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1987 1
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Page 1
mPR-Specific Actions Influence Maintenance of the Blood-Brain Barrier (BBB).
Abou-Fadel J, Jiang X, Padarti A, Goswami DG, Smith M, Grajeda B, Bhalli M, Le A, Walker WE, Zhang J. Abou-Fadel J, et al. Int J Mol Sci. 2022 Aug 26;23(17):9684. doi: 10.3390/ijms23179684. Int J Mol Sci. 2022. PMID: 36077089 Free PMC article.
Disruption of the CSC will result in hemorrhagic CCMs, a consequence of compromised blood-brain barrier (BBB) integrity. Due to their characteristically incomplete penetrance, the majority of CCM mutation carriers (presumed CCM patients) are largely asymptomatic, but when …
Disruption of the CSC will result in hemorrhagic CCMs, a consequence of compromised blood-brain barrier (BBB) integrity. Due to their …
Neurodegenerative Alzheimer-like pathology in PDAPP 717V-->F transgenic mice.
Chen KS, Masliah E, Grajeda H, Guido T, Huang J, Khan K, Motter R, Soriano F, Games D. Chen KS, et al. Prog Brain Res. 1998;117:327-34. Prog Brain Res. 1998. PMID: 9932418 Review.
Neurodegenerative changes, including the loss of synaptic and dendritic proteins, abnormal phosphorylation of cytoskeletal elements, subcellular degenerative changes, and the deposition of lysosomal and acute phase proteins has also been seen in PDAPP mouse brains. Reactiv …
Neurodegenerative changes, including the loss of synaptic and dendritic proteins, abnormal phosphorylation of cytoskeletal elements, subcell …
Primary oligodendroglioma of the septum pellucidum.
Garza-Mercado R, Campa H, Grajeda J. Garza-Mercado R, et al. Neurosurgery. 1987 Jul;21(1):78-80. doi: 10.1227/00006123-198707000-00016. Neurosurgery. 1987. PMID: 3614609
Missense and nonsense mutations of the zebrafish hcfc1a gene result in contrasting mTor and radial glial phenotypes.
Castro VL, Paz D, Virrueta V, Estevao IL, Grajeda BI, Ellis CC, Quintana AM. Castro VL, et al. Gene. 2023 May 15;864:147290. doi: 10.1016/j.gene.2023.147290. Epub 2023 Feb 17. Gene. 2023. PMID: 36804358
Knock-in of the cblX-like allele was associated with increased expression of proteins required for ribosome biogenesis. However, the brain phenotypes were not comprehensively studied due to sub-viability. ...We used a missense, a nonsense, and two conditional zebrafish all …
Knock-in of the cblX-like allele was associated with increased expression of proteins required for ribosome biogenesis. However, the brai …
Circulating Blood Prognostic Biomarker Signatures for Hemorrhagic Cerebral Cavernous Malformations (CCMs).
Croft J, Grajeda B, Aguirre LA, Abou-Fadel JS, Ellis CC, Estevao I, Almeida IC, Zhang J. Croft J, et al. Int J Mol Sci. 2024 Apr 26;25(9):4740. doi: 10.3390/ijms25094740. Int J Mol Sci. 2024. PMID: 38731959 Free PMC article.
Cerebral cavernous malformations (CCMs) are a neurological disorder characterized by enlarged intracranial capillaries in the brain, increasing the susceptibility to hemorrhagic strokes, a major cause of death and disability worldwide. ...
Cerebral cavernous malformations (CCMs) are a neurological disorder characterized by enlarged intracranial capillaries in the brain, …
Prevention and reduction of AD-type pathology in PDAPP mice immunized with A beta 1-42.
Games D, Bard F, Grajeda H, Guido T, Khan K, Soriano F, Vasquez N, Wehner N, Johnson-Wood K, Yednock T, Seubert P, Schenk D. Games D, et al. Ann N Y Acad Sci. 2000;920:274-84. doi: 10.1111/j.1749-6632.2000.tb06936.x. Ann N Y Acad Sci. 2000. PMID: 11193164
In AD certain brain structures contain a pathological density of A beta protein deposited into plaques. ...
In AD certain brain structures contain a pathological density of A beta protein deposited into plaques. ...
Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.
Buttini M, Masliah E, Barbour R, Grajeda H, Motter R, Johnson-Wood K, Khan K, Seubert P, Freedman S, Schenk D, Games D. Buttini M, et al. J Neurosci. 2005 Oct 5;25(40):9096-101. doi: 10.1523/JNEUROSCI.1697-05.2005. J Neurosci. 2005. PMID: 16207868 Free PMC article.
Alzheimer's disease neuropathology is characterized by key features that include the deposition of the amyloid beta peptide (Abeta) into plaques, the formation of neurofibrillary tangles, and the loss of neurons and synapses in specific brain regions. The loss of synapses, …
Alzheimer's disease neuropathology is characterized by key features that include the deposition of the amyloid beta peptide (Abeta) into pla …
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P. Schenk D, et al. Nature. 1999 Jul 8;400(6740):173-7. doi: 10.1038/22124. Nature. 1999. PMID: 10408445
The PDAPP transgenic mouse, which overexpresses mutant human APP (in which the amino acid at position 717 is phenylalanine instead of the normal valine), progressively develops many of the neuropathological hallmarks of Alzheimer's disease in an age- and brain-region-depen …
The PDAPP transgenic mouse, which overexpresses mutant human APP (in which the amino acid at position 717 is phenylalanine instead of the no …
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease.
Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T. Bard F, et al. Nat Med. 2000 Aug;6(8):916-9. doi: 10.1038/78682. Nat Med. 2000. PMID: 10932230
When examined in an ex vivo assay with sections of PDAPP or Alzheimer disease brain tissue, antibodies against amyloid beta-peptide triggered microglial cells to clear plaques through Fc receptor-mediated phagocytosis and subsequent peptide degradation. These results indic …
When examined in an ex vivo assay with sections of PDAPP or Alzheimer disease brain tissue, antibodies against amyloid beta-peptide t …
11 results