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1965 2
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Page 1
Did you mean building xi (3,110 results)?
News at XI: moving beyond factor Xa inhibitors.
Fredenburgh JC, Weitz JI. Fredenburgh JC, et al. J Thromb Haemost. 2023 Jul;21(7):1692-1702. doi: 10.1016/j.jtha.2023.04.021. Epub 2023 Apr 26. J Thromb Haemost. 2023. PMID: 37116752 Review.
These include fesomersen, an antisense oligonucleotide that reduces the hepatic synthesis of FXI; abelacimab, an antibody that binds to FXI and blocks its activation; and osocimab, an FXIa inhibitory antibody. ...
These include fesomersen, an antisense oligonucleotide that reduces the hepatic synthesis of FXI; abelacimab, an antibody that binds …
Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function.
Niu F, Li Z, Ren Y, Li Z, Guan H, Li Y, Zhang Y, Li Y, Yang J, Qian L, Shi W, Fan X, Li J, Shi L, Yu Y, Xiong Y. Niu F, et al. Redox Biol. 2023 Sep;65:102824. doi: 10.1016/j.redox.2023.102824. Epub 2023 Jul 24. Redox Biol. 2023. PMID: 37517320 Free PMC article.
Transcriptome analysis revealed that staufen double-stranded RNA binding protein 1 (STAU1) is remarkably downregulated in the GIGYF2-depleted ECs. ...Our work discloses that GIGYF2 serving as an RBP enhances the mRNA stability of STAU1 that upregulates LAMTOR4 expression t …
Transcriptome analysis revealed that staufen double-stranded RNA binding protein 1 (STAU1) is remarkably downregulated in the GIGYF2- …
Collagen Type XI Inhibits Lung Cancer-Associated Fibroblast Functions and Restrains the Integrin Binding Site Availability on Collagen Type I Matrix.
Zeltz C, Khalil M, Navab R, Tsao MS. Zeltz C, et al. Int J Mol Sci. 2022 Oct 3;23(19):11722. doi: 10.3390/ijms231911722. Int J Mol Sci. 2022. PMID: 36233024 Free PMC article.
Among the collagen receptors expressed on CAF, we determined that DDR2 and integrin alpha2beta1, but not integrin alpha11beta1, mediated the high-affinity binding to collagen type XI. We further demonstrated that collagen type XI restrained the integrin bi …
Among the collagen receptors expressed on CAF, we determined that DDR2 and integrin alpha2beta1, but not integrin alpha11beta1, mediated the …
TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage.
Tang N, Tian W, Ma GY, Xiao X, Zhou L, Li ZZ, Liu XX, Li CY, Wu KH, Liu W, Wang XY, Gao YY, Yang X, Qi J, Li D, Liu Y, Chen WS, Gao J, Li XQ, Cao W. Tang N, et al. Nat Commun. 2022 Dec 2;13(1):7455. doi: 10.1038/s41467-022-35242-0. Nat Commun. 2022. PMID: 36460692 Free PMC article.
Meanwhile, TRPC's molecular partner - calmodulin - is uncoupled during Trpc1 or Trpc6 deficiency and binds to TLR4's Pococurante site and atypical isoleucine-glutamine-like motif to block the inflammation cascade. Blocking the C-terminal CaM/IP3R binding domain in T …
Meanwhile, TRPC's molecular partner - calmodulin - is uncoupled during Trpc1 or Trpc6 deficiency and binds to TLR4's Pococurante site …
Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy.
Fan Y, Gao Y, Nie L, Hou T, Dan W, Wang Z, Liu T, Wei Y, Wang Y, Liu B, Que T, Lei Y, Zeng J, Ma J, Wei W, Li L. Fan Y, et al. Mol Cell. 2023 Oct 5;83(19):3520-3532.e7. doi: 10.1016/j.molcel.2023.09.007. Mol Cell. 2023. PMID: 37802025 Free article.
Cyclic GMP-AMP synthase (cGAS) binds pathogenic and other cytoplasmic double-stranded DNA (dsDNA) to catalyze the synthesis of cyclic GMP-AMP (cGAMP), which serves as the secondary messenger to activate the STING pathway and innate immune responses. ...
Cyclic GMP-AMP synthase (cGAS) binds pathogenic and other cytoplasmic double-stranded DNA (dsDNA) to catalyze the synthesis of cyclic …
Factor XI binding to activated platelets is mediated by residues R(250), K(255), F(260), and Q(263) within the apple 3 domain.
Ho DH, Baglia FA, Walsh PN. Ho DH, et al. Biochemistry. 2000 Jan 18;39(2):316-23. doi: 10.1021/bi991851q. Biochemistry. 2000. PMID: 10630991
To localize the platelet binding site on factor XI, rationally designed, conformationally constrained synthetic peptides were used to compete with [(125)I]factor XI binding to activated platelets. ...A "gain-of-function" chimera in which the C-terminal …
To localize the platelet binding site on factor XI, rationally designed, conformationally constrained synthetic peptides were …
Prothrombin is a cofactor for the binding of factor XI to the platelet surface and for platelet-mediated factor XI activation by thrombin.
Baglia FA, Walsh PN. Baglia FA, et al. Biochemistry. 1998 Feb 24;37(8):2271-81. doi: 10.1021/bi972113+. Biochemistry. 1998. PMID: 9485373 Retracted.
Since prothrombin and PF1.2 (but not PF1) also displaced HK from its binding site on the Apple 1 domain of factor XI, we conclude that the Kringle II domain of prothrombin competes with HK for binding to the Apple 1 domain of factor XI. Prothrombin (1- …
Since prothrombin and PF1.2 (but not PF1) also displaced HK from its binding site on the Apple 1 domain of factor XI, we concl …
Skeletal muscle myosin promotes coagulation by binding factor XI via its A3 domain and enhancing thrombin-induced factor XI activation.
Morla S, Deguchi H, Zilberman-Rudenko J, Gruber A, McCarty OJT, Srivastava P, Gailani D, Griffin JH. Morla S, et al. J Biol Chem. 2022 Feb;298(2):101567. doi: 10.1016/j.jbc.2022.101567. Epub 2022 Jan 7. J Biol Chem. 2022. PMID: 35007530 Free PMC article.
Here, we discovered direct interactions between immobilized SkM and coagulation factor XI (FXI) using biolayer interferometry (K(d) = 0.2 nM). In contrast, we show that prekallikrein, a FXI homolog, did not bind to SkM, reflecting the specificity of SkM for FXI binding …
Here, we discovered direct interactions between immobilized SkM and coagulation factor XI (FXI) using biolayer interferometry (K(d) = …
TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks.
Ma J, Zhou Y, Pan P, Yu H, Wang Z, Li LL, Wang B, Yan Y, Pan Y, Ye Q, Liu T, Feng X, Xu S, Wang K, Wang X, Jian Y, Ma B, Fan Y, Gao Y, Huang H, Li L. Ma J, et al. Nat Commun. 2023 Mar 31;14(1):1810. doi: 10.1038/s41467-023-37499-5. Nat Commun. 2023. PMID: 37002234 Free PMC article.
However, how this process is regulated remains poorly understood. Here, we demonstrate that TRABID deubiquitinase binds to 53BP1 at endogenous level and regulates 53BP1 retention at DSB sites. ...
However, how this process is regulated remains poorly understood. Here, we demonstrate that TRABID deubiquitinase binds to 53BP1 at e …
11,325 results
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