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1976 1
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2002 1
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2023 5
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43 results

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An atlas of healthy and injured cell states and niches in the human kidney.
Lake BB, Menon R, Winfree S, Hu Q, Melo Ferreira R, Kalhor K, Barwinska D, Otto EA, Ferkowicz M, Diep D, Plongthongkum N, Knoten A, Urata S, Mariani LH, Naik AS, Eddy S, Zhang B, Wu Y, Salamon D, Williams JC, Wang X, Balderrama KS, Hoover PJ, Murray E, Marshall JL, Noel T, Vijayan A, Hartman A, Chen F, Waikar SS, Rosas SE, Wilson FP, Palevsky PM, Kiryluk K, Sedor JR, Toto RD, Parikh CR, Kim EH, Satija R, Greka A, Macosko EZ, Kharchenko PV, Gaut JP, Hodgin JB; KPMP Consortium; Eadon MT, Dagher PC, El-Achkar TM, Zhang K, Kretzler M, Jain S. Lake BB, et al. Nature. 2023 Jul;619(7970):585-594. doi: 10.1038/s41586-023-05769-3. Epub 2023 Jul 19. Nature. 2023. PMID: 37468583 Free PMC article.
Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interactions within tissue neighbourhoods(1). Here we applied multiple single-cell and single-nucleus assays (>400,000 nuclei or cells) and s …
Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interaction …
Enhancement strategies for mesenchymal stem cells and related therapies.
Alagesan S, Brady J, Byrnes D, Fandiño J, Masterson C, McCarthy S, Laffey J, O'Toole D. Alagesan S, et al. Among authors: o toole d. Stem Cell Res Ther. 2022 Feb 21;13(1):75. doi: 10.1186/s13287-022-02747-w. Stem Cell Res Ther. 2022. PMID: 35189962 Free PMC article. Review.
These enhanced MSCs will lead the way in more difficult to treat diseases and restore potency where donors or manufacturing practicalities lead to diminished MSC effect....
These enhanced MSCs will lead the way in more difficult to treat diseases and restore potency where donors or manufacturing practical …
Rationale and design of the Kidney Precision Medicine Project.
de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, He Y, Hodgin JB, Jain S, Kellum JA, Kiryluk K, Knight R, Laszik ZG, Lienczewski C, Mariani LH, McClelland RL, Menez S, Moledina DG, Mooney SD, O'Toole JF, Palevsky PM, Parikh CR, Poggio ED, Rosas SE, Rosengart MR, Sarwal MM, Schaub JA, Sedor JR, Sharma K, Steck B, Toto RD, Troyanskaya OG, Tuttle KR, Vazquez MA, Waikar SS, Williams K, Wilson FP, Zhang K, Iyengar R, Kretzler M, Himmelfarb J; Kidney Precision Medicine Project. de Boer IH, et al. Among authors: o toole jf. Kidney Int. 2021 Mar;99(3):498-510. doi: 10.1016/j.kint.2020.08.039. Kidney Int. 2021. PMID: 33637194 Free PMC article.
This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-don …
This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD at …
Engraftment of aging-related human gut microbiota and the effect of a seven-species consortium in a pre-clinical model.
Ye H, Ghosh TS, Hueston CM, Vlckova K, Golubeva AV, Hyland NP, O'Toole PW. Ye H, et al. Among authors: o toole pw. Gut Microbes. 2023 Dec;15(2):2282796. doi: 10.1080/19490976.2023.2282796. Epub 2023 Nov 27. Gut Microbes. 2023. PMID: 38010168 Free PMC article.
Inoculation with a frail or a healthy donor microbiome resulted in differential microbiota compositions in murine recipients 5 weeks post-transplantation. Fecal acetate levels were significantly higher in healthy donor recipient mice than in frail donor recip …
Inoculation with a frail or a healthy donor microbiome resulted in differential microbiota compositions in murine recipients 5 weeks …
The Will Reconsidered: Hard Choices in Living Organ Donation.
Guerin RM, O'Toole E, Daly B. Guerin RM, et al. Among authors: o toole e. Narrat Inq Bioeth. 2018;8(2):179-186. doi: 10.1353/nib.2018.0055. Narrat Inq Bioeth. 2018. PMID: 30220701
In the following article, we illustrate an interview between a living donor advocate and a potential living organ donor in which the donor faced a hard choice: the reasons to donate and the reasons not to donate were equally persuasive. ...But we think that t …
In the following article, we illustrate an interview between a living donor advocate and a potential living organ donor in whi …
Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene.
