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Extending the Potency and Lifespan of Antibiotics: Inhibitors of Gram-Negative Bacterial Efflux Pumps.
ACS Infect Dis. 2024 May 10;10(5):1458-1482. doi: 10.1021/acsinfecdis.4c00091. Epub 2024 Apr 25.
ACS Infect Dis. 2024.
PMID: 38661541
Free PMC article.
Review.
High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniae.
Blasco B, Jang S, Terauchi H, Kobayashi N, Suzuki S, Akao Y, Ochida A, Morishita N, Takagi T, Nagamiya H, Suzuki Y, Watanabe T, Lee H, Lee S, Shum D, Cho A, Koh D, Park S, Lee H, Kim K, Ropponen HK, Augusto da Costa RM, Dunn S, Ghosh S, Sjö P, Piddock LJV.
Blasco B, et al. Among authors: ropponen hk.
EBioMedicine. 2024 Apr;102:105073. doi: 10.1016/j.ebiom.2024.105073. Epub 2024 Mar 22.
EBioMedicine. 2024.
PMID: 38520916
Free PMC article.
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Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors.
Ropponen HK, Diamanti E, Johannsen S, Illarionov B, Hamid R, Jaki M, Sass P, Fischer M, Haupenthal J, Hirsch AKH.
Ropponen HK, et al.
ChemMedChem. 2023 Oct 4;18(19):e202300346. doi: 10.1002/cmdc.202300346. Epub 2023 Sep 28.
ChemMedChem. 2023.
PMID: 37718320
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Assessment of the rules related to gaining activity against Gram-negative bacteria.
Ropponen HK, Diamanti E, Siemens A, Illarionov B, Haupenthal J, Fischer M, Rottmann M, Witschel M, Hirsch AKH.
Ropponen HK, et al.
RSC Med Chem. 2021 Mar 3;12(4):593-601. doi: 10.1039/d0md00409j. eCollection 2021 Apr 28.
RSC Med Chem. 2021.
PMID: 34046630
Free PMC article.
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Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity.
Ropponen HK, Bader CD, Diamanti E, Illarionov B, Rottmann M, Fischer M, Witschel M, Müller R, Hirsch AKH.
Ropponen HK, et al.
ChemMedChem. 2021 Jul 6;16(13):2089-2093. doi: 10.1002/cmdc.202100067. Epub 2021 May 7.
ChemMedChem. 2021.
PMID: 33844432
Free PMC article.
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Mastering the Gram-negative bacterial barrier - Chemical approaches to increase bacterial bioavailability of antibiotics.
Ropponen HK, Richter R, Hirsch AKH, Lehr CM.
Ropponen HK, et al.
Adv Drug Deliv Rev. 2021 May;172:339-360. doi: 10.1016/j.addr.2021.02.014. Epub 2021 Mar 8.
Adv Drug Deliv Rev. 2021.
PMID: 33705882
Review.
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