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Year Number of Results
1999 1
2001 1
2003 1
2004 3
2007 4
2008 1
2010 1
2011 9
2012 8
2013 9
2014 23
2015 15
2016 12
2017 16
2018 21
2019 23
2020 26
2021 21
2022 34
2023 29
2024 19

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246 results

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Page 1
Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation.
Ma X, Chen A, Melo L, Clemente-Sanchez A, Chao X, Ahmadi AR, Peiffer B, Sun Z, Sesaki H, Li T, Wang X, Liu W, Bataller R, Ni HM, Ding WX. Ma X, et al. Hepatology. 2023 Jan 1;77(1):159-175. doi: 10.1002/hep.32604. Epub 2022 Jul 5. Hepatology. 2023. PMID: 35698731 Free PMC article.
Liver-specific dynamin-related protein 1 (DRP1; gene name DNM1L, an essential gene regulating mitochondria fission ) knockout (L-DRP1 KO) mice and wild-type mice were subjected to chronic plus binge alcohol feeding. Both human AH and alcohol-fed mice had decreased hepatic …
Liver-specific dynamin-related protein 1 (DRP1; gene name DNM1L, an essential gene regulating mitochondria fission ) knockout (L-DRP1 KO) mi …
Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study.
O'Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, Rangarajan S, Islam S, Pais P, McQueen MJ, Mondo C, Damasceno A, Lopez-Jaramillo P, Hankey GJ, Dans AL, Yusoff K, Truelsen T, Diener HC, Sacco RL, Ryglewicz D, Czlonkowska A, Weimar C, Wang X, Yusuf S; INTERSTROKE investigators. O'Donnell MJ, et al. Lancet. 2010 Jul 10;376(9735):112-23. doi: 10.1016/S0140-6736(10)60834-3. Epub 2010 Jun 17. Lancet. 2010. PMID: 20561675
FINDINGS: In the first 3000 cases (n=2337, 78%, with ischaemic stroke; n=663, 22%, with intracerebral haemorrhagic stroke) and 3000 controls, significant risk factors for all stroke were: history of hypertension (OR 2.64, 99% CI 2.26-3.08; PAR 34.6%, 99% CI 30.4-39.1); current sm …
FINDINGS: In the first 3000 cases (n=2337, 78%, with ischaemic stroke; n=663, 22%, with intracerebral haemorrhagic stroke) and 3000 controls …
FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease.
You Y, Liu C, Liu T, Tian M, Wu N, Yu Z, Zhao F, Qi J, Zhu Q. You Y, et al. Free Radic Biol Med. 2022 Nov 20;193(Pt 2):808-819. doi: 10.1016/j.freeradbiomed.2022.10.322. Epub 2022 Nov 3. Free Radic Biol Med. 2022. PMID: 36336231
METHODS: Hepatocyte-specific FNDC3B knockdown or control C57BL/6 N mice received a Lieber-DeCarli diet for four weeks, followed by oral gavage (chronic-binge). Primary mouse hepatocytes and cell lines were used for in vitro studies. ...
METHODS: Hepatocyte-specific FNDC3B knockdown or control C57BL/6 N mice received a Lieber-DeCarli diet for four weeks, followed by oral gava …
The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease.
Chu H, Duan Y, Lang S, Jiang L, Wang Y, Llorente C, Liu J, Mogavero S, Bosques-Padilla F, Abraldes JG, Vargas V, Tu XM, Yang L, Hou X, Hube B, Stärkel P, Schnabl B. Chu H, et al. J Hepatol. 2020 Mar;72(3):391-400. doi: 10.1016/j.jhep.2019.09.029. Epub 2019 Oct 10. J Hepatol. 2020. PMID: 31606552 Free PMC article. Clinical Trial.
Mice colonized with different and genetically manipulated C. albicans strains were subjected to the chronic-plus-binge ethanol diet model. Primary hepatocytes were isolated and incubated with candidalysin. ...
Mice colonized with different and genetically manipulated C. albicans strains were subjected to the chronic-plus-binge ethanol diet m …
Probiotic-derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation.
