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Page 1
Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and ER stress-induced cell death.
Wang W, Hawkridge AM, Ma Y, Zhang B, Mangrum JB, Hassan ZH, He T, Blat S, Guo C, Zhou H, Liu J, Wang XY, Fang X. Wang W, et al. J Biol Chem. 2023 Jul;299(7):104915. doi: 10.1016/j.jbc.2023.104915. Epub 2023 Jun 12. J Biol Chem. 2023. PMID: 37315790 Free PMC article.
Biological functions of the highly conserved ubiquitin-like protein 5 (UBL5) are not well understood. In Caenorhabditis elegans, UBL5 is induced under mitochondrial stress to mount the mitochondrial unfolded protein response (UPR). ...
Biological functions of the highly conserved ubiquitin-like protein 5 (UBL5) are not well understood. In Caenorhabditis elegans, UBL5 …
Dynamic neurotransmitter specific transcription factor expression profiles during Drosophila development.
Estacio-Gómez A, Hassan A, Walmsley E, Le LW, Southall TD. Estacio-Gómez A, et al. Biol Open. 2020 Jun 3;9(5):bio052928. doi: 10.1242/bio.052928. Biol Open. 2020. PMID: 32493733 Free PMC article.
Furthermore, our data underlines that, similar to Caenorhabditis elegans, there are no simple transcription factor codes for neurotransmitter type specification.This article has an associated First Person interview with the first author of the paper....
Furthermore, our data underlines that, similar to Caenorhabditis elegans, there are no simple transcription factor codes for neurotra …
A DAF-3 co-Smad molecule functions in Haemonchus contortus development.
Di W, Liu L, Zhang T, Li F, He L, Wang C, Ahmad AA, Hassan M, Fang R, Hu M. Di W, et al. Parasit Vectors. 2019 Dec 27;12(1):609. doi: 10.1186/s13071-019-3855-3. Parasit Vectors. 2019. PMID: 31881930 Free PMC article.
BACKGROUND: The Smad proteins function in TGF-beta signalling transduction. In the model nematode Caenorhabditis elegans, the co-Smad, DAF-3 mediates R-Smads and performs a central role in DAF-7 signal transduction, regulating dauer formation and reproductive processes. .. …
BACKGROUND: The Smad proteins function in TGF-beta signalling transduction. In the model nematode Caenorhabditis elegans, the co-Smad …
Assaying beta-amyloid toxicity using a transgenic C. elegans model.
Dostal V, Link CD. Dostal V, et al. J Vis Exp. 2010 Oct 9;(44):2252. doi: 10.3791/2252. J Vis Exp. 2010. PMID: 20972410 Free PMC article.
Treatments that counter Abeta toxicity in this model [e.g., expression of a protective transgene (Hassan et al. 2009) or exposure to Ginkgo biloba extracts (Wu et al. 2006)] reproducibly alter the rate of paralysis induced by temperature upshift of these transgenic worms. …
Treatments that counter Abeta toxicity in this model [e.g., expression of a protective transgene (Hassan et al. 2009) or exposure to …
Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant.
Giorgino T, Mattioni D, Hassan A, Milani M, Mastrangelo E, Barbiroli A, Verhelle A, Gettemans J, Barzago MM, Diomede L, de Rosa M. Giorgino T, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Mar 1;1865(3):648-660. doi: 10.1016/j.bbadis.2019.01.010. Epub 2019 Jan 6. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30625383 Free article.
In particular, the nanobody reduces the flexibility of dynamic stretches, and most notably decreases the conformational entropy of the C-terminal tail, otherwise stabilized by the presence of the Ca(2+) ion. A Caenorhabditis elegans-based assay was also applied to quantify …
In particular, the nanobody reduces the flexibility of dynamic stretches, and most notably decreases the conformational entropy of the C-ter …
H-NS plays a role in expression of Acinetobacter baumannii virulence features.
Eijkelkamp BA, Stroeher UH, Hassan KA, Elbourne LD, Paulsen IT, Brown MH. Eijkelkamp BA, et al. Infect Immun. 2013 Jul;81(7):2574-83. doi: 10.1128/IAI.00065-13. Epub 2013 May 6. Infect Immun. 2013. PMID: 23649094 Free PMC article.
In this study, we examined the virulence features of a hypermotile derivative of A. baumannii strain ATCC 17978, which was found to display enhanced adherence to human pneumocytes and elevated levels of lethality toward Caenorhabditis elegans nematodes. Analysis of cellula …
In this study, we examined the virulence features of a hypermotile derivative of A. baumannii strain ATCC 17978, which was found to display …
Peptide multifunctionalized gold nanorods decrease toxicity of beta-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease.
Morales-Zavala F, Arriagada H, Hassan N, Velasco C, Riveros A, Álvarez AR, Minniti AN, Rojas-Silva X, Muñoz LL, Vasquez R, Rodriguez K, Sanchez-Navarro M, Giralt E, Araya E, Aldunate R, Kogan MJ. Morales-Zavala F, et al. Nanomedicine. 2017 Oct;13(7):2341-2350. doi: 10.1016/j.nano.2017.06.013. Epub 2017 Jun 30. Nanomedicine. 2017. PMID: 28673851
We also showed that when we apply our nanosystem to a Caenorhabditis elegans AD model, the toxicity of aggregated Abeta peptide is decreased. ...
We also showed that when we apply our nanosystem to a Caenorhabditis elegans AD model, the toxicity of aggregated Abeta peptide is de …
AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model.
Hassan WM, Merin DA, Fonte V, Link CD. Hassan WM, et al. Hum Mol Genet. 2009 Aug 1;18(15):2739-47. doi: 10.1093/hmg/ddp209. Epub 2009 May 3. Hum Mol Genet. 2009. PMID: 19414486 Free PMC article.
Cellular mechanisms involving protein turnover may be key defense mechanisms against aggregating protein disorders. We have used a transgenic Caenorhabditis elegans Alzheimer's disease model to identify cellular responses to proteotoxicity resulting from expression of the …
Cellular mechanisms involving protein turnover may be key defense mechanisms against aggregating protein disorders. We have used a transgeni …
First Report of Twenty-two New Hosts of Potato leafroll virus.
Thomas PE, Hassan S. Thomas PE, et al. Plant Dis. 2002 May;86(5):561. doi: 10.1094/PDIS.2002.86.5.561A. Plant Dis. 2002. PMID: 30818692 Free article.
., S. sarrachoides Sendtner, S. demissum L. (P.I. 230579), Spinacia oleraceae L., and Zinnia elegans Jaeq. In light of these new hosts, reevaluation of the epidemiology of PLRV may be advisable in regions where new virus hosts also host aphid vectors and where a virus host …
., S. sarrachoides Sendtner, S. demissum L. (P.I. 230579), Spinacia oleraceae L., and Zinnia elegans Jaeq. In light of these new host …
13 results