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Page 1
Discovery of a new class of glucosylceramide synthase inhibitors.
Koltun E, Richards S, Chan V, Nachtigall J, Du H, Noson K, Galan A, Aay N, Hanel A, Harrison A, Zhang J, Won KA, Tam D, Qian F, Wang T, Finn P, Ogilvie K, Rosen J, Mohan R, Larson C, Lamb P, Nuss J, Kearney P. Koltun E, et al. Among authors: chan v. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6773-7. doi: 10.1016/j.bmcl.2011.09.037. Epub 2011 Sep 17. Bioorg Med Chem Lett. 2011. PMID: 21974949
Measuring Movement Quality of the Stroke-Impaired Upper Extremity with a Wearable Sensor: Toward a Smoothness Metric for Home Rehabilitation Exercise Programs.
Okita S, De Lucena DS, Chan V, Reinkensmeyer DJ. Okita S, et al. Among authors: chan v. Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:6691-6694. doi: 10.1109/EMBC46164.2021.9629578. Annu Int Conf IEEE Eng Med Biol Soc. 2021. PMID: 34892643
Using wrist-worn IMU measurements from 19 participants with chronic stroke performing a sample exercise in which they picked up and moved blocks across a divider (i.e. the Box and Blocks Test) we show that Peak Intensity is moderately correlated with a widely used measure …
Using wrist-worn IMU measurements from 19 participants with chronic stroke performing a sample exercise in which they picked up and moved bl …
Discovery and characterization of an inhibitor of glucosylceramide synthase.
Richards S, Larson CJ, Koltun ES, Hanel A, Chan V, Nachtigall J, Harrison A, Aay N, Du H, Arcalas A, Galan A, Zhang J, Zhang W, Won KA, Tam D, Qian F, Wang T, Finn P, Ogilvie K, Rosen J, Aoyama R, Plonowski A, Cancilla B, Bentzien F, Yakes M, Mohan R, Lamb P, Nuss J, Kearney P. Richards S, et al. Among authors: chan v. J Med Chem. 2012 May 10;55(9):4322-35. doi: 10.1021/jm300122u. Epub 2012 Apr 19. J Med Chem. 2012. PMID: 22497444
There is plenty of room for motor learning at the bottom of the Fugl-Meyer: Acquisition of a novel bimanual wheelchair skill after chronic stroke using an unmasking technology.
Sarigul-Klijn Y, Lobo-Prat J, Smith BW, Thayer S, Zondervan D, Chan V, Stoller O, Reinkensmeyer DJ. Sarigul-Klijn Y, et al. Among authors: chan v. IEEE Int Conf Rehabil Robot. 2017 Jul;2017:50-55. doi: 10.1109/ICORR.2017.8009220. IEEE Int Conf Rehabil Robot. 2017. PMID: 28813792 Free PMC article.
They did this by learning a bimanual skill: pushing the levers with both arms while activating the yoked-clutches at the right time with their ipsilesional (i.e. "good") hand to propel the wheelchair forward. They perceived the task as highly motivating and useful. ...
They did this by learning a bimanual skill: pushing the levers with both arms while activating the yoked-clutches at the right time with the …