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2008 2
2013 1
2014 1
2015 2
2016 3
2017 1
2018 1
2019 1
2020 1
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2024 0

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Page 1
The crystal structure of Cpf1 in complex with CRISPR RNA.
Dong D, Ren K, Qiu X, Zheng J, Guo M, Guan X, Liu H, Li N, Zhang B, Yang D, Ma C, Wang S, Wu D, Ma Y, Fan S, Wang J, Gao N, Huang Z. Dong D, et al. Nature. 2016 Apr 28;532(7600):522-6. doi: 10.1038/nature17944. Epub 2016 Apr 20. Nature. 2016. PMID: 27096363
The CRISPR-Cas systems, as exemplified by CRISPR-Cas9, are RNA-guided adaptive immune systems used by bacteria and archaea to defend against viral infection. The CRISPR-Cpf1 system, a new class 2 CRISPR-Cas system, mediates robust DNA interference in human cells. ...
The CRISPR-Cas systems, as exemplified by CRISPR-Cas9, are RNA-guided adaptive immune systems used by bacteria and archaea to defend …
Quasi-opsonin conjugated lipase-sensitive micelles activate macrophages against facultative intracellular bacterial infection.
Liu X, Wang Y, Zou J, Wang H, Li X, Huang Y, Hu E, Guan Z, Quan D, Liu J, Zhang W. Liu X, et al. J Mater Chem B. 2023 Jan 25;11(4):865-878. doi: 10.1039/d2tb01802k. J Mater Chem B. 2023. PMID: 36594907
Bacteria phagocytosed by macrophages have evolved a variety of mechanisms to defend against host attack, and the poor entry of antibiotics into infected macrophages is conducive to the survival of intracellular bacteria. ...
Bacteria phagocytosed by macrophages have evolved a variety of mechanisms to defend against host attack, and the poor entry of antibi …
Structural characterization and regulation of the mechanical properties of the carapace cuticle in tri-spine horseshoe crab (Tachypleus tridentatus).
Ma Y, Guo C, Dai N, Shen J, Guan J. Ma Y, et al. J Mech Behav Biomed Mater. 2022 Jan;125:104954. doi: 10.1016/j.jmbbm.2021.104954. Epub 2021 Oct 30. J Mech Behav Biomed Mater. 2022. PMID: 34741983
Horseshoe crab (order Xiphosura) has a large and thick carapace that has evolved as a protective tool to defend against predators and resist impacts from surf-zone turbulence. ...
Horseshoe crab (order Xiphosura) has a large and thick carapace that has evolved as a protective tool to defend against predators and …
Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders.
Pan ZS, Chen YL, Tang KJ, Liu ZZ, Liang JL, Guan YH, Xin XY, Liu CH, Shen CP. Pan ZS, et al. Exp Ther Med. 2023 May 15;26(1):320. doi: 10.3892/etm.2023.12019. eCollection 2023 Jul. Exp Ther Med. 2023. PMID: 37273757 Free PMC article.
Molecular docking studies were performed to explore the potential targets of Pac in defending against lipid deposition. MPHs isolated from liver-specific SIRT6-deficient mice were subjected to OA + PA incubation and treated with Pac to determine the function and detailed m …
Molecular docking studies were performed to explore the potential targets of Pac in defending against lipid deposition. MPHs isolated …
LC3-association with the parasitophorous vacuole membrane of Plasmodium berghei liver stages follows a noncanonical autophagy pathway.
Wacker R, Eickel N, Schmuckli-Maurer J, Annoura T, Niklaus L, Khan SM, Guan JL, Heussler VT. Wacker R, et al. Cell Microbiol. 2017 Oct;19(10). doi: 10.1111/cmi.12754. Epub 2017 Jun 19. Cell Microbiol. 2017. PMID: 28573684 Free article.
Eukaryotic cells can employ autophagy to defend themselves against invading pathogens. Upon infection by Plasmodium berghei sporozoites, the host hepatocyte targets the invader by labelling the parasitophorous vacuole membrane (PVM) with the autophagy marker protein LC3. . …
Eukaryotic cells can employ autophagy to defend themselves against invading pathogens. Upon infection by Plasmodium berghei sporozoit …
Human CRP defends against the toxicity of circulating histones.
Abrams ST, Zhang N, Dart C, Wang SS, Thachil J, Guan Y, Wang G, Toh CH. Abrams ST, et al. J Immunol. 2013 Sep 1;191(5):2495-502. doi: 10.4049/jimmunol.1203181. Epub 2013 Jul 26. J Immunol. 2013. PMID: 23894199
The generic function of this highly conserved molecule in diseases that range from infection, inflammation, trauma, and malignancy is not well understood. In this article, we demonstrate that CRP defends the human body against the toxicity of histones released into the cir …
The generic function of this highly conserved molecule in diseases that range from infection, inflammation, trauma, and malignancy is not we …
Modeling Resources Allocation in Attacker-Defender Games with "Warm Up" CSF.
Guan P, Zhuang J. Guan P, et al. Risk Anal. 2016 Apr;36(4):776-91. doi: 10.1111/risa.12502. Epub 2015 Dec 29. Risk Anal. 2016. PMID: 26713543
Like many other engineering investments, the attacker's and defender's investments may have limited impact without initial capital to "warm up" the systems. ...We illustrate the model results with real data, and compare the results of the models with and without con …
Like many other engineering investments, the attacker's and defender's investments may have limited impact without initial cap …
New insights into an RNAi approach for plant defence against piercing-sucking and stem-borer insect pests.
Li H, Guan R, Guo H, Miao X. Li H, et al. Plant Cell Environ. 2015 Nov;38(11):2277-85. doi: 10.1111/pce.12546. Epub 2015 May 12. Plant Cell Environ. 2015. PMID: 25828885 Free article.
Insect double-stranded (ds)RNA expression in transgenic crops can increase plant resistance to biotic stress; however, creating transgenic crops to defend against every insect pest is impractical. Arabidopsis Mob1A is required for organ growth and reproduction. ...
Insect double-stranded (ds)RNA expression in transgenic crops can increase plant resistance to biotic stress; however, creating transgenic c …
Identifying optimal targets of network attack by belief propagation.
Mugisha S, Zhou HJ. Mugisha S, et al. Phys Rev E. 2016 Jul;94(1-1):012305. doi: 10.1103/PhysRevE.94.012305. Epub 2016 Jul 11. Phys Rev E. 2016. PMID: 27575146
The BPD-guided attack scheme often induces an abrupt collapse of the whole network, which may make it very difficult to defend....
The BPD-guided attack scheme often induces an abrupt collapse of the whole network, which may make it very difficult to defend....
An M29 Aminopeptidase from Listeria Monocytogenes Contributes to In Vitro Bacterial Growth but not to Intracellular Infection.
Zhang X, Guan C, Hang Y, Liu F, Sun J, Yu H, Gan L, Zeng H, Zhu Y, Chen Z, Song H, Cheng C. Zhang X, et al. Microorganisms. 2020 Jan 13;8(1):110. doi: 10.3390/microorganisms8010110. Microorganisms. 2020. PMID: 31941013 Free PMC article.
Taken together, we conclude that LmAmpII, an M29 family aminopeptidase, can efficiently hydrolyze a wide range of substrates and is required for in vitro bacterial growth, which lays a foundation for in-depth investigations of aminopeptidases as potential targets to defend …
Taken together, we conclude that LmAmpII, an M29 family aminopeptidase, can efficiently hydrolyze a wide range of substrates and is required …
14 results