Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling.
Dalton G, An SW, Al-Juboori SI, Nischan N, Yoon J, Dobrinskikh E, Hilgemann DW, Xie J, Luby-Phelps K, Kohler JJ, Birnbaumer L, Huang CL.
Dalton G, et al.
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):752-757. doi: 10.1073/pnas.1620301114. Epub 2017 Jan 9.
Proc Natl Acad Sci U S A. 2017.
PMID: 28069944
Free PMC article.
Klotho binding to rafts alters lipid organization, decreases membrane's propensity to form large ordered domains for endocytosis, and down-regulates raft-dependent PI3K/Akt signaling. ...
Klotho binding to rafts alters lipid organization, decreases membrane's propensity to form large ordered domains for endocytosis, and …