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Page 1
Minimizing higher-order aggregation maximizes iron mobilization by small molecules.
Blake AD, Chao J, SantaMaria AM, Ekaputri S, Green KJ, Brown ST, Rakowski CK, Choi EK, Aring L, Chen PJ, Snead NM, Matje DM, Geng T, Octaviani A, Bailey K, Hollenbach SJ, Fan TM, Seo YA, Burke MD. Blake AD, et al. Among authors: burke md. Nat Chem Biol. 2024 Apr 25. doi: 10.1038/s41589-024-01596-3. Online ahead of print. Nat Chem Biol. 2024. PMID: 38664586
Amphotericin forms an extramembranous and fungicidal sterol sponge.
Anderson TM, Clay MC, Cioffi AG, Diaz KA, Hisao GS, Tuttle MD, Nieuwkoop AJ, Comellas G, Maryum N, Wang S, Uno BE, Wildeman EL, Gonen T, Rienstra CM, Burke MD. Anderson TM, et al. Among authors: burke md. Nat Chem Biol. 2014 May;10(5):400-6. doi: 10.1038/nchembio.1496. Epub 2014 Mar 30. Nat Chem Biol. 2014. PMID: 24681535 Free PMC article.
Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals.
Grillo AS, SantaMaria AM, Kafina MD, Cioffi AG, Huston NC, Han M, Seo YA, Yien YY, Nardone C, Menon AV, Fan J, Svoboda DC, Anderson JB, Hong JD, Nicolau BG, Subedi K, Gewirth AA, Wessling-Resnick M, Kim J, Paw BH, Burke MD. Grillo AS, et al. Among authors: burke md. Science. 2017 May 12;356(6338):608-616. doi: 10.1126/science.aah3862. Science. 2017. PMID: 28495746 Free PMC article.
A Mild Method for Making MIDA Boronates.
Kelly AM, Chen PJ, Klubnick J, Blair DJ, Burke MD. Kelly AM, et al. Among authors: burke md. Org Lett. 2020 Dec 18;22(24):9408-9414. doi: 10.1021/acs.orglett.0c02449. Epub 2020 Aug 25. Org Lett. 2020. PMID: 32841037
Fungicidal amphotericin B sponges are assemblies of staggered asymmetric homodimers encasing large void volumes.
Lewandowska A, Soutar CP, Greenwood AI, Nimerovsky E, De Lio AM, Holler JT, Hisao GS, Khandelwal A, Zhang J, SantaMaria AM, Schwieters CD, Pogorelov TV, Burke MD, Rienstra CM. Lewandowska A, et al. Among authors: burke md. Nat Struct Mol Biol. 2021 Dec;28(12):972-981. doi: 10.1038/s41594-021-00685-4. Epub 2021 Dec 9. Nat Struct Mol Biol. 2021. PMID: 34887566 Free PMC article.
Mitigation of SARS-CoV-2 transmission at a large public university.
Ranoa DRE, Holland RL, Alnaji FG, Green KJ, Wang L, Fredrickson RL, Wang T, Wong GN, Uelmen J, Maslov S, Weiner ZJ, Tkachenko AV, Zhang H, Liu Z, Ibrahim A, Patel SJ, Paul JM, Vance NP, Gulick JG, Satheesan SP, Galvan IJ, Miller A, Grohens J, Nelson TJ, Stevens MP, Hennessy PM, Parker RC Jr, Santos E, Brackett C, Steinman JD, Fenner MR Jr, Dohrer K, DeLorenzo M, Wilhelm-Barr L, Brauer BR, Best-Popescu C, Durack G, Wetter N, Kranz DM, Breitbarth J, Simpson C, Pryde JA, Kaler RN, Harris C, Vance AC, Silotto JL, Johnson M, Valera EA, Anton PK, Mwilambwe L, Bryan SP, Stone DS, Young DB, Ward WE, Lantz J, Vozenilek JA, Bashir R, Moore JS, Garg M, Cooper JC, Snyder G, Lore MH, Yocum DL, Cohen NJ, Novakofski JE, Loots MJ, Ballard RL, Band M, Banks KM, Barnes JD, Bentea I, Black J, Busch J, Conte A, Conte M, Curry M, Eardley J, Edwards A, Eggett T, Fleurimont J, Foster D, Fouke BW, Gallagher N, Gastala N, Genung SA, Glueck D, Gray B, Greta A, Healy RM, Hetrick A, Holterman AA, Ismail N, Jasenof I, Kelly P, Kielbasa A, Kiesel T, Kindle LM, Lipking RL, Manabe YC, Mayes J, McGuffin R, McHenry KG, Mirza A, Moseley J, Mostafa HH, Mumford M, Munoz K, Murray AD, Nolan M, Parikh NA, Pekosz A, Pfl… See abstract for full author list ➔ Ranoa DRE, et al. Among authors: burke md. Nat Commun. 2022 Jun 9;13(1):3207. doi: 10.1038/s41467-022-30833-3. Nat Commun. 2022. PMID: 35680861 Free PMC article.
A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages.
Ekaputri S, Choi EK, Sabelli M, Aring L, Green KJ, Chang J, Bao K, Choi HS, Iwase S, Kim J, Corradini E, Pietrangelo A, Burke MD, Seo YA. Ekaputri S, et al. Among authors: burke md. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2121400119. doi: 10.1073/pnas.2121400119. Epub 2022 Jun 22. Proc Natl Acad Sci U S A. 2022. PMID: 35737834 Free PMC article.
Preparation of MIDA Anhydride and Reaction with Boronic Acids.
Chen PJ, Kelly AM, Blair DJ, Burke MD. Chen PJ, et al. Among authors: burke md. Organic Synth. 2022;99:92-112. doi: 10.15227/orgsyn.099.0092. Epub 2022 May 25. Organic Synth. 2022. PMID: 37587918 Free PMC article.
Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal.
Maji A, Soutar CP, Zhang J, Lewandowska A, Uno BE, Yan S, Shelke Y, Murhade G, Nimerovsky E, Borcik CG, Arango AS, Lange JD, Marin-Toledo JP, Lyu Y, Bailey KL, Roady PJ, Holler JT, Khandelwal A, SantaMaria AM, Sanchez H, Juvvadi PR, Johns G, Hageman MJ, Krise J, Gebremariam T, Youssef EG, Bartizal K, Marr KA, Steinbach WJ, Ibrahim AS, Patterson TF, Wiederhold NP, Andes DR, Pogorelov TV, Schwieters CD, Fan TM, Rienstra CM, Burke MD. Maji A, et al. Among authors: burke md. Nature. 2023 Nov;623(7989):1079-1085. doi: 10.1038/s41586-023-06710-4. Epub 2023 Nov 8. Nature. 2023. PMID: 37938782 Free PMC article.
Nontoxic antimicrobials that evade drug resistance.
Davis SA, Vincent BM, Endo MM, Whitesell L, Marchillo K, Andes DR, Lindquist S, Burke MD. Davis SA, et al. Among authors: burke md. Nat Chem Biol. 2015 Jul;11(7):481-7. doi: 10.1038/nchembio.1821. Epub 2015 Jun 1. Nat Chem Biol. 2015. PMID: 26030729 Free PMC article.
281 results