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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 2
1970 1
1971 3
1972 2
1973 4
1974 3
1975 10
1976 2
1977 2
1978 2
1979 8
1980 5
1981 5
1982 6
1983 2
1984 11
1985 7
1986 4
1987 11
1988 13
1989 19
1990 18
1991 15
1992 29
1993 20
1994 34
1995 31
1996 36
1997 48
1998 51
1999 60
2000 61
2001 68
2002 68
2003 76
2004 119
2005 105
2006 125
2007 128
2008 141
2009 167
2010 236
2011 234
2012 259
2013 311
2014 310
2015 365
2016 315
2017 403
2018 399
2019 401
2020 511
2021 574
2022 586
2023 554
2024 305

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6,517 results

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Page 1
STING inhibitors target the cyclic dinucleotide binding pocket.
Hong Z, Mei J, Li C, Bai G, Maimaiti M, Hu H, Yu W, Sun L, Zhang L, Cheng D, Liao Y, Li S, You Y, Sun H, Huang J, Liu X, Lieberman J, Wang C. Hong Z, et al. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2105465118. doi: 10.1073/pnas.2105465118. Proc Natl Acad Sci U S A. 2021. PMID: 34099558 Free PMC article.
Here, in silico docking identified a potent STING antagonist SN-011 that binds with higher affinity to the cyclic dinucleotide (CDN)-binding pocket of STING than endogenous 2'3'-cGAMP. ...In Trex1(-/-) mice, SN-011 was well tolerated, strongly inhibited hallmarks of …
Here, in silico docking identified a potent STING antagonist SN-011 that binds with higher affinity to the cyclic dinucleotide (CDN)- …
The Role of TDP-43 in Neurodegenerative Disease.
Liao YZ, Ma J, Dou JZ. Liao YZ, et al. Mol Neurobiol. 2022 Jul;59(7):4223-4241. doi: 10.1007/s12035-022-02847-x. Epub 2022 May 2. Mol Neurobiol. 2022. PMID: 35499795 Review.
The miniature CRISPR-Cas12m effector binds DNA to block transcription.
Wu WY, Mohanraju P, Liao C, Adiego-Pérez B, Creutzburg SCA, Makarova KS, Keessen K, Lindeboom TA, Khan TS, Prinsen S, Joosten R, Yan WX, Migur A, Laffeber C, Scott DA, Lebbink JHG, Koonin EV, Beisel CL, van der Oost J. Wu WY, et al. Mol Cell. 2022 Dec 1;82(23):4487-4502.e7. doi: 10.1016/j.molcel.2022.11.003. Epub 2022 Nov 24. Mol Cell. 2022. PMID: 36427491 Free article.
Despite being less than half the size of Cas12a, Cas12m catalyzes auto-processing of a crRNA guide, recognizes a 5'-TTN' protospacer-adjacent motif (PAM), and stably binds a guide-complementary double-stranded DNA (dsDNA). Cas12m has a RuvC domain with a non-canonical cata …
Despite being less than half the size of Cas12a, Cas12m catalyzes auto-processing of a crRNA guide, recognizes a 5'-TTN' protospacer-adjacen …
Editorial.
Liao L, Hu X. Liao L, et al. Methods. 2016 Nov 1;110:1-2. doi: 10.1016/j.ymeth.2016.10.014. Methods. 2016. PMID: 27836021 No abstract available.
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis.
Zhang Q, Luo P, Xia F, Tang H, Chen J, Zhang J, Liu D, Zhu Y, Liu Y, Gu L, Zheng L, Li Z, Yang F, Dai L, Liao F, Xu C, Wang J. Zhang Q, et al. Cell Chem Biol. 2022 Aug 18;29(8):1248-1259.e6. doi: 10.1016/j.chembiol.2022.06.011. Epub 2022 Jul 19. Cell Chem Biol. 2022. PMID: 35858615 Free article.
Among the identified protein targets, we discover that capsaicin directly binds to and inhibits PKM2 and LDHA, and further suppresses the Warburg effect in inflammatory macrophages. ...
Among the identified protein targets, we discover that capsaicin directly binds to and inhibits PKM2 and LDHA, and further suppresses …
A mechanism for oxidative damage repair at gene regulatory elements.
Ray S, Abugable AA, Parker J, Liversidge K, Palminha NM, Liao C, Acosta-Martin AE, Souza CDS, Jurga M, Sudbery I, El-Khamisy SF. Ray S, et al. Nature. 2022 Sep;609(7929):1038-1047. doi: 10.1038/s41586-022-05217-8. Epub 2022 Sep 28. Nature. 2022. PMID: 36171374 Free article.
The binding is increased on chromatin following oxidative damage, and TDP1 enrichment at damaged chromatin is facilitated by NuMA. ...Complementation of NuMA-deficient cells with a mutant that mediates binding to SSBR, or a mitotic separation-of-function mutant, res …
The binding is increased on chromatin following oxidative damage, and TDP1 enrichment at damaged chromatin is facilitated by NuMA. .. …
Heparan sulfates and heparan sulfate binding proteins in sepsis.
Liao YE, Liu J, Arnold K. Liao YE, et al. Front Mol Biosci. 2023 Feb 14;10:1146685. doi: 10.3389/fmolb.2023.1146685. eCollection 2023. Front Mol Biosci. 2023. PMID: 36865384 Free PMC article. Review.
The circulating heparan sulfate fragments may serve as a host defense system by neutralizing dysregulated Heparan sulfate binding proteins or pro-inflammatory molecules in certain circumstances. Understanding heparan sulfates and heparan sulfate binding proteins in …
The circulating heparan sulfate fragments may serve as a host defense system by neutralizing dysregulated Heparan sulfate binding pro …
Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity.
Zeng KW, Wang JK, Wang LC, Guo Q, Liu TT, Wang FJ, Feng N, Zhang XW, Liao LX, Zhao MM, Liu D, Jiang Y, Tu P. Zeng KW, et al. Signal Transduct Target Ther. 2021 Feb 19;6(1):71. doi: 10.1038/s41392-020-00447-6. Signal Transduct Target Ther. 2021. PMID: 33602894 Free PMC article.
Here, we found that the naturally derived small molecule echinacoside (ECH) significantly promotes mitochondrial fusion progression. ECH selectively binds to the previously uncharacterized casein kinase 2 (CK2) alpha' subunit (CK2alpha') as a direct cellular target, and ge …
Here, we found that the naturally derived small molecule echinacoside (ECH) significantly promotes mitochondrial fusion progression. ECH sel …
The ABCs of Sterol Transport.
Plummer AM, Culbertson AT, Liao M. Plummer AM, et al. Annu Rev Physiol. 2021 Feb 10;83:153-181. doi: 10.1146/annurev-physiol-031620-094944. Epub 2020 Nov 3. Annu Rev Physiol. 2021. PMID: 33141631 Review.
Disruption or dysfunction of cholesterol trafficking leads to numerous human diseases. ATP-binding cassette (ABC) transporters play several critical roles in this process, and mutations in these sterol transporters lead to disorders such as Tangier disease and sitosterolem …
Disruption or dysfunction of cholesterol trafficking leads to numerous human diseases. ATP-binding cassette (ABC) transporters play s …
YbeY, éminence grise of ribosome biogenesis.
Liao Z, Schelcher C, Smirnov A. Liao Z, et al. Biochem Soc Trans. 2021 Apr 30;49(2):727-745. doi: 10.1042/BST20200669. Biochem Soc Trans. 2021. PMID: 33929506 Review.
6,517 results