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Machine learning methods for predicting guide RNA effects in CRISPR epigenome editing experiments.
bioRxiv [Preprint]. 2024 Apr 19:2024.04.18.590188. doi: 10.1101/2024.04.18.590188.
bioRxiv. 2024.
PMID: 38659894
Free PMC article.
Preprint.
Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens.
Black JB, McCutcheon SR, Dube S, Barrera A, Klann TS, Rice GA, Adkar SS, Soderling SH, Reddy TE, Gersbach CA.
Black JB, et al. Among authors: klann ts.
Cell Rep. 2020 Dec 1;33(9):108460. doi: 10.1016/j.celrep.2020.108460.
Cell Rep. 2020.
PMID: 33264623
Free PMC article.
Item in Clipboard
Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.
Huang J, Chen M, Xu ES, Luo L, Ma Y, Huang W, Floyd W, Klann TS, Kim SY, Gersbach CA, Cardona DM, Kirsch DG.
Huang J, et al. Among authors: klann ts.
Sci Rep. 2019 Nov 20;9(1):17220. doi: 10.1038/s41598-019-53572-w.
Sci Rep. 2019.
PMID: 31748650
Free PMC article.
Item in Clipboard
Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells.
Pickar-Oliver A, Black JB, Lewis MM, Mutchnick KJ, Klann TS, Gilcrest KA, Sitton MJ, Nelson CE, Barrera A, Bartelt LC, Reddy TE, Beisel CL, Barrangou R, Gersbach CA.
Pickar-Oliver A, et al. Among authors: klann ts.
Nat Biotechnol. 2019 Dec;37(12):1493-1501. doi: 10.1038/s41587-019-0235-7. Epub 2019 Sep 23.
Nat Biotechnol. 2019.
PMID: 31548729
Free PMC article.
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Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing.
Klann TS, Crawford GE, Reddy TE, Gersbach CA.
Klann TS, et al.
Methods Mol Biol. 2018;1767:447-480. doi: 10.1007/978-1-4939-7774-1_25.
Methods Mol Biol. 2018.
PMID: 29524151
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CRISPR-based methods for high-throughput annotation of regulatory DNA.
Klann TS, Black JB, Gersbach CA.
Klann TS, et al.
Curr Opin Biotechnol. 2018 Aug;52:32-41. doi: 10.1016/j.copbio.2018.02.004. Epub 2018 Feb 28.
Curr Opin Biotechnol. 2018.
PMID: 29500989
Free PMC article.
Review.
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CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.
Klann TS, Black JB, Chellappan M, Safi A, Song L, Hilton IB, Crawford GE, Reddy TE, Gersbach CA.
Klann TS, et al.
Nat Biotechnol. 2017 Jun;35(6):561-568. doi: 10.1038/nbt.3853. Epub 2017 Apr 3.
Nat Biotechnol. 2017.
PMID: 28369033
Free PMC article.
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