Chisholm DR, Lamb R, Pallett T, Affleck V, Holden C, Marrison J, O'Toole P, Ashton PD, Newling K, Steffen A, Nelson AK, Mahler C, Valentine R, Blacker TS, Bain AJ, Girkin J, Marder TB, Whiting A, Ambler CA. Chisholm DR, et al. Among authors: o toole p. Chem Sci. 2019 Mar 21;10(17):4673-4683. doi: 10.1039/c9sc00199a. eCollection 2019 May 7. Chem Sci. 2019. PMID: 31123578 Free PMC article.
Diet influences the functions of the human intestinal microbiome.
De Angelis M, Ferrocino I, Calabrese FM, De Filippis F, Cavallo N, Siragusa S, Rampelli S, Di Cagno R, Rantsiou K, Vannini L, Pellegrini N, Lazzi C, Turroni S, Lorusso N, Ventura M, Chieppa M, Neviani E, Brigidi P, O'Toole PW, Ercolini D, Gobbetti M, Cocolin L. De Angelis M, et al. Among authors: o toole pw. Sci Rep. 2020 Mar 6;10(1):4247. doi: 10.1038/s41598-020-61192-y. Sci Rep. 2020. PMID: 32144387 Free PMC article.
Microbial cells and flagellin extracted from fecal samples of 61 healthy donors modulated the viability of the human (HT29) colon carcinoma cells and the host response through the stimulation of the expression of Toll-like receptor 5, lectin RegIIIalpha and three interleuk …
Microbial cells and flagellin extracted from fecal samples of 61 healthy donors modulated the viability of the human (HT29) colon car …
Characteristics of Potential and Actual Living Kidney Donors: A Single-center Experience.
Cholin LK, Schold JD, Arrigain S, Poggio ED, Sedor JR, O'Toole JF, Augustine JJ, Wee AC, Huml AM. Cholin LK, et al. Among authors: o toole jf. Transplantation. 2023 Apr 1;107(4):941-951. doi: 10.1097/TP.0000000000004357. Epub 2022 Nov 21. Transplantation. 2023. PMID: 36476994
BACKGROUND: There are limited data and no national capture of barriers associated with initiating and completing the donation process for potential living kidney donors (LKDs). METHODS: We performed a retrospective analysis of 3001 intake forms completed by prospective LKD …
BACKGROUND: There are limited data and no national capture of barriers associated with initiating and completing the donation process for po …
Podocyte density is reduced in kidney allografts with high-risk APOL1 genotypes at transplantation.
Chen DP, Zaky ZS, Schold JD, Herlitz LC, El-Rifai R, Drawz PE, Bruggeman LA, Barisoni L, Hogan SL, Hu Y, O'Toole JF, Poggio ED, Sedor JR. Chen DP, et al. Among authors: o toole jf. Clin Transplant. 2021 Apr;35(4):e14234. doi: 10.1111/ctr.14234. Epub 2021 Feb 10. Clin Transplant. 2021. PMID: 33511679 Free PMC article.
Demographic characteristics were similar in high-risk (n = 16) and low-risk (n = 91) donors. Podocyte density was significantly lower in high-risk than low-risk donors (108 26 vs 127 40 podocytes/10(6) um(3) , P = .03). ...At 60 months, eGFR was 27 vs. 51 mL/min/1.7 …
Demographic characteristics were similar in high-risk (n = 16) and low-risk (n = 91) donors. Podocyte density was significantly lower …
Live Donation of Corneal Tissue in the Setting of Orbital Exenteration for Malignancy.
Azad F, Schiff J, Macias R, O'Toole T, Cheung VWF. Azad F, et al. Among authors: o toole t. Eplasty. 2022 Jun 13;22:e17. eCollection 2022. Eplasty. 2022. PMID: 35873070 Free PMC article.
Background. The availability of corneal tissue is a major limiting factor in utilizing keratoplasty for correction of corneal blindness. ...As a result, the possibility of obtaining viable corneal tissue from a living donor is rarely discussed. This report de …
Background. The availability of corneal tissue is a major limiting factor in utilizing keratoplasty for correction of corneal blindne …
43 results