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Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene.
Honma S, Kimishima A, Kimishima A, Honsho M, Kojima H, Tokiwa T, Nishitomi A, Kato S, Kondo N, Araki Y, Takahashi T, Chinen T, Usui T, Fuji SI, Ito K, Asami Y. Honma S, et al. Among authors: asami y. Biosci Biotechnol Biochem. 2024 Apr 25:zbae050. doi: 10.1093/bbb/zbae050. Online ahead of print. Biosci Biotechnol Biochem. 2024. PMID: 38664007
A Combination Strategy of Multidrug-Sensitive Budding Yeast and Chemical Modifications Enabling to Find a New Overlooked Antifungal Compound, Sakurafusariene, from In-House Fractionated Library.
Kimishima A, Ono Y, Sakai K, Sakai K, Honsho M, Naher K, Tokiwa T, Kojima H, Higo M, Nonaka K, Iwatsuki M, Fuji SI, Chinen T, Usui T, Asami Y. Kimishima A, et al. Among authors: asami y. J Agric Food Chem. 2023 Feb 14. doi: 10.1021/acs.jafc.2c09015. Online ahead of print. J Agric Food Chem. 2023. PMID: 36786603
Total Synthesis of Fusaramin, Enabling Stereochemical Elucidation, Structure-Activity Relationship, and Uncovering the Hidden Antimicrobial Activity against Plant Pathogenic Fungi.
Kimishima A, Hagimoto D, Honsho M, Sakai K, Honma S, Fuji SI, Iwatsuki M, Tokiwa T, Nonaka K, Chinen T, Usui T, Asami Y. Kimishima A, et al. Among authors: asami y. Org Lett. 2024 Jan 26;26(3):597-601. doi: 10.1021/acs.orglett.3c03792. Epub 2024 Jan 10. Org Lett. 2024. PMID: 38198624
Binding Mode-Based Physicochemical Screening Method Using d-Ala-d-Ala Silica Gel and Chemical Modification Approach to Facilitate Discovery of New Macrolactams, Banglactams A and B, from Nonomuraea bangladeshensis K18-0086.
Kimishima A, Suzuki Y, Kosaka S, Honsho M, Honma S, Tsutsumi H, Inahashi Y, Watanabe Y, Nakashima T, Asami Y, Iwatsuki M. Kimishima A, et al. Among authors: asami y. ACS Omega. 2024 Apr 5;9(15):17415-17422. doi: 10.1021/acsomega.4c00145. eCollection 2024 Apr 16. ACS Omega. 2024. PMID: 38645345 Free PMC article.
Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae.
Sakai K, Unten Y, Iwatsuki M, Matsuo H, Fukasawa W, Hirose T, Chinen T, Nonaka K, Nakashima T, Sunazuka T, Usui T, Murai M, Miyoshi H, Asami Y, Ōmura S, Shiomi K. Sakai K, et al. Among authors: asami y. J Antibiot (Tokyo). 2019 Sep;72(9):645-652. doi: 10.1038/s41429-019-0197-5. Epub 2019 Jun 17. J Antibiot (Tokyo). 2019. PMID: 31204387
300 results