-functioning endometrium as well as a normal healthy embryo. This process might be hampered if either of these variables is defective. Repeated implantation failure (RIF) is diagnosed when good-quality embryos repeatedly fail …
Successful embryo implantation depends on a well-functioning endometrium as well as a normal healthy embryo. This process might be hamper …
Ustekinumab for the treatment of Crohn's disease: can it find its niche?
Simon EG, Ghosh S, Iacucci M, Moran GW. Simon EG, et al. Therap Adv Gastroenterol. 2016 Jan;9(1):26-36. doi: 10.1177/1756283X15618130. Therap Adv Gastroenterol. 2016. PMID: 26770265 Free PMC article. Review.
The past two decades have witnessed the emergence of an important class of drugs known as anti-tumour necrosis factor (TNF) agents in the treatment of Crohn's disease. Unfortunately, the utility of these agents have been hampered by primary and secondary nonresponse in a s …
The past two decades have witnessed the emergence of an important class of drugs known as anti-tumour necrosis factor (TNF) agents in the tr …
A weakly structured stem for human origins in Africa.
Ragsdale AP, Weaver TD, Atkinson EG, Hoal EG, Möller M, Henn BM, Gravel S. Ragsdale AP, et al. Nature. 2023 May;617(7962):755-763. doi: 10.1038/s41586-023-06055-y. Epub 2023 May 17. Nature. 2023. PMID: 37198480 Free PMC article.
Despite broad agreement that Homo sapiens originated in Africa, considerable uncertainty surrounds specific models of divergence and migration across the continent(1). Progress is hampered by a shortage of fossil and genomic data, as well as variability in previous estimat …
Despite broad agreement that Homo sapiens originated in Africa, considerable uncertainty surrounds specific models of divergence and migrati …
226 results