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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1985 1
1986 2
1988 1
1989 1
1991 2
1993 1
1994 1
1995 1
1996 3
1997 5
1998 1
1999 5
2000 3
2001 11
2002 11
2003 9
2004 10
2005 18
2006 20
2007 26
2008 22
2009 42
2010 49
2011 46
2012 50
2013 53
2014 57
2015 66
2016 76
2017 91
2018 107
2019 100
2020 134
2021 134
2022 168
2023 124
2024 85

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1,329 results

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Page 1
Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production.
Yang Z, Huo Y, Zhou S, Guo J, Ma X, Li T, Fan C, Wang L. Yang Z, et al. Cell Metab. 2022 Dec 6;34(12):2018-2035.e8. doi: 10.1016/j.cmet.2022.10.010. Epub 2022 Nov 8. Cell Metab. 2022. PMID: 36351432 Free article.
Here, we demonstrate that, in cancer cells, the UPR component X-box binding protein 1 (XBP1) favors the synthesis and secretion of cholesterol, which activates myeloid-derived suppressor cells (MDSCs) and causes immunosuppression. ...
Here, we demonstrate that, in cancer cells, the UPR component X-box binding protein 1 (XBP1) favors the synthesis and secretion of ch …
A proximity-tagging system to identify membrane protein-protein interactions.
Liu Q, Zheng J, Sun W, Huo Y, Zhang L, Hao P, Wang H, Zhuang M. Liu Q, et al. Nat Methods. 2018 Sep;15(9):715-722. doi: 10.1038/s41592-018-0100-5. Epub 2018 Aug 13. Nat Methods. 2018. PMID: 30104635
We applied this approach to CD28, a critical costimulatory receptor for T lymphocyte activation, and identified known CD28 binding partners and multiple potential interacting proteins. In addition, we demonstrated that this method can identify the interaction between a cel …
We applied this approach to CD28, a critical costimulatory receptor for T lymphocyte activation, and identified known CD28 binding pa …
Study on the mechanism of Tong-Qiao-Huo-Xue decoction regulating apoptosis via ASK1/MKK4/JNK pathway in MCAO/R rats.
Yuan M, Zhang Y, Wang L, Hua Y, Wang Y, Cheng H, Wang N, Wang G, Seto S. Yuan M, et al. Phytomedicine. 2022 Nov;106:154437. doi: 10.1016/j.phymed.2022.154437. Epub 2022 Sep 7. Phytomedicine. 2022. PMID: 36099654
BACKGROUND: Activation of blood stasis is a crucial aspect of stroke treatment, and the Tong-Qiao-Huo-Xue-Decoction (TQHXD) formula is commonly utilized for this purpose. ...Ferulic acid, HSYA, ligustilide, paeoniflorin, and muscone all displayed high binding affini …
BACKGROUND: Activation of blood stasis is a crucial aspect of stroke treatment, and the Tong-Qiao-Huo-Xue-Decoction (TQHXD) formula i …
DNA Sequence-Dependent Binding of Linker Histone gH1 Regulates Nucleosome Conformations.
Zhang H, Huo QY, Gao YQ. Zhang H, et al. J Phys Chem B. 2022 Sep 15;126(36):6771-6779. doi: 10.1021/acs.jpcb.2c03785. Epub 2022 Sep 5. J Phys Chem B. 2022. PMID: 36062461
Sequence-dependent binding between DNA and proteins in chromatin is an essential part of gene expression. ...Moreover, this specific binding induces the entry/exit region of a nucleosome to a tight conformation and regulates the accessibility of core histones. ...
Sequence-dependent binding between DNA and proteins in chromatin is an essential part of gene expression. ...Moreover, this specific …
Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential.