Jiang M, Li F, Liu Y, Gu Z, Zhang L, Lee J, He L, Vatsalya V, Zhang HG, Deng Z, Zhang X, Chen SY, Guo GL, Barve S, McClain CJ, Feng W. Jiang M, et al. Hepatology. 2023 Apr 1;77(4):1164-1180. doi: 10.1002/hep.32608. Epub 2022 Jul 7. Hepatology. 2023. PMID: 35689610 Free PMC article.
We aimed to investigate whether alcohol-induced dysbiosis increased intestinal microRNA194 (miR194) that suppressed Fxr transcription and whether Lactobacillus rhamnosus GG-derived exosome-like nanoparticles (LDNPs) protected against ALD through regulation of intestinal miR194-FX …
We aimed to investigate whether alcohol-induced dysbiosis increased intestinal microRNA194 (miR194) that suppressed Fxr transcription and wh …
Cellular and molecular mechanisms of alcohol-induced osteopenia.
Luo Z, Liu Y, Liu Y, Chen H, Shi S, Liu Y. Luo Z, et al. Cell Mol Life Sci. 2017 Dec;74(24):4443-4453. doi: 10.1007/s00018-017-2585-y. Epub 2017 Jul 3. Cell Mol Life Sci. 2017. PMID: 28674727 Free PMC article. Review.
Types of alcohol consumption vary from light occasional to heavy, binge drinking, and chronic alcohol abuse at all ages. In general, heavy alcohol consumption is widely recognized as a major epidemiological risk factor for chronic diseases and is detrimental to many organs …
Types of alcohol consumption vary from light occasional to heavy, binge drinking, and chronic alcohol abuse at all ages. In general, …
Connectome-based prediction of eating disorder-associated symptomatology.
Chen X, Dong D, Zhou F, Gao X, Liu Y, Wang J, Qin J, Tian Y, Xiao M, Xu X, Li W, Qiu J, Feng T, He Q, Lei X, Chen H. Chen X, et al. Psychol Med. 2023 Sep;53(12):5786-5799. doi: 10.1017/S0033291722003026. Epub 2022 Sep 30. Psychol Med. 2023. PMID: 36177890
METHODS: CPM with ten-fold cross-validation was carried out to probe functional networks that were predictive of ED-associated symptomatology, including body image concerns, binge eating, and compensatory behaviors, within the discovery sample of 660 participants. ...
METHODS: CPM with ten-fold cross-validation was carried out to probe functional networks that were predictive of ED-associated symptomatolog …
Neurobiological mechanisms and related clinical treatment of addiction: a review.
Fang Y, Sun Y, Liu Y, Liu T, Hao W, Liao Y. Fang Y, et al. Psychoradiology. 2022 Dec 16;2(4):180-189. doi: 10.1093/psyrad/kkac021. eCollection 2022 Dec. Psychoradiology. 2022. PMID: 38665277 Free PMC article. Review.
Drug addiction or substance use disorder (SUD), has been conceptualized as a three-stage (i.e. binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation/craving) recurring cycle that involves complex changes in neuroplasticity, reward, motivation, desi …
Drug addiction or substance use disorder (SUD), has been conceptualized as a three-stage (i.e. binge/intoxication, withdrawal/negativ …
Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS.
Tang Y, Yu Y, Li R, Tao Z, Zhang L, Wang X, Qi X, Li Y, Meng T, Qu H, Zhou M, Xu J, Liu J. Tang Y, et al. Front Immunol. 2023 Jun 12;14:1114129. doi: 10.3389/fimmu.2023.1114129. eCollection 2023. Front Immunol. 2023. PMID: 37377971 Free PMC article.
Alveolar macrophages (AMs) can respond to stimuli via synthesis and release of inflammatory mediators through pyroptosis, one form of programmed cell death acting through the nucleotide-binging oligomerization domain-like receptors protein 3 (NLRP3) signaling pathway, resu …
Alveolar macrophages (AMs) can respond to stimuli via synthesis and release of inflammatory mediators through pyroptosis, one form of progra …
246 results