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Daurisoline Inhibiting Tumor Angiogenesis and Epithelial-Mesenchymal Transition in Bladder Cancer by Mediating HAKAI Protein Stability.
Huang K, Chen Q, Deng L, Zou Q, Min S. Huang K, et al. Iran J Pharm Res. 2022 Dec 3;21(1):e129798. doi: 10.5812/ijpr-129798. eCollection 2022 Dec. Iran J Pharm Res. 2022. PMID: 36937208 Free PMC article.
METHODS: Tissue samples were taken from 40 patients with bladder cancer to analyze the expression of HAKAI and the relationship between HAKAI expression and patient survival. ...HAKAI could target E-cad. Daurisoline also counteracted the promotive effects of …
METHODS: Tissue samples were taken from 40 patients with bladder cancer to analyze the expression of HAKAI and the relationship betwe …
Ethoxysanguinarine Induces Apoptosis, Inhibits Metastasis and Sensitizes cells to Docetaxel in Breast Cancer Cells through Inhibition of Hakai.
Ma L, Xuan XJ, Chen XM, Fan MH, Liu J, Huang GZ, Liu Z. Ma L, et al. Chem Biodivers. 2023 Feb;20(2):e202200284. doi: 10.1002/cbdv.202200284. Epub 2023 Jan 23. Chem Biodivers. 2023. PMID: 36633334
ESG attenuated breast cancer cell migration and invasion through Hakai/E-cadherin/N-cadherin. Moreover, Hakai knockdown sensitized ESG-triggered viability and motility inhibition, suggesting that Hakai mediated the anti-breast cancer effect of ESG. ...Overall …
ESG attenuated breast cancer cell migration and invasion through Hakai/E-cadherin/N-cadherin. Moreover, Hakai knockdown sensit …
Forecasting parasite sharing under climate change.
Morales-Castilla I, Pappalardo P, Farrell MJ, Aguirre AA, Huang S, Gehman AM, Dallas T, Gravel D, Davies TJ. Morales-Castilla I, et al. Philos Trans R Soc Lond B Biol Sci. 2021 Nov 8;376(1837):20200360. doi: 10.1098/rstb.2020.0360. Epub 2021 Sep 20. Philos Trans R Soc Lond B Biol Sci. 2021. PMID: 34538143 Free PMC article.
Celastrol inhibits the migration and invasion and enhances the anti-cancer effects of docetaxel in human triple-negative breast cancer cells.
Liu Z, Fan M, Xuan X, Xia C, Huang G, Ma L. Liu Z, et al. Med Oncol. 2022 Sep 7;39(12):189. doi: 10.1007/s12032-022-01792-y. Med Oncol. 2022. PMID: 36071249
Molecular data showed that the effect of celastrol on TNBC cells might be mediated via up-regulation of E-cadherin, a key protein involved in epithelial-mesenchymal transition (EMT). In addition, Hakai, an E3 ligase responsible for E-cadherin complex ubiquitination and deg …
Molecular data showed that the effect of celastrol on TNBC cells might be mediated via up-regulation of E-cadherin, a key protein involved i …
An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin.
Chen Y, Chen CH, Tung PY, Huang SH, Wang SM. Chen Y, et al. J Cell Biochem. 2009 Nov 1;108(4):851-9. doi: 10.1002/jcb.22313. J Cell Biochem. 2009. PMID: 19711372
Inhibition of Src family kinases by PP2 attenuated the pH 6.6-induced tyrosine phosphorylation of E-cadherin and p120ctn, and prevented the loss of these proteins from AJs. In addition, E-cadherin was bound to Hakai and ubiquitinated. Furthermore, pH 6.6-induced detachment …
Inhibition of Src family kinases by PP2 attenuated the pH 6.6-induced tyrosine phosphorylation of E-cadherin and p120ctn, and prevented the …