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T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis.
Jayaraman T, Marks AR. Jayaraman T, et al. Among authors: marks ar. Mol Cell Biol. 1997 Jun;17(6):3005-12. doi: 10.1128/MCB.17.6.3005. Mol Cell Biol. 1997. PMID: 9154798 Free PMC article.
T lymphocytes which have been made deficient in IP3R1 lack detectable IP3-induced intracellular calcium release and exhibit defective signaling via the T-cell receptor (TCR) (T. Jayaraman, E. Ondriasova, K. Ondrias, D. Harnick, and A. R. Marks, Proc. Natl. Acad. Sci …
T lymphocytes which have been made deficient in IP3R1 lack detectable IP3-induced intracellular calcium release and exhibit defective signal …
Rapamycin resistance tied to defective regulation of p27Kip1.
Luo Y, Marx SO, Kiyokawa H, Koff A, Massagué J, Marks AR. Luo Y, et al. Among authors: marks ar. Mol Cell Biol. 1996 Dec;16(12):6744-51. doi: 10.1128/MCB.16.12.6744. Mol Cell Biol. 1996. PMID: 8943329 Free PMC article.
Rapamycin inhibits vascular smooth muscle cell migration.
Poon M, Marx SO, Gallo R, Badimon JJ, Taubman MB, Marks AR. Poon M, et al. Among authors: marks ar. J Clin Invest. 1996 Nov 15;98(10):2277-83. doi: 10.1172/JCI119038. J Clin Invest. 1996. PMID: 8941644 Free PMC article.
Previously, we reported that the macrolide antibiotic rapamycin, but not the related compound FK506, inhibits both human and rat aortic SMC proliferation in vitro by inhibiting cell cycle-dependent kinases and delaying phosphorylation of retinoblastoma protein (Marx, S.O., T. Jay …
Previously, we reported that the macrolide antibiotic rapamycin, but not the related compound FK506, inhibits both human and rat aortic SMC …
887 results