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Nivolumab plus low-dose ipilimumab in previously treated patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: 4-year follow-up from CheckMate 142.
André T, Lonardi S, Wong KYM, Lenz HJ, Gelsomino F, Aglietta M, Morse MA, Van Cutsem E, McDermott R, Hill A, Sawyer MB, Hendlisz A, Neyns B, Abdullaev S, Memaj A, Lei M, Dixon M, Kopetz S, Overman MJ. André T, et al. Ann Oncol. 2022 Oct;33(10):1052-1060. doi: 10.1016/j.annonc.2022.06.008. Epub 2022 Jun 25. Ann Oncol. 2022. PMID: 35764271 Free article.
BACKGROUND: In the phase II multicohort CheckMate 142 study, nivolumab plus low-dose (1 mg/kg) ipilimumab provided robust and durable clinical benefit with a manageable safety profile in previously treated patients with microsatellite instability-high/mismatch repair-defic …
BACKGROUND: In the phase II multicohort CheckMate 142 study, nivolumab plus low-dose (1 mg/kg) ipilimumab provided robust and durable …
Zanidatamab for HER2-amplified, unresectable, locally advanced or metastatic biliary tract cancer (HERIZON-BTC-01): a multicentre, single-arm, phase 2b study.
Harding JJ, Fan J, Oh DY, Choi HJ, Kim JW, Chang HM, Bao L, Sun HC, Macarulla T, Xie F, Metges JP, Ying J, Bridgewater J, Lee MA, Tejani MA, Chen EY, Kim DU, Wasan H, Ducreux M, Bao Y, Boyken L, Ma J, Garfin P, Pant S; HERIZON-BTC-01 study group. Harding JJ, et al. Lancet Oncol. 2023 Jul;24(7):772-782. doi: 10.1016/S1470-2045(23)00242-5. Epub 2023 Jun 2. Lancet Oncol. 2023. PMID: 37276871 Clinical Trial.
Anti-tumour activity and safety were assessed in all participants who received any dose of zanidatamab. This trial is registered with ClinicalTrials.gov, NCT04466891, is ongoing, and is closed to recruitment. ...
Anti-tumour activity and safety were assessed in all participants who received any dose of zanidatamab. This trial is registered with …
Dissociative Amnesia: A Mist Over Psychosis.
Almaazmi BM, Aldweik AN, Mukhtar MA. Almaazmi BM, et al. Cureus. 2023 Sep 3;15(9):e44619. doi: 10.7759/cureus.44619. eCollection 2023 Sep. Cureus. 2023. PMID: 37799250 Free PMC article.
He had gaps in his autobiographical memory that, upon receiving a regular dose of benzodiazepines, unraveled bizarre, uncooperative, and agitated behavior as well as marked fluctuations in his daily mental state examinations. ...
He had gaps in his autobiographical memory that, upon receiving a regular dose of benzodiazepines, unraveled bizarre, uncooperative, …
Comparing oxygen demand in critical covid-19 patients using single versus double doses of tocilizumab.
Althemery AU, Albadi MA, Allaf AF, Almoqren SS, Alnajjar AH, Alkholifi FK. Althemery AU, et al. Saudi Med J. 2023 May;44(5):513-517. doi: 10.15537/smj.2023.44.5.20220755. Saudi Med J. 2023. PMID: 37182918 Free PMC article.
METHODS: This cross-sectional study was carried out from January 2020 to March 2020. Patients diagnosed with COVID-19, who received at least one dose of tocilizumab, were included. The dependent variable was tocilizumab dose (single versus double). The primary outco …
METHODS: This cross-sectional study was carried out from January 2020 to March 2020. Patients diagnosed with COVID-19, who received at least …
Comparison of Oleocanthal-Low EVOO and Oleocanthal against Amyloid-β and Related Pathology in a Mouse Model of Alzheimer's Disease.
Abdallah IM, Al-Shami KM, Alkhalifa AE, Al-Ghraiybah NF, Guillaume C, Kaddoumi A. Abdallah IM, et al. Molecules. 2023 Jan 27;28(3):1249. doi: 10.3390/molecules28031249. Molecules. 2023. PMID: 36770920 Free PMC article.
Homozygous 5xFAD mice were fed with refined olive oil (ROO), OC-low EVOO, or OC for 3 months starting at the age of 3 months. Our findings demonstrated that a low dose of 0.5 mg/kg EVOO-phenols and OC reduced brain Abeta levels and neuroinflammation by suppressing the nucl …
Homozygous 5xFAD mice were fed with refined olive oil (ROO), OC-low EVOO, or OC for 3 months starting at the age of 3 months. Our findings d …
A Young Adult with Unintended Acute Intravenous Iron Intoxication Treated with Oral Chelation: The Use of Liver Ferriscan for Diagnosing and Monitoring Tissue Iron Load.
Yassin M, Soliman AT, De Sanctis V, Moustafa A, Samaan SA, Nashwan A. Yassin M, et al. Mediterr J Hematol Infect Dis. 2017 Jan 1;9(1):e2017008. doi: 10.4084/MJHID.2017.008. eCollection 2017. Mediterr J Hematol Infect Dis. 2017. PMID: 28101313 Free PMC article.
Her hemogram, electrolytes, hepatic and renal functions were normal. Based on the high dose of iron received and her elevated LIC, chelation therapy was advised. She accepted only oral therapy and was started on deferasirox at a dose of 30 mg/kg daily. This oral che …
Her hemogram, electrolytes, hepatic and renal functions were normal. Based on the high dose of iron received and her elevated LIC, ch …