Organic Cation Transporters are Involved in Fluoxetine Transport Across the Blood-Brain Barrier In Vivo and In Vitro.
Wang M, Sun Y, Hu B, He Z, Chen S, Qi D, An H, Wei Y.
Wang M, et al. Among authors: an h.
Curr Drug Deliv. 2022;19(4):508-517. doi: 10.2174/1567201818666210708122326.
Curr Drug Deliv. 2022.
PMID: 34238184
Fluoxetine concentration was determined by a validated UPLC-MS/MS method. RESULTS: The results showed that amantadine (an OCT1/2 inhibitor) and prazosin (an OCT1/3 inhibitor) significantly decreased the cellular accumulation of fluoxetine (P <.001). ...Furthermor …
Fluoxetine concentration was determined by a validated UPLC-MS/MS method. RESULTS: The results showed that amantadine (an OCT1/2 inhi …