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A novel combination therapy targets sonic hedgehog signaling by the dual inhibition of HMG-CoA reductase and HSP90 in rats with non-alcoholic steatohepatitis.
Mohammed OA, Youssef ME, Doghish AS, Hamad RS, Abdel-Reheim MA, Alghamdi M, Alamri MMS, Alfaifi J, Adam MIE, Alharthi MH, Alhalafi AH, Bahashwan E, Rezigalla AA, BinAfif DF, Abdel-Ghany S, Attia MA, Elmorsy EA, Al-Noshokaty TM, Fikry H, Saleh LA, Saber S. Mohammed OA, et al. Among authors: youssef me. Eur J Pharm Sci. 2024 Jul 1;198:106792. doi: 10.1016/j.ejps.2024.106792. Epub 2024 May 5. Eur J Pharm Sci. 2024. PMID: 38714237 Free article.
Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives.
Mohammed OA, Saber S, Abdel-Reheim MA, Alamri MMS, Alfaifi J, Adam MIE, Alharthi MH, Eleragi AMS, Eltahir HB, Abdalla MO, Bahashwan E, Ibrahim EK, Rezigalla AA, Abdel-Ghany S, Alzokaky AA, Doghish AS, El-Husseiny HM, Alghamdi M, Youssef ME. Mohammed OA, et al. Among authors: youssef me. Toxicol Appl Pharmacol. 2024 May;486:116943. doi: 10.1016/j.taap.2024.116943. Epub 2024 Apr 26. Toxicol Appl Pharmacol. 2024. PMID: 38677600
Orexins in apoptosis: a dual regulatory role.
Cavalu S, Saber S, Hamad RS, Abdel-Reheim MA, Elmorsy EA, Youssef ME. Cavalu S, et al. Among authors: youssef me. Front Cell Neurosci. 2024 Apr 12;18:1336145. doi: 10.3389/fncel.2024.1336145. eCollection 2024. Front Cell Neurosci. 2024. PMID: 38699177 Free PMC article. Review.
Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs: Evolutionary perspective in managing pulmonary fibrosis.
El-Kashef DH, Youssef ME, Nasr M, Alrouji M, Alhajlah S, AlOmeir O, El Adle Khalaf N, Ghaffar DMA, Jamil L, Abdel-Nasser ZM, Ibrahim S, Abdeldaiem MSI, Donia SS, Mohammed OA, Morsy NE, Shata A, Saber S. El-Kashef DH, et al. Among authors: youssef me. Biomed Pharmacother. 2022 Sep;153:113487. doi: 10.1016/j.biopha.2022.113487. Epub 2022 Jul 31. Biomed Pharmacother. 2022. PMID: 36076505 Free article.
Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling.
Saber S, El-Fattah EEA, Abdelhamid AM, Mourad AAE, Hamouda MAM, Elrabat A, Zakaria S, Haleem AA, Mohamed SZ, Elgharabawy RM, Morsy NE, El Adle Khalaf N, Mohammed OA, El-Bahouty WB, Mostafa SA, Abdelhady R, Galal O, ElSaid ZH, Yahya G, Shata A, Youssef ME. Saber S, et al. Among authors: youssef me. Biomed Pharmacother. 2023 Feb;158:114196. doi: 10.1016/j.biopha.2022.114196. Epub 2023 Jan 2. Biomed Pharmacother. 2023. PMID: 36916405 Free article.
Ambroxol, a mucolytic agent, boosts HO-1, suppresses NF-κB, and decreases the susceptibility of the inflamed rat colon to apoptosis: A new treatment option for treating ulcerative colitis.
Cavalu S, Sharaf H, Saber S, Youssef ME, Abdelhamid AM, Mourad AAE, Ibrahim S, Allam S, Elgharabawy RM, El-Ahwany E, Amin NA, Shata A, Eldegla M, Atef M, Aboraya M, Mohamed M, Anz N, Elmotelb DA, Gabr F, Elzablawy D, Hamada M, Yehia A, Osama D, Mohammed OA. Cavalu S, et al. Among authors: youssef me. FASEB J. 2022 Sep;36(9):e22496. doi: 10.1096/fj.202200749R. FASEB J. 2022. PMID: 35947115
Blunting p38 MAPKα and ERK1/2 activities by empagliflozin enhances the antifibrotic effect of metformin and augments its AMPK-induced NF-κB inactivation in mice intoxicated with carbon tetrachloride.
Abdelhamid AM, Youssef ME, Abd El-Fattah EE, Gobba NA, Gaafar AGA, Girgis S, Shata A, Hafez AM, El-Ahwany E, Amin NA, Shahien MA, Abd-Eldayem MA, Abou-Elrous M, Saber S. Abdelhamid AM, et al. Among authors: youssef me. Life Sci. 2021 Dec 1;286:120070. doi: 10.1016/j.lfs.2021.120070. Epub 2021 Oct 21. Life Sci. 2021. PMID: 34688695
Carbocisteine as a Modulator of Nrf2/HO-1 and NFκB Interplay in Rats: New Inspiration for the Revival of an Old Drug for Treating Ulcerative Colitis.
Abdelhamid AM, Youssef ME, Cavalu S, Mostafa-Hedeab G, Youssef A, Elazab ST, Ibrahim S, Allam S, Elgharabawy RM, El-Ahwany E, Amin NA, Shata A, Mohammed OA, Ibrahim Abdeldaiem MS, Alhowail A, El-Saber Batiha G, El-Mahmoudy EA, Attia M, Allam A, Zaater MY, Osman MM, Nader M, Taha A, Makarem NA, Saber S. Abdelhamid AM, et al. Among authors: youssef a, youssef me. Front Pharmacol. 2022 Jun 8;13:887233. doi: 10.3389/fphar.2022.887233. eCollection 2022. Front Pharmacol. 2022. PMID: 35754464 Free PMC article.
49 results