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Parkin is transcriptionally regulated by the aryl hydrocarbon receptor: Impact on alpha-synuclein protein levels.
González-Barbosa E, García-Aguilar R, Vega L, Cabañas-Cortés MA, Gonzalez FJ, Segovia J, Morales-Lázaro SL, Cisneros B, Elizondo G. González-Barbosa E, et al. Biochem Pharmacol. 2019 Oct;168:429-437. doi: 10.1016/j.bcp.2019.08.002. Epub 2019 Aug 9. Biochem Pharmacol. 2019. PMID: 31404530 Free PMC article.
Parkin (PRKN) is a ubiquitin E3 ligase that catalyzes the ubiquitination of several proteins. Mutations in the human Parkin gene, PRKN, leads to degeneration of dopaminergic (DA) neurons, resulting in autosomal recessive early-onset parkinsonism and the loss of PRKN …
Parkin (PRKN) is a ubiquitin E3 ligase that catalyzes the ubiquitination of several proteins. Mutations in the human Parkin ge …
Stable Au(I) catalysts for oxidant-free C-H Functionalization with Iodoarenes.
Mertens RT, Greif CE, Coogle JT, Berger G, Parkin S, Watson MD, Awuah SG. Mertens RT, et al. J Catal. 2022 Apr;408:109-114. doi: 10.1016/j.jcat.2022.02.019. Epub 2022 Feb 28. J Catal. 2022. PMID: 35368720 Free PMC article.
The development of oxidant-free gold-catalyzed cross coupling reactions involving aryl halides have been hamstrung by the lack of gold catalysts capable of performing oxidative addition at Au(I) centers. Herein, we report the development of novel tricoordinate Au(I) cataly …
The development of oxidant-free gold-catalyzed cross coupling reactions involving aryl halides have been hamstrung by the lack of gol …
2,3,7,8-Tetrachlorodibenzo-p-dioxin and kynurenine induce Parkin expression in neuroblastoma cells through different signaling pathways mediated by the aryl hydrocarbon receptor.
Murillo-González FE, García-Aguilar R, Limón-Pacheco J, Cabañas-Cortés MA, Elizondo G. Murillo-González FE, et al. Toxicol Lett. 2024 Apr;394:114-127. doi: 10.1016/j.toxlet.2024.02.015. Epub 2024 Mar 2. Toxicol Lett. 2024. PMID: 38437907
Parkin regulates protein degradation and mitophagy in dopaminergic neurons. ...In contrast, Parkin overexpression promotes neuronal survival. Therefore, the mechanisms of Parkin upregulation are crucial to understand. ...
Parkin regulates protein degradation and mitophagy in dopaminergic neurons. ...In contrast, Parkin overexpression promotes neu …
Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei.
Tetaud E, Giroud C, Prescott AR, Parkin DW, Baltz D, Biteau N, Baltz T, Fairlamb AH. Tetaud E, et al. Mol Biochem Parasitol. 2001 Sep 3;116(2):171-83. doi: 10.1016/s0166-6851(01)00320-6. Mol Biochem Parasitol. 2001. PMID: 11522350
In trypanosomatids, removal of hydrogen peroxide and other aryl and alkyl peroxides is achieved by the NADPH-dependent trypanothione peroxidase system, whose components are trypanothione reductase (TRYR), trypanothione, tryparedoxin (TRYX) and tryparedoxin peroxidase (TRYP …
In trypanosomatids, removal of hydrogen peroxide and other aryl and alkyl peroxides is achieved by the NADPH-dependent trypanothione …
Crystal structure and density functional theory studies of toxic quinone metabolites of polychlorinated biphenyls.
Song Y, Ambati J, Parkin S, Rankin SE, Robertson LW, Lehmler HJ. Song Y, et al. Chemosphere. 2011 Oct;85(3):386-92. doi: 10.1016/j.chemosphere.2011.07.004. Epub 2011 Aug 6. Chemosphere. 2011. PMID: 21824639 Free PMC article.
Although these PCB metabolites elicit biochemical changes by mechanisms involving cellular target molecules, such as the aryl hydrocarbon receptor, and toxicity by interacting with enzymes like topoisomerases, only few PCB quinones have been synthesized and their conformat …
Although these PCB metabolites elicit biochemical changes by mechanisms involving cellular target molecules, such as the aryl hydroca …
Retention of triplicated phytoene synthase (PSY) genes in Brassica napus L. and its diploid progenitors during the evolution of the Brassiceae.
Cárdenas PD, Gajardo HA, Huebert T, Parkin IA, Iniguez-Luy FL, Federico ML. Cárdenas PD, et al. Theor Appl Genet. 2012 May;124(7):1215-28. doi: 10.1007/s00122-011-1781-7. Epub 2012 Jan 13. Theor Appl Genet. 2012. PMID: 22241480
Considering that diploid Brassica genomes contain three Arabidopsis-like subgenomes, the objectives of the present work were to determine whether PSY gene families exist in B. napus (AACC) and its diploid progenitor species, Brassica rapa (AA) and Brassica oleracea (CC); to estab …
Considering that diploid Brassica genomes contain three Arabidopsis-like subgenomes, the objectives of the present work were to determine wh …