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Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity.
Futran AS, Lu T, Amberg-Johnson K, Xu J, Yang X, He S, Boyce S, Bell JA, Pelletier R, Suzuki T, Huang X, Qian H, Fang L, Xing L, Xu Z, Kurtz SE, Tyner JW, Tang W, Guo T, Akinsanya K, Madge D, Jensen KK. Futran AS, et al. Among authors: madge d. iScience. 2024 Apr 9;27(5):109693. doi: 10.1016/j.isci.2024.109693. eCollection 2024 May 17. iScience. 2024. PMID: 38689642 Free PMC article.
Deep learning enables rapid identification of potent DDR1 kinase inhibitors.
Zhavoronkov A, Ivanenkov YA, Aliper A, Veselov MS, Aladinskiy VA, Aladinskaya AV, Terentiev VA, Polykovskiy DA, Kuznetsov MD, Asadulaev A, Volkov Y, Zholus A, Shayakhmetov RR, Zhebrak A, Minaeva LI, Zagribelnyy BA, Lee LH, Soll R, Madge D, Xing L, Guo T, Aspuru-Guzik A. Zhavoronkov A, et al. Among authors: madge d. Nat Biotechnol. 2019 Sep;37(9):1038-1040. doi: 10.1038/s41587-019-0224-x. Epub 2019 Sep 2. Nat Biotechnol. 2019. PMID: 31477924
Action of clathrodin and analogues on voltage-gated sodium channels.
Peigneur S, Zula A, Zidar N, Chan-Porter F, Kirby R, Madge D, Ilaš J, Kikelj D, Tytgat J. Peigneur S, et al. Among authors: madge d. Mar Drugs. 2014 Apr 4;12(4):2132-43. doi: 10.3390/md12042132. Mar Drugs. 2014. PMID: 24714127 Free PMC article.
Tetrahydro-naphthols as orally available TRPV1 inhibitors.
Urbahns K, Yura T, Gupta JB, Tajimi M, Fujishima H, Masuda T, Yamamoto N, Ikegami Y, Marumo M, Yasoshima K, Yoshida N, Moriwaki T, Madge D, Chan F, Mogi M. Urbahns K, et al. Among authors: madge d. Bioorg Med Chem Lett. 2012 May 15;22(10):3408-11. doi: 10.1016/j.bmcl.2012.03.108. Epub 2012 Apr 6. Bioorg Med Chem Lett. 2012. PMID: 22525313
New pharmacological approaches to atrial fibrillation.
Milnes JT, Madge DJ, Ford JW. Milnes JT, et al. Among authors: madge dj. Drug Discov Today. 2012 Jul;17(13-14):654-9. doi: 10.1016/j.drudis.2012.02.007. Epub 2012 Feb 20. Drug Discov Today. 2012. PMID: 22370250 Review.
51 results