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Functional and structural insights into activation of TRPV2 by weak acids.
Haug FM, Pumroy RA, Sridhar A, Pantke S, Dimek F, Fricke TC, Hage A, Herzog C, Echtermeyer FG, de la Roche J, Koh A, Kotecha A, Howard RJ, Lindahl E, Moiseenkova-Bell V, Leffler A. Haug FM, et al. Among authors: pumroy ra. EMBO J. 2024 Jun;43(11):2264-2290. doi: 10.1038/s44318-024-00106-4. Epub 2024 Apr 26. EMBO J. 2024. PMID: 38671253 Free PMC article.
Molecular details of ruthenium red pore block in TRPV channels.
Pumroy RA, De Jesús-Pérez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V. Pumroy RA, et al. EMBO Rep. 2024 Feb;25(2):506-523. doi: 10.1038/s44319-023-00050-0. Epub 2024 Jan 15. EMBO Rep. 2024. PMID: 38225355 Free PMC article.
Structural insights into TRPV2 activation by small molecules.
Pumroy RA, Protopopova AD, Fricke TC, Lange IU, Haug FM, Nguyen PT, Gallo PN, Sousa BB, Bernardes GJL, Yarov-Yarovoy V, Leffler A, Moiseenkova-Bell VY. Pumroy RA, et al. Nat Commun. 2022 Apr 28;13(1):2334. doi: 10.1038/s41467-022-30083-3. Nat Commun. 2022. PMID: 35484159 Free PMC article.
Context-Specific Function of the Engineered Peptide Domain of PHP.B.
Martino RA, Fluck EC 3rd, Murphy J, Wang Q, Hoff H, Pumroy RA, Lee CY, Sims JJ, Roy S, Moiseenkova-Bell VY, Wilson JM. Martino RA, et al. Among authors: pumroy ra. J Virol. 2021 Sep 27;95(20):e0116421. doi: 10.1128/JVI.01164-21. Epub 2021 Aug 4. J Virol. 2021. PMID: 34346767 Free PMC article.
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
Conde J, Pumroy RA, Baker C, Rodrigues T, Guerreiro A, Sousa BB, Marques MC, de Almeida BP, Lee S, Leites EP, Picard D, Samanta A, Vaz SH, Sieglitz F, Langini M, Remke M, Roque R, Weiss T, Weller M, Liu Y, Han S, Corzana F, Morais VA, Faria CC, Carvalho T, Filippakopoulos P, Snijder B, Barbosa-Morais NL, Moiseenkova-Bell VY, Bernardes GJL. Conde J, et al. Among authors: pumroy ra. ACS Cent Sci. 2021 May 26;7(5):868-881. doi: 10.1021/acscentsci.1c00070. Epub 2021 Apr 14. ACS Cent Sci. 2021. PMID: 34079902 Free PMC article.
23 results