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Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury.
Huttinger AL, Wheeler DG, Gnyawali S, Dornbos D 3rd, Layzer JM, Venetos N, Talentino S, Musgrave NJ, Jones C, Bratton C, Joseph ME, Sen C, Sullenger BA, Nimjee SM. Huttinger AL, et al. J Vis Exp. 2018 Sep 7;(139):57981. doi: 10.3791/57981. J Vis Exp. 2018. PMID: 30247470 Free PMC article.
Here, we have translated a vascular injury model from a small animal into a large animal (canine), with slight modifications that can be used for pre-clinical screening of prophylactic and thrombolytic agents. ...In addition, specific procedural changes from the previously …
Here, we have translated a vascular injury model from a small animal into a large animal (canine), with slight modifications that can …
Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels.
Nimjee SM, Dornbos D 3rd, Pitoc GA, Wheeler DG, Layzer JM, Venetos N, Huttinger A, Talentino SE, Musgrave NJ, Moody H, Rempel RE, Jones C, Carlisle K, Wilson J, Bratton C, Joseph ME, Khan S, Hoffman MR, Sommerville L, Becker RC, Zweier JL, Sullenger BA. Nimjee SM, et al. Mol Ther. 2019 Jul 3;27(7):1228-1241. doi: 10.1016/j.ymthe.2019.03.016. Epub 2019 Mar 30. Mol Ther. 2019. PMID: 30987839 Free PMC article.
Moreover, DTRI-031 can achieve potent vascular recanalization of platelet-rich thrombotic occlusions in murine and canine carotid arteries. Finally, DTRI-031 activity is rapidly (<5 min) and completely reversed by AO administration in a murine saphenous vein hemorrhage …
Moreover, DTRI-031 can achieve potent vascular recanalization of platelet-rich thrombotic occlusions in murine and canine carotid art …
Functional repair of a mutant chloride channel using a trans-splicing ribozyme.
Rogers CS, Vanoye CG, Sullenger BA, George AL Jr. Rogers CS, et al. J Clin Invest. 2002 Dec;110(12):1783-9. doi: 10.1172/JCI16481. J Clin Invest. 2002. PMID: 12488428 Free PMC article.
Modified Tetrahymena group I intron ribozymes have been used to mediate trans-splicing of therapeutically relevant RNA transcripts, but the efficiency of the ribozyme-mediated RNA repair process has not been determined precisely and subsequent restoration of protein function has …
Modified Tetrahymena group I intron ribozymes have been used to mediate trans-splicing of therapeutically relevant RNA transcripts, but the …