Huo X, Wang C, Yu Z, Peng Y, Wang S, Feng S, Zhang S, Tian X, Sun C, Liu K, Deng S, Ma X. Huo X, et al. J Pineal Res. 2017 May;62(4). doi: 10.1111/jpi.12390. J Pineal Res. 2017. PMID: 28099762
In this study, it was identified that melatonin and its sulfation metabolites were the substrates of oligopeptide transporter (PEPT) 1/2 and organic anion transporter (OAT) 3, respectively. The docking analysis showed that the binding of melatonin to PEPT1/2 was attributed …
In this study, it was identified that melatonin and its sulfation metabolites were the substrates of oligopeptide transporter (PEPT) 1/2 and …
Circular RNA in tumor metastasis.
Zhang C, Ding R, Sun Y, Huo ST, He A, Wen C, Chen H, Du WW, Lai W, Wang H. Zhang C, et al. Mol Ther Nucleic Acids. 2021 Feb 4;23:1243-1257. doi: 10.1016/j.omtn.2021.01.032. eCollection 2021 Mar 5. Mol Ther Nucleic Acids. 2021. PMID: 33717646 Free PMC article. Review.
These circRNAs are categorized into different functional mechanisms, including microRNA (miRNA) sponging, protein binding, regulation of host genes, translation of circRNAs, and exosomal circRNAs. ...
These circRNAs are categorized into different functional mechanisms, including microRNA (miRNA) sponging, protein binding, regulation …
Therapeutic potential of NR4A1 in cancer: Focus on metabolism.
Deng S, Chen B, Huo J, Liu X. Deng S, et al. Front Oncol. 2022 Aug 16;12:972984. doi: 10.3389/fonc.2022.972984. eCollection 2022. Front Oncol. 2022. PMID: 36052242 Free PMC article. Review.
Then its functions extended to fatty acid synthesis by modulating CD36, fatty acid-binding proteins (FABPs), sterol regulatory element-binding protein 1 (SREBP1), glutamine by Myc, mammalian target of rapamycin (mTOR), and hypoxia-inducible factors alpha (HIF-1alpha …
Then its functions extended to fatty acid synthesis by modulating CD36, fatty acid-binding proteins (FABPs), sterol regulatory elemen …
Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH.
Yin CX, Xiong KM, Huo FJ, Salamanca JC, Strongin RM. Yin CX, et al. Angew Chem Int Ed Engl. 2017 Oct 16;56(43):13188-13198. doi: 10.1002/anie.201704084. Epub 2017 Sep 22. Angew Chem Int Ed Engl. 2017. PMID: 28703457 Free PMC article. Review.
This Minireview summarizes the most significant current challenges in the field of thiol-reactive probes for biomedical research and diagnostics, emphasizing the needs and opportunities that have been under-investigated by chemists in the selective probe and sensor field. Progres …
This Minireview summarizes the most significant current challenges in the field of thiol-reactive probes for biomedical research and diagnos …
Crosstalk between m6A modification and alternative splicing during cancer progression.
Zhu ZM, Huo FC, Zhang J, Shan HJ, Pei DS. Zhu ZM, et al. Clin Transl Med. 2023 Oct;13(10):e1460. doi: 10.1002/ctm2.1460. Clin Transl Med. 2023. PMID: 37850412 Free PMC article. Review.
Background N6-methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is added by m6A methyltransferases, removed by m6A demethylases and recognised by m6A-binding proteins. This modification significantly influences carious facets of RNA metabo …
Background N6-methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is added by m6A methyltransferases, remove …
TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities.
Huo Y, Cao K, Kou B, Chai M, Dou S, Chen D, Shi Y, Liu X. Huo Y, et al. Genes Dis. 2022 Sep 5;10(5):1982-1993. doi: 10.1016/j.gendis.2022.08.014. eCollection 2023 Sep. Genes Dis. 2022. PMID: 37492707 Free PMC article. Review.
During tumorigenesis or tumor development, tumor suppressor p53-binding protein 2 (TP53BP2), also known as apoptosis stimulating protein 2 of p53 (ASPP2), plays a critical role in p53 dependent and independent manner. ...
During tumorigenesis or tumor development, tumor suppressor p53-binding protein 2 (TP53BP2), also known as apoptosis stimulating prot …
1,329 results