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Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity.
Jiang S, Yuan T, Rosenberger FA, Mourier A, Dragano NRV, Kremer LS, Rubalcava-Gracia D, Hansen FM, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis MH, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath JR, Krook A, Giavalisco P, Mann M, Larsson NG. Jiang S, et al. Among authors: rubalcava gracia d. Nat Metab. 2024 Apr 30. doi: 10.1038/s42255-024-01038-3. Online ahead of print. Nat Metab. 2024. PMID: 38689023
The constraints of allotopic expression.
Nieto-Panqueva F, Rubalcava-Gracia D, Hamel PP, González-Halphen D. Nieto-Panqueva F, et al. Among authors: rubalcava gracia d. Mitochondrion. 2023 Nov;73:30-50. doi: 10.1016/j.mito.2023.09.004. Epub 2023 Sep 20. Mitochondrion. 2023. PMID: 37739243 Review.
A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.
Kremer LS, Bozhilova LV, Rubalcava-Gracia D, Filograna R, Upadhyay M, Koolmeister C, Chinnery PF, Larsson NG. Kremer LS, et al. Among authors: rubalcava gracia d. PLoS Genet. 2023 Jan 6;19(1):e1010573. doi: 10.1371/journal.pgen.1010573. eCollection 2023 Jan. PLoS Genet. 2023. PMID: 36608143 Free PMC article.