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Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization.
Champiré A, Berabez R, Braka A, Cosson A, Corret J, Girardin C, Serrano A, Aci-Sèche S, Bonnet P, Josselin B, Brindeau P, Ruchaud S, Leguevel R, Chatterjee D, Mathea S, Knapp S, Brion R, Verrecchia F, Vallée B, Plé K, Bénédetti H, Routier S. Champiré A, et al. Among authors: mathea s. Eur J Med Chem. 2024 May 5;271:116391. doi: 10.1016/j.ejmech.2024.116391. Epub 2024 Apr 9. Eur J Med Chem. 2024. PMID: 38669909 Free article.
Structure of LRRK1 and mechanisms of autoinhibition and activation.
Reimer JM, Dickey AM, Lin YX, Abrisch RG, Mathea S, Chatterjee D, Fay EJ, Knapp S, Daugherty MD, Reck-Peterson SL, Leschziner AE. Reimer JM, et al. Among authors: mathea s. Nat Struct Mol Biol. 2023 Nov;30(11):1735-1745. doi: 10.1038/s41594-023-01109-1. Epub 2023 Oct 19. Nat Struct Mol Biol. 2023. PMID: 37857821 Free PMC article.
Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA.
Fathalla RK, Fröhner W, Bader CD, Fischer PD, Dahlem C, Chatterjee D, Mathea S, Kiemer AK, Arthanari H, Müller R, Abdel-Halim M, Ducho C, Engel M. Fathalla RK, et al. Among authors: mathea s. J Med Chem. 2022 Nov 10;65(21):14740-14763. doi: 10.1021/acs.jmedchem.2c01275. Epub 2022 Oct 21. J Med Chem. 2022. PMID: 36269107 Free PMC article.
A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.
Schwalm MP, Berger LM, Meuter MN, Vasta JD, Corona CR, Röhm S, Berger BT, Farges F, Beinert SM, Preuss F, Morasch V, Rogov VV, Mathea S, Saxena K, Robers MB, Müller S, Knapp S. Schwalm MP, et al. Among authors: mathea s. Front Cell Dev Biol. 2022 May 26;10:886537. doi: 10.3389/fcell.2022.886537. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35721509 Free PMC article.
Enabling pseudokinases as potential drug targets.
Preuss F, Chatterjee D, Dederer V, Knapp S, Mathea S. Preuss F, et al. Among authors: mathea s. Methods Enzymol. 2022;667:663-683. doi: 10.1016/bs.mie.2022.03.050. Epub 2022 Apr 13. Methods Enzymol. 2022. PMID: 35525558
39